Repeat failure implantation

[Cally_uk]

Am prepping for my final frozen embryo

After 7 cycles of ivf

We get good quality but still no luck

The pressure is hard to ignore

If this time fails I can’t see donor helping it could be end of road any one had similar with success after repeated failure to implant

Positive hope stories needed

[XOXO13]

Hey, fingers and toes crossed it’s 7th time lucky 🍀

Have you had any tests or investigations to determine by you may be experiencing repeat implantation failure? I’ve just had my third transfer end in a chemical which is the furthest we’ve gotten with IVF, and we are having genetic testing of both me and my husband and I’m also having a hysteroscopy. I know other women on here have had further tests such as immunology and ERA - have you explored these?

Best of luck to you xx

[Cally_uk in reply to XOXO13]

Sorry to hear this

Tests have never been suggested to us by our consultant.

Believe we may have had chemical pregnancy also but our centre says to test day 14 past transfer meaning this may not be picked up & tests offered.

May I ask what I’d your hysterically checking? All the best

[Marisa32 in reply to Cally_uk]

If they never suggested any tests, then they have no way of figuring out what the problem is. It could be abnormal embryos due to egg or sperm issues, it could be something completely different. Either way, I would do some basic investigation and tests before blindly going into more transfers. Good luck!

[XOXO13 in reply to Cally_uk]

I’m surprised you’ve not been offered further testing and I would definitely push for this because it may uncover something that can be treated with a slight tweak to your meds.

My doctor personally doesn’t believe that NK cells impact implantation and it is controversial within the fertility field, and whilst on this occasion we are trusting our doctor and therefore not testing for that, I do agree with the others in that it’s something worth exploring if all other tests come back normal. I’ll certainly be pushing for it if my 4th transfer doesn’t work.

Best of luck to you x

[Zebedee1971]

Do you mind me asking what your amh is, and whether your partners sperm has come back normal?I had an amh of 16.5 at 36 years old and had loads of early miscarriages/chemicals. But it didn't make sense because our results always came back fine... I got tested for nk cells and it worked for us. I always had a feeling it was my body rejecting the pregnancies rather than the embryos not being viable.

If your amh is good, and no issues with partner, could be worth looking into immunology,x

[Millbanks]

Sorry to hear you’re feeling the pressure. If you’ve not had any tests done I would absolutely look in to the following;

ERA/ALICE/EMMA - it could be your transfer window is wrong, or your uterine bacteria isn’t at the right level.

Immunology: you may have high levels of cytokines or NK cells which can attack foreign bodies- this is treated with steroids.

You could have polyps in your uterus which can affect implantation- a hysterocopy as xoxo13 says - will show you this.

Also check your progesterone levels. I’d look at discussing these with you Dr xxx