Beta at 7dp5dt

[NoHope1323]

So, today I'm 6dp5dt (this was my 11th transfer) and this morning I got the usual BFN.

I've decided to have a blood test tomorrow at 7dp and then quit meds, since beta will surely come out negative. I think that this way I won't risk anything, because if something is there (but it won't) at 7pt should be visibile in a blood test even if super low, am I right?

I just want to schedule my next transfer ASAP without clinging to false hopes. I know I'm not pregnant, all symptoms have subsided since 3dpt and every sensible home test is negative, there's no way it worked.

[DianeArnold Partner Nurse Fertility Network UK]

Hi NoHope. My feelings are that you should continue with your prescribed medications and test on the day recommended by your clinic, using the first urine of the day. Good luck. Diane

[NoHope1323 in reply to DianeArnold]

Hi, thanks for the reply.

They won’t allow me to quit meds at 7dp since OTD is 10dp, but I don’t want to delude myself. Negative beta at 7pt will stay negative later too.

[Tamaa]

Hi NoHope. I agree with Diane. I would strongly recommend waiting till Official test day.. I have read a few research papers and it was recommended testing beta hcg 10 days post embryo transfer. And Urine test 13 to 14 days post transfer. I personally don't see any risk in continuing medicines till OTD, not sure what you meant by it. All the best!

[NoHope1323 in reply to Tamaa]

Hi Tamaa, thanks for your reply.

The fact is that my clinic will be closed for holidays after the 8th August and I just want to do my last transfer before that. I know the last embryo left won't stick (untested BB blastocyst, almost 100% aneuploid giving my age) so I really want to move on and switch to egg donor ASAP.

I have had one ectopic and a couple of chemicals pregnancies before, and each one have given me faint positives by 6-7pt. I know that if tomorrow my beta will be zero, they will remain zero, chances are too low to be optimistic about it.

[Skittles11]

I would discuss your intentions with your clinic before you stop taking any medicines. Good luck x

[NoHope1323 in reply to Skittles11]

Hi, thanks for the reply.

There’s no way they allow me to quit meds at 7dp since OTD is 10dp, but I don’t want to delude myself. Negative beta at 7pt will stay negative later too.

[Esb27]

I wouldn't stop your meds, 7dp is still very early (it might not even come up on bloods this early). I am in a very similar boat to you, got a BFN at 7dp and today (9dp) but I'm waiting until test date on Weds (11dp) just to be sure. It's soo frustrating as you know in your heart it's over but there's a reason why the OTD is around 11dp. The only thing I'm clinging to is the stories of people who have had negatives on the days I've tested then on OTD it turns positive. Who knows, maybe we will be in the same boat?! I know you might think that is deluded but sometimes you have to just hope (even if it's only at 0.5%)

But I get it, it's f**king hard. You just want to put this cycle to bed and move onto the next one - I'm the same - but what is 3 days going to do? if it was a week or two difference I'd understand but really starting 3 days after you want to will be fine.

I'm sorry you're going through this again, it never gets easy each time does it.

[NoHope1323 in reply to Esb27]

Hi Esb, thanks for your reply.

The fact is that my clinic will be closed for holidays after the 8th August and I just want to do my last transfer before that. I know the last embryo left won't stick (untested BB blastocyst, almost 100% aneuploid giving my age) so I really want to move on and switch to egg donor ASAP.

I have had one ectopic and a couple of chemicals pregnancies before, and each one have given me faint positives by 6-7pt. I know that if tomorrow my beta will be zero, they will remain zero, chances are too low to be optimistic about it…

As you said, it’s very hard. I hope your outcome will be different from mine.

Hugs.

[Esb27 in reply to NoHope1323]

Ah right okay! Weird how it closes in August! I know kids go on summer break but medical places shouldn't ha.

I feel you, i've had ectopics and chemicals, it's hard. It's so hard to believe though but I feel like every pregnancy and 2ww seems to sometimes differ - some people say they get positives or negatives by 6/7dp, other's say it took them until 13dp to get any positive. You cling to this hope then when it doesn't happen to you it's so disappointing, even though you already know in your heart/body!!

Thank you! I hope your blood test goes okay and gives you peace of mind, and that you are able to do another transfer asap.

[NoHope1323 in reply to Esb27]

Thanks, I hope so.

Speaking of late positives (7-8-9 pt), I think it’s a very weird occurrence and pretty much an anomaly because it would be logical to expect a positive at 5-6pt, since implantation should start 1-2 days after transfer. I always wondered what the blastocyst do in your uterus for a whole week, just chilling while floating around? 😩 If you think about it that just doesn’t make sense but oh well, in the end no one knows what truly happens down there after the transfer.

Anyway, I suspect that those who have such late positives are using not very sensitive tests. With tests with a sensitivity of 10, it’s impossible not to see anything early.

[Esb27 in reply to NoHope1323]

Yeah it's weird isn't it. I sometimes wish we had a little window so we could see what was going on, as the not knowing and questioning every symptom is so frustrating!!

[Twiglet2]

I agree that I have never had a negative turn around after day 8 to a positive but my friends just had day a day 8 and 9 negative that did turn around at 12dp5dt amd are now 14 weeks so it can happen. It’s literally an extra 3 days of meds and after all the time and effort that goes into a cycle I personally would keep taking the meds on that very very slim chance. I doubt the clinic will start the ball rolling on next transfers etc anyway until at least your test day and we need to have a bleed in between (in case that’s the case for you too). Here’s what’s going on in there after a 5 day embryo transfer the embryo does have a bit of work to do to implant (especially if it’s a frozen one or can be a bit longer too)

Day 1: The blastocyst begins to hatch out of its shell.

Day 2: The blastocyst continues to hatch out of its shell and begins to attach itself to the uterus.

Day 3: The blastocyst attaches deeper into the uterine lining, beginning implantation.

Day 4: Implantation continues.

Day 5: Implantation is complete. Cells that eventually become the placenta and fetus have begun to develop.

Day 6: Human chorionic gonadotropin (hCG), the hormone that signals a developing pregnancy, starts to enter the blood stream.

Days 7 and 8: Fetal development continues and hCG continues to be secreted.

Day 9: Levels of hCG are now high enough in maternal blood to detect a pregnancy using a blood test.

[NoHope1323 in reply to Twiglet2]

Thanks for you reply.

Well, your friend is maybe one out of a hundred. I would never dream of being that lucky since that's not the norm, considering that often late implanters lead to a negative outcome. Anyway I'm 100% sure that today's beta will be zero, so it's ok. The sooner I can start with a new cycle, the better.

[Rhubarb5]

Don’t stop your meds. For one of my attempts I didn’t get a BFP until 12 dpt. It didn’t end well unfortunately but I really think 7dpt is too early. It’s horrible to continue the drugs when you feel so strongly that it hasn’t worked but just try and keep going for the extra 3 days.

[NoHope1323 in reply to Rhubarb5]

I'm sorry for your loss. I have had 3 miscarriages and I know that late implanters often lead to a negative outcome. For that reason I don't want to continue with the meds if today's beta will be zero (and I'm 100% sure they will be).

[mmc224 in reply to NoHope1323]

I don't know if it helps but of my 2 ivf transfers, I had a positive on a sensitive test from day 6/7 for the fresh transfer and no positive on the test until 12 dpo for the frozen transfer. The clinic said frozen can take an extra 2-4 days to show up on tests.

Both transfers successful, we were really really lucky. We were doing ivf because I lost both tubes and 1 ovary ectopics before that.

[NoHope1323 in reply to mmc224]

Thanks for your reply.

12 DPO is technically 6dp5dt, tho 🤔 So you had your positives in the same time frame for both your fresh and frozen transfer, I guess.

Anyway, beta was negative, so no problem.

[mmc224 in reply to NoHope1323]

Sorry to hear that. Good luck for the next one.

[NoHope1323 in reply to mmc224]

Thank you

[OurMiracleBabies]

After so many transfers I think I would deal with my grief in a similar way to you . I can hear your pain behind decision.

But I am curious to what you were hoping for when you posted ? As you sound very certain and resolved in your decision.

Best of luck on your continued journey. It sure ain't easy .

[NoHope1323 in reply to OurMiracleBabies]

Thanks for your reply.

I don't know, it's just a rant. I can't talk about IVF with anyone (except my husband) and this whole process is so unfair that sometimes I just need to vent.

Best luck to you too.

[OurMiracleBabies in reply to NoHope1323]

OK.. yes I understand totally. I get that .

[Jdsbaby]

I agree with you. I recently had a blood test done on 7dp5dt after all BFNs on FRERs and it came back 4. Obviously I did not stop meds as my doctor insisted it is still a positive for 7dp. However, my official beta on 10dp5dt was 1. And I stopped all meds that day. My point is that - I think you think about it reasonably in the case that hcg is trace positive on 7dp you could still continue meds even though such a late positive rarely works but if it is zero I think it is reasonable to assume that the cycle failed. Best of luck.

[NoHope1323 in reply to Jdsbaby]

Thanks for your reply. Beta was zero so I can quit meds without problems.

[NoHope1323]

UPDATE: Beta was zero, as expected. I already quit meds and I hope to be able to prepare for next transfer soon (this will be our last embryo, then we have to switch to donor eggs).

[OurMiracleBabies in reply to NoHope1323]

Sending you best wishes.

[NoHope1323 in reply to OurMiracleBabies]

Thank you

[Msze]

I wouldn’t quit meds ever. What’s another few days?

[NoHope1323 in reply to Msze]

Hi! Beta was zero as I thought, so it’s over.

[Msze]

I’m so sorry. Are you able to genetically test the embryos?

[NoHope1323 in reply to Msze]

Thanks.

Nope, because it is too expensive and it doesn’t give you any guarantee of success anyway. Even a perfect tested embryo could fail implantation

[Pipidugacarapa in reply to NoHope1323]

yes but it has better chance to implant and lead to successful pregnancy. My clinic has rate about 65-70% per transfer for pga/s tested embryo. They actually recommend testing for age over 35. Perfect rated embryo can be genetically bad and that perfect looking embryo wouldn’t implant it would lead to miscarriage (for example I had 5AA frozen on day 5 and turned out that was missing chromosome). So pg testing removes those kind of good looking but actually non viable embryos. But, they do recommend testing if there are 5 or more embryos frozen, if not I think it’s worth it to transfer and see. Our body tends to recognize bad embryos (hence no implantation or early miscarriages- I had two prior ivf). Anyhow, I agree with your post that if beta from blood is negative on 7dp5dt then it’s defnegative. I got faint lines on days 4-5-6, gradually increasing and on day 7-8 I had visible positives (on normal urine test, not early response). Good luck to for your next transfer and hopefully is one great embryo ready to be baby 🤞🏻🤞🏻🤞🏻🙏🏻

[NoHope1323 in reply to Pipidugacarapa]

It’s not a good embryo (BB graded like the last 4 that failed from the same ER) but thanks. At least, after this one, we can switch to donor egg and (maybe) have better chances.

[Pipidugacarapa in reply to NoHope1323]

BB is not bad embryo! I think there’s chance just be positive 🤞🏻🙏🏻

[NoHope1323 in reply to Pipidugacarapa]

Sadly I don’t think so because all the other embryos have failed to implant, so I can’t see why this time should be different. I mean, of course it would be great, but deep inside me I know it can’t work.