PTG test result-low level mosaicism and success rate

[Priyasharma]

I have history of multiple miscarriages , this was my 7th egg retrieval and now the age is over 37.My PGT test report confirm

2-low level mosaicism and rest aneuploid.

Please help if any one have had success with low level mosaicism.

[Tryingtostaycalm]

Following.

We also have 2 low mosaics, a history of implantation failure and miscarriage. We and are having a meeting with a Genetic Counsellor on Monday so hope to understand more as my consultant doesn’t seem keen to transfer the 2 low mosaic due to higher chance of miscarriage.

[Priyasharma in reply to Tryingtostaycalm]

My consultant has not reverted yet.. I m surprised and sad..why this

[JA-fnuk Partner Nurse Fertility Network UK]

Has your embryologist explained what a low-level mosaic embryo means? That might help put your mind at ease. Hope you get some replies from this forum as all the ladies very supportive towards each other

Take care

Janet

[Priyasharma in reply to JA-fnuk]

Will consult this Saturday

[Haf05]

We have two low mosaics, but haven't yet had them transferred, so cannot unfortunately give you a success story. We have had genetic counselling, however and, as i understand it, the risks attached to low mosaics, depend on: (i) the particular chromosomes affected, and (ii) the number.

I would suggest you discuss with a genetic counsellor.

[Priyasharma in reply to Haf05]

Yes.. will visit this Saturday

[Haf05 in reply to Priyasharma]

Don't lose hope. Based on the advice we received from our genetic counsellor, we will probably give one of the low mosaics ago . I did a fair amount of research, and there are lots of success stories with low mosaic embryos (there are even success stories with abnormal embryos - there are countries e.g. the US where you can have an abnormal embryo transferred).

[Priyasharma in reply to Haf05]

Thanks for assurance.. l will speak with my dr. I had history of 3 miscarriage in last 1years..all IVF so..let's see

[Jumpppy]

I've had success with low-level mosaic and abnormal. Key seems to be if it will implant; if so most likely the embryo is fine. I have twins from a low-level + abnormal transfer (amnio was all clear on both) and currently 7.5wk (confirmed HB) with low-level mosaic (will take some weeks before amnio to know outcome, but so far they are confident). The "genetic counselor" HIGHLY recommended I NOT transfer any of these. I received different advice from an RE that specializes in this area (embryo genetics) who advised that 3/4 embryos I had tested were "good" to try with. His view was all low-level mosaics should be viewed as "fine" as if they implant they are highly likely to be perfect (no fetal anomalies have been reported from continuing pregnancies with low-level mosaics). Try with any abnormals where abnormalities would not permit embryonic development if accurate (i.e. not use embryos with concerning trisomies).Hope this helps! Good luck

Side note: While I see a role for PGA-T for women with multiple implantation failure or recurrent miscarriage for fetal anomalies - personal view is going down the PGT-A route caused me more psychological harm than good. I had blasts that were not good enough for testing discarded and months of total distress when I received the results and my then RE told me it was time to discard these and go to donor eggs. I am glad I sought more specialized advice.

Here are some articles that may help:

Y.X. Zhang, J.J. Chen, S. Nabu, Q.S.Y. Yeung, Y. Li, J.H. Tan, et al.

The pregnancy outcome of mosaic embryo transfer: a prospective multicenter study and meta-analysis

Genes, 11 (2020), p. 973

Nathan R. Treff, Diego Marin,

The mosaic embryo: misconceptions and misinterpretations in preimplantation genetic testing for aneuploidy,

Fertility and Sterility,

Volume 116, Issue 5,

2021,

Pages 1205-1211

scholar.google.com/scholar_...

sciencedirect.com/science/a...

[Priyasharma in reply to Jumpppy]

Thank you for advice.. my dr has not responded to my message.. I will visit on sat.. let's see what's in my fate.

[MollyRobs in reply to Jumpppy]

hi, would you mind PM-img me the contact details of the RE you used who advised you that 3/4 of yours were OK to transfer? Thanks

[Gemstone78]

there’s a Facebook group called my perfect mosaic u should check out all the success stories there

[Mudra85 in reply to Gemstone78]

Seconding this. Plenty of people have had success with mosaics on this group, well worth a look.

[Priyasharma in reply to Gemstone78]

Yes!! I have given request to join that group.. thank you for great advice and support

[AcuFertilityDoc]

my understanding is that mosaicism exists when a blastocyst contains more than one cell line. One is euploid/normal, and the other has a chromosomal aberration. In low mosaicism the aberration is minimal and not considered incompatible with life. Some babies are born with their bodies made of two cell lines, and are otherwise healthy. And some blastos/fetuses have one cell line overwhelm the other - in other words the normal cell line can overwhelm and overtake the aberrant cell line so that your baby is born made of only one euploid/normal cell line. Here in America most reproductive endocrinologists are happy to transfer low-mosaic blastos. It seems there is a tendency for them to sort themselves out. The research is optimistic. Good luck!

[Priyasharma in reply to AcuFertilityDoc]

Thank you for advise!! My gynecologist is yet to advise anything.