failed cryo embryo transfer

[Flora_bah]

Hello

I am a 44yo woman. My husband and I underwent ivf cycle earlier this year with own egg.

We managed to get 9 eggs and 5 embryo. We had to get them genetically tested and after the long process we have 1 frozen embryo of high quality.

So we were very excited about the next step and we started the preparation for frozen embryo transfer. Unfortunately, I didn’t respond to the oestrogen. And Uterine lining was too thin so doctor didn’t want to go ahead.

We tried again with a much strong dose (6mg of oestrogen+ 2 estrodial patches + 2 estrodial gel. )

Again, it didn’t work. Now we don’t know what to do. Our doctor (clinic in Prague) seems dumbfounded - which is weird. And does not know what to advise.

I wonder if anyone has found themselves in this situation. Any advice ? Any doctor recommendation ?

Thank you in advance

[Chasing123]

I don’t have an answer for you but I had the same issue. I tried for quite a few months in a row and I did have a couple of times that it increased after circa 5 weeks of medication (instead of 2), but other times it didn’t and now it won’t at all. Perhaps they could try a longer time frame? Otherwise, unfortunately, I have to say we decided to move on to trying to find a surrogate. Sending you lots of luck on your journey.

[Flora_bah in reply to Chasing123]

Thank you 🙏

[Tarasunny]

How thin was your lining? I tried high dose vitamin e before my last transfer and it helped me, both my embryos stuck as well! I've heard l' arginine can work too but not on a fresh cycle as I think it can affect egg growth or quality or something. It's on the "it starts with the egg" website.

[Babytocome]

This didn’t t happen to me, but I was following a doctor from Harvard called the egg whisper, maybe you could find some valuable information. I also know there is a clinic in the south uk that has a doctor that does logos of research and take cases. Some ladies here has gone to him. Worth asking in the forum. Good luck!

[Flora_bah in reply to Babytocome]

Thank you! Lining was 4.7mm and 5mm at day 19.

If you have a name of specialist, please DM me

[DreamingOfTwo79]

Hello Flora, that's great news that you managed to get one PGT-A tested embryo! Have you considered a natural or modified natural cycle instead of the medicated protocol you appear to have been on? I am also 44 and currently 26 weeks pregnant. As I still had regular cycles and no issues like endometriosis or adenomyosis my consultant recommended to try a modified natural cycle where I took stimulation meds every other day from Day 3 to induce a "superovulation", I had about two follicles growing strong during the transfer month and ovulated one of them after taking a trigger shot which helped with the natural progesterone production. Some ladies on here in their forties even went with just their natural cycle and transferred five days after they had their ovulation confirmed via scans and bloods. It may be worth looking into this further as lots of ladies on here report better success with thicker linings following a natural or modified natural cycle transfer protocol. Wishing you the best of luck! x

[Flora_bah in reply to DreamingOfTwo79]

Thank you so much! Could you send me the name of your clinic or doctor ? I think we need a second opinion. Our doctor cannot recommend anything and I can’t really self medicate.

Thank you so so much !!

[LSandJ]

Hi, I used 12mg of progynova each day to thicken my lining (not 6. But also none of the other types you used). Often ladies go for a natural FET? If you're regular this should be pretty straight forward! Many clinics prefer not to as you need to scan frequently around ovulation and can miss it, which can mean waiting another month! But many ladies prefer it. You can do no drugs at all, or some will do progesterone support after ovulation.

(If you have a very varied cycle this can be hard. Have you used ovulation strips before and do you get a clear surge?)

[Flora_bah in reply to LSandJ]

Hi!

Thanks for your reply.

The issue for me that the endometrium is too thin (4.5mm) even at day 19 so the doctor says the implantation won’t work.

We have tried different protocols but I don’t seem to respond to the oestrogen. And a natural cycle is no better.

This is why I was hoping for help.

Thank you xx

[LSandJ in reply to Flora_bah]

Oh sorry! On a natural cycle your lining is too thin too? You've tried a natural but also had to cancel that???

[Flora_bah in reply to LSandJ]

Yes, sadly!

[Daisy-Delilah]

Hello, that’s great news about your embryo! Sorry to hear about your lining issues though 🙁

I have had similar issues and have had about 6/7 cycles cancelled because of thin lining and my body never responded to the oestrogen.

We were lucky that we had a number of embryos and so we took a chance on a 4.5 lining and we had a successful pregnancy and my little boy.

I have used the same protocol since and got up to a 6mm which is about the highest I’ve got to. We did gonal f on alternate days to stimulate the follicles and that meant my body naturally produced estrogen which thickened the lining, but it never gets as thick as they want. I’ve been advised to try an endometrial scratch which I’m not sure about yet.

Do you know what your lining was when you did the egg collection? X

[Flora_bah in reply to Daisy-Delilah]

Oh that’s interesting that you had a successful pregnancy with a thin lining! Congratulations on your little boy.

When we did the egg collection, the lining was very thin too (5mm I think).

can you explain what is “gonal F” ?

I am currently trying to find another physician to have another opinion on the protocol because my doctor does not know what to suggest.

Thank you !! Xx

[Daisy-Delilah in reply to Flora_bah]

Thank you! And sorry for the late reply.

Mine was always thin too- but my doctor also looked at the appearance and quality of that to see if it was trilaminar.

Gonal f is an injection used to stimulate the follicles- usually used for a fresh cycle.

Good luck finding a new consultant xxx

[Spicycurry]

Natural modified frozen transfer with mild stims every other day to increase lining. I also did oestrogen priming before starting stims due to high fsh. My lining got to 15mm and then 13mm on transfer day.