Does anyone know much about the MYHFR mutation? I have the below variant...
MTHFR c.1286A>C variant: PRESENT [HOMOZYGOTE]
I’ve been asked to up my dose of folic acid to 5mg. I’m slightly confused because many sites stress that you can’t process folic acid with the gene mutation and that you should take it in the pure form e.g L-5 Methyltetrahydrofolate. Obviously I’ll do as I’m asked and I’ll certainly be chatting to my Consultant about this during my full appointment. Just wondered if anyone else had heard anything about this?
Thanks!
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Joanna-Arabella1984
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Don't stress much, I also have 2 of the same gene mutation. My clinic did not advise me to take methyfolate, they told me to take folic acid 5mg until week 12 and after reduce it to 4. What you need to take for gene mutation is blood thinner at least until week 12 and aspirin through all your pregnancy. Take care 💕🤗
My result also came back with the gene mutation as well. I was recommended the L- 5 methylfolate instead of the folic acid by the fertility doctor. But every doctor have different procedures so wouldn't be too worried. Good luck
I have also questioned 5mg folic acid vs 800mcg methylfolate and my consultant said the former is the gold standard, tested in clinical trials and proven to be effective during the years. The latter is a novel addiction that seems to work, but she would suggest the former!
With the mutation, you can still process folic acid (these mutations seem to be pretty common), but you are not so effective, so the need for a higher starting dose (and this is just in case, there is not a clear cut answer yet)!
Thank you, this is really helpful! I also read you need folic acid specifically, to prevent defects etc. Just probably over read on this one 🤪🤪🤪. Do you use a particular brand for your folic?Many thanks,
I used a brand I have bought in Greece (my first two cycles were there). I think any will do the trick, but I think that to buy it in the UK you need a prescription?
They are good someone recommended Thorne to me too but going to carry on with what I have for now. Changing meds etc can be a headache and I’ve noticed it on my body when I’ve changed my supplements. X
Also forgot to say there is some research about low amh and mthfr as it’s beloved to be genetic and or immunology issues. Hence why some women my age have low amh or egg reserve. So carry on with it daily as I had a recent test and I noticed my levels had risen! Crazy who knows why or what! But thought I’d share as I have low amh and mthrfr x
That’s amazing! I have love amh for my age too! I’ve now been tested for multiple miscarriages and I gave high killer cells in my blood. I’m doing that intralipid infusion and steroids on my next frozen transfer... but I’ve decided to have another egg retrieval first! Whilst I’m 37... 🙏🏻
Aww good luck my lovely I’m about to start my nortisterone today! 🧘🏾Did you get the nk cell biopsy or just bloods? I was looking into intralipids but my clinic said to hold off until after this round and see what this brings xxx
I start mine tomorrow. They did a biopsy too. Weirdly my womb was normal but my bloods tested positive. He wants to throw everything at it as it’s my last pgs tested embryo from last year. I got 3 that were tested! X
Yes it’ll be round 2 fresh cycle I ’m frightened about it all but I have to see what happens hate the disappointment at the end of it. I had one round so far and had two good embryos but neither stuck. X I’m tempted to get nk cell testing done privately with liverpool clinic but can’t with this round starting. I’ll keep my options open for if it doesn’t work. Did you find the biopsy hurt? I’m worried! X
I’m sorry it didn’t work, I feel your disappointment. This is all about resilience. It’s amazing you got two great embryos! I did my biopsy without any pain killers as didn’t realise it would hurt. Honestly, wasn’t that bad, I mean I’ve had better days, but Just lie back and breath. 🤪.
I don’t lovely - the way I found out was via two independent consultant ions with harley street and another clinic in liverpool ( neither which are local to me) and they reviewed all my notes and said low amh could be genetic, their could be immunology or genetic factors involved and it’s interesting as they said egg reserve or quality can be impacted on by thyroid disorders, mthfr low vit d, genes 🧬 and or it could be an early indicator of menopause but they couldn’t really say if it’ll happen as I’m still having regular periods etc. All I know is my amh was .60 and fast forward three mths I’m on 2.74 which is still low range but I think it helped a lot x
I can call them and ask them to send me research on it if you’d like x
Gosh you are unbelievably sweet! No I’ll take your word. Actually sometimes reading too much science stuff can freak me out. Ok, having said that, I’m reading and listening to Marisa peers , how to get pregnant. It’s helping me stay strong and lowers my anxiety. I don’t want to come at this full of fear . You might like it? That’s incredible how much your levels have risen! I do know amh is only an indicator of egg reserve, my mum and grandmother didn’t get their menopause until later in life and that’s a better indicator.
Really hope we both get lucky this time! It’s so tough and completely takes over, doesn’t it! X
It does! I’m keeping things crossed for us both! And yes they usually ask about mother’s menopause and cycles which is good to know. Although my mum started her period at 13 and mines was 9! 😒😩…. Let’s get our cycle game on! And let’s try to be as positive as possible and not read stuff on the net as much unless it’s for self care or meditation purposes xxx
Definitely! I actually stopped following stuff on here but saw you responded to my question. I became a bit obsessed with readings people’s stories. But now I’m trying to get my head into a different space! I’d love to hear from you though. Sending lots of love and strength x
Likewise be lovely to check in and support each other ! I will private message you than group posts and see how you are. Like wise I’m happy for you too. Lots of love and luck xxxx
Just a thought, but have your clinic recommended an endometrial scratch? That can improve your chances of it sticking too! Definitely keep me updated. I guess you’re doing a fresh transfer straight after? Mine will take longer as I’m doing a frozen transfer and might have a rest in between xx
Hiya! So I’m due to have an endo scratch this Friday! Have you had one before? Did it work? Xx clearly I’m a bit anxious about it I had an awful experience with a HSG! Ouch! Legs crossed
Yes, I got pregnant after mine, unfortunately it didn’t work out but a step in the right direction. Actually I had that and a hycosy (think that’s what it was called) under anaesthetic. I was awake in my biopsy though. It’ll be worth it!!! X
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