Steroids in IVF

[Emineasca]

Has anyone taken steroids for embryo transfer ? Any positive results ?

[Seren0119]

Yes, 25mg. It worked for me x

[Millbanks]

Hi lovely, had 5 failed FETs, 6th transfer took 20mg prednisolone and now 19 weeks ❤️ Xx

[Jols]

Hi there, yes I am on Prednisolone 4 tablets a day (tot 20mg) since transfer and 2 tablets prior (from day 6 of menstrual cycle). It has worked for me. I have also done intralipids and Clexane this time. Good luck! X

[Zebedee1971]

Yup, I took 25mg and now have a 5 month old baby boy, I hope you're just as lucky xx

[Msze]

Steroids were the only thing that finally helped me get pregnant after SO many failed transfers and early miscarriages.

[Eternalwarrior]

Yes, 30 mg starting two days before transfer and when they saw the heartbeat, I started reducing them slowly. I am now 16.5 weeks, after over 4 years of infertility and recurrent miscarriages (5), including losing a baby at 17.5 weeks. I am also on hydroxychloroquine and heparin. Good luck! Xx

[PaulaDag in reply to Eternalwarrior]

Hi, which heparin do you use? I've heard of Fragmin and Clexane and wondering which is better? xx

[Eternalwarrior in reply to PaulaDag]

I am on Clexane xx

[Hanj10]

Yes after 5 miscarriages and 1 failed FET I took 20mg prednisolone until 12 weeks and I'm now 35 weeks 😊

[Emineasca in reply to Hanj10]

Oh wow! Congratulations! Yeah I heard this works. Did you continuously take prednisone 20mg on a daily basis ? Did you increase the dose gradually? Did you have high NK ?

[Hanj10 in reply to Emineasca]

So I took the 20mg straight away from BFP (normally they would advise prior to transfer but the clinic guidelines for covid only changed after my BFP). I came off it gradually reducing by 5mg every 3 days. I had a high Th1:Th2 ratio (T helper cells). I had the uterine NK cell biopsies with one coming back high and one normal so also had an endometrial scratch as this has been shown to help borderline results.

[Joanna-Arabella1984 in reply to Hanj10]

Hi, I’m on my two week wait, day 7.... not feeling anything. Did you? Just wondering if the steroids mask symptoms. I know this is a silly question because everyone s is different xx just going nut x

[Hanj10 in reply to Joanna-Arabella1984]

I had fairly heavy bleeding and cramping on day 7 and thought it was all over but tested day 9 and got a strong bfp. Don’t think the steroids would mask anything but I didn’t start them til after my bfp. Good luck 🤞

[Joanna-Arabella1984 in reply to Hanj10]

Thank you fir sharing ! Hopefully I’ll get the same result! I did have mild cramping yesterday but i know the progesterone can cause that x last time I got pregnant (and miscarriaged) by booms got bigger, but they have changed. Gawd I hate this 🤪🤪🤪🤪

[Joanna-Arabella1984 in reply to Joanna-Arabella1984]

*have not changed

[borhan39]

Hi I am desperate ,

Why did you take steroid ? Do you suffer from autoimmune condition?

Did you have rashes just after the transfer?

Is this something all the fertility clinics offer?

Thanks , I can’t stop crying . 😪

[Joanna-Arabella1984 in reply to borhan39]

I’m about to take them for natural killer cells! Praying it works . I’ve had lots of tests! Get them to run tests! Sending you love x

[Emineasca in reply to Joanna-Arabella1984]

I’m having blood test next week and I might have a uterus one biopsy soon but I ain’t sure of this yet. I will try the steroids as this is my last option available. I have tried everything else. Who recommend the steroids ? Was it your doctor? Which type and when Do you start ?

[Joanna-Arabella1984 in reply to Emineasca]

Hi, I have had 3 miscarriages and 1 failed embryo implantation (both pgs tested embryos). My clinic ran all tests. Everything is clear but I have high natural killer cells. This time I’m on steroids, same ones as everyone else, 20mg , I’ve had a scratch ivig infusion snd neupogen. Praying it works. I’m also on a blood thinner. They also found I have the mthfr gene so I’m now on 5mg folate. I’m sure your clinic will run all the tests. X

[Emineasca in reply to borhan39]

I don’t have an autoimmune disease no, however my mother does and my husband’s sister too. We had pot genetical testing and we are both kir Aa. Why were you crying ?

[leo1980]

Hello. I take steriods too. 25mg for the NK cells. Started on day 10 of frozen cycle. Also use inhixia for blood thinning and intralipids.Not sure if it will work - 8 days into the 2WW. Not feeling hopeful but then I am the queen of negatives! I hope the ladies have put your mind rest. It can work… sending you love

[Emineasca in reply to leo1980]

I am hopeful it will work! I heard of many ladies on immunosuppressants such as medrol or prograf or prednisone and they succeeded. I keep everything crossed for you! Did you have a high number of NK cells? Did you check it out in a blood test or did uk have a uterine biopsy ?

[leo1980 in reply to Emineasca]

Thank you.. I am so emotional I think I am going to cry..Just the blood test. Is the treatment different if it’s biospy vs blood test?

[Joanna-Arabella1984 in reply to leo1980]

Thinking of you! I’m in the same position now . Feeling really emotional. Looking for signs (which aren’t there) and only 5 days in

[Joanna-Arabella1984 in reply to leo1980]

How did it go? ✨✨✨🙏🏻

[leo1980 in reply to Joanna-Arabella1984]

Girls I was a negative. Which I expected. I was prescribed the steroids for the nk cells. So diagnosised first before it was dispensed.

[Joanna-Arabella1984 in reply to leo1980]

I’m sorry to hear that! I feel like mine will be the same. You just know don’t you. This is our third attempt. I got pregnant last time but miscarried. Hoping that all the steroids and ivig would make a difference. I hope you’re ok!! When can you try again? Big hugs x

[LSandJ]

I've asked my clinic about taking steroids but they've said due to covid protocols they aren't allowed unless there was a clinical reason. (they don't test for NK cells). I'm wondering if you added the steroid in just because it might help, or if you'd found a reason first why it might???!

[Emineasca in reply to LSandJ]

I have KIR AA and my husband has the same. Considering the new covid variant, I am sure my doctor will also refuse

[leo1980 in reply to Emineasca]

What is a KIR?