We have been trying for a baby for 5 years. I have had two rounds of IVF and 7 transfers. One was successful but ended in miscarriage at 6 weeks. My embryos have all been high graded.
I have 1 embryo left in the freezer, can anyone recommend any advice or anything to increase my chances of this last one implanting?
hiya - so sorry to hear 💔 have you have your embryos tested? The only reason I ask is I had 2 failed transfers fail from high graded embryos, so pgta tested our remaining frozen embryos (5) and all were aneuploid. All graded between 5AA-5BC. Wishing you lots of luck with what’s next xx
Hi, I did ask for them to be tested but I am having my treatment with the NHS and they said if we tested every embryo they wouldn't transfer any.
hello, depending on where you’re based, have you considered the Tommy’s clinic at University Hospital Coventry & Warwick? I’m in London but self-referred here after my friend recommended - she had 10 losses before finding what she needed with this clinic’s help. All the best 💜
Thank you, I am based in Wales. Currently having treatment through the NHS
If you have the energy atm, Tommy’s might be great support 💜
Have you been tested for NK cells? If not maybe it might be worth having a look into. Good luck!
Hi, no I haven't. I am having treatment with the NHS and did ask them about it last year and they said because I had one successful implantation (it did end at 6 weeks) that they wouldn't look into anything further.
It tends to be private clinics that look into it, might be worth it? I know ARGC does testing
hi, I’m so sorry but even I’m on the same journey as yours.
We got NK cells tested at endometrial level. Turns out they are much higher than normal.
So I’m on immunosuppressants right now with Intralipid + IVIG protocol for the next transfer.
Hoping and praying hard this works 🙏🏼
All the very best. Please do look into the immunotherapy aspect of IVF.
Hi, no I haven't. I am having treatment with the NHS and did ask them about it last year and they said because I had one successful implantation (it did end at 6 weeks) that they wouldn't look into anything further. Would a private clinic do it?
I am also wishing you the best of luck! Please let me know if it works.
Hi, so sorry to hear... did your clinic suggest any test why apart from this 1 transfer which implanted others did not? After so many failed implanters it just screams to check up on what could be the cause. Whether the embryo is aneuploid or euploid is one thing but why others don't stick is another, my last 2 transfers both stick, one ended in mc at 7w and another was chemical and the clinic said that possible it could be something wrong with the embryos (I didn't pgta test) I already had investigation for recurrent mc and I am on the right meds and everything else looked perfect. Are you NHS self-funded? If yes maybe it's worth looking around for a private clinic and they will definitely investigate.
They said because I had one implantation they wouldn't test for anything else. I have an appointment in a few weeks I am going to ask again. The NHS are funding it. I am happy to save and pay for further tests if its not something they can offer. Sorry to hear about your miscarriages. Has it worked for you now?
I see, maybe it's worth asking a private clinic for an investigation before your next transfer with NHS, if NHS refuses to check. And if you can, ask on your NHS appointment (when they will refuse testing) if they could show you research or NHS guidance as their reason for not testing for the recurrent implantation failure, this 1 time could be the lucky shot but how they will explain the next several fails. After they will give you their answer ask them that you would like to have in writing that they are refusing to do an investigation for recurrent failed implantation for your last 6 transfers.
Thank you so much for your help. I will ask.
100% recommend some further testing - I did get some on the NHS and others privately which my NHS doctor reviewed. The NHS are limited in what they can do but I got thrombophillia, immune testing and then privately I got NK cells, biopsy which showed up some interesting results. I’ve had 6 transfers for context on the NhS.
Thank, you I will going to speak to the NHS doctor and also seek to have testing privately. Has it worked for you since? Were the NHS then able to treat you?
It hasn't worked for us yet - the NHS weren't able to get a transfer to work, but we're quite a complex case.
