PGTA testing, no abnormalities and failed to implant?

[Whooper]

Hi IVF warriors,

Failed on two IVF rounds, had one fresh transfer last year also used one last frozen embryo this January and failed to implant...

So planning to start again from scratch, i mean egg collection and then to do PGTA testing on embryos to see if there are any abnormalities... Has anyone done this testing and had a normal embryo transfer which still failed to implant? Just wondering if it's really worth going this path as this is very expensive testing...

Thank you for your answers 🙏

[skygreen]

Hi Whooper,

Hope you are doing ok 🤗

I did PGTA in 2019 during 2nd cycle of IVF, age 36, 5 day 5 blasts tested and 2 were euploid. One of those is now my gorgeous 4 year old and we did a FET in 2021 with the second embryo but that failed to implant. No reason why.

I'm glad I did it as it saved me the heartache of transferring embryos that would have failed.

I did 2 banking cycles last year and we got 5 D5 blasts and again only 2 were euploid. Just did a FET last week and now in 2ww but feel ok as I know a good quality embryo is on board.

Financially for me it probably works out the same as doing 2 FETs with untested embryos but with a much better piece of mind.

What has your clinic advised?

X

[Mudra85]

Sadly it's not uncommon for PGT-A normal embryos to fail. PGT-A only tests to see if an embryo has the correct number of chromosomes, so other genetic abnormalities which could cause them to fail are not picked up with PGT-A testing.However, what PGT-A does do is enable the transfer of only the embryos that will have a chance of leading to a live birth (completely chromosomally abnormal embryos will not have a chance). This can save time and if you do get pregnant reduce the chance of having a miscarriage.

Not sure if any of that helps, but I wish you the very best of luck with deciding on your next steps.

[Millbanks in reply to Mudra85]

Exactly what she said!!

[Natasha2012]

hi ❤️ no advice but just want you to know I’m going through exactly the same . Two failed transfers in 3 months ( untested also ) one left but lost confidence now . feeling quite overwhelmed . Feel free to pm me if you want to chat xxx

[Whooper in reply to Natasha2012]

Hi Natasha,

Always feels like lost all our hopes, but each failure makes us stronger… the only thing freaks me out, because I’m going to be 40 this summer… means things aren’t going to get any easier with age… not going to rush into transfers, first going to do all the testings and then go from there.

[Natasha2012 in reply to Whooper]

It does make us stronger ! I have my review consultant on Tuesday . I have so much to ask , hopefully I get the feedback I need . I feel like I’m having to investigate possible issues myself at the moment and feeling quite lonely in a sense with it all . When do you think you will start egg collection ? Il be with you on that ❤️ xxxx

[Whooper in reply to Natasha2012]

You are very lucky that you have an appointment on Tuesday, I have to wait for consultation till 7th of march… so while I am waiting, trying to get a referral for HSG. Want to make sure there are no issues with my tubes. Checked last year in August, everything was fine, had a small polyp removed.

You can always contact me whenever you are feeling lonely. 😉

[Natasha2012 in reply to Whooper]

What test did you have to show the polyp? I have only had the baseline scan which shows fluid in my c section scar and fluid by one ovary , they said it was fine but now I’m reading up on things that is not really the case so I feel really upset to be honest with my clinic . I feel like I have wasted 10k when I should have been checked out properly prior to started ivf . X

[Whooper in reply to Natasha2012]

My clinic did the baseline scan before my fresh transfer and discovered a polyp, so then I had to book the hysteroscopy which was very painful and most unpleasant procedure.

Sorry to hear about fluids… I did hear something about fluid in a c section can affect embryo implantation. Is there anything you can do to get it removed?

[Natasha2012 in reply to Whooper]

I’m trying to get hold of Adrian lower who a few women have spoken about in terms of repairing the niche ❤️ xxxx

[Natasha2012 in reply to Whooper]

sorry to hear it was so horrible . I have got an appointment with Adrian lower next month who is an expert in uterine fibroids so I’m hopeful if there is anything it can be sorted ❤️ and yes it definitely can and I just trusted my clinic when they said it would affect anything xx

[Whooper in reply to Natasha2012]

Glad to hear that finally you got an appointment with the professional. Sometimes I am wondering that maybe I have something as well and doctors are not noticing… I am not having best luck with them so far, especially then it comes to my gp i can’t even get a simple appointment nowadays.

[Hanj10]

After multiple miscarriages I did ivf with pgta testing of the embryos (half were normal) and out of 4 transfers - 1st didn’t implant, 2nd is my little boy , 3rd didn’t implant and 4th is my current (10weeks) pregnancy. As said before the pgta just tests for correct chromosomes so other genetics that could impact success aren’t tested for. My main reasoning was to reduce the risk of miscarriage. Good luck xx

[Wishinandahopin]

PGTA normal embryos have a 50% live birth rate. So there are no guarantees and there can always be something else going on in the body. I had PGTA testing from the start. Our two ‘normal’ tested embryos failed to implant over two separate FETs. That said it was really useful knowing that the failed embryos were normal, as failing twice is very unusual for normal embryos. That led us to get more testing done on me and I found some immune issues. We managed to get support and meds for that and my next FET (with a mosaic tested embryo) worked! So PGTA is by no means a guarantee but it can give more information.

[Chel91]

Yes I've had a euploid embryo fail. Studies show that PGT-A testing generally only reduces chances, it doesn't increase them. PGT-A is slightly in-accurate also, only in the last few years they realized that mosaic, segmental abnormal, polyploid abnormal (and probably other) embryos could actually be normal. Leading to ladies throwing away potential embryos.

I think some studies show it begins to be more beneficial in ladies around 40 or above (due to higher abnormal rates), those with a history of recurrent MC who want to avoid as much trauma as possible, and maybe those with large amounts of embryos and / or RIF (which is why I did it) to get more info. Especially if you only have a small amount of embryos it may not financially be worth it (depending on all the costs). xx

[Babyhope8]

I had 1 euploid failed to implant, next implanted and miscarriages at 7w after seeing strong heartbeat and 3rd failed to implant again