AOA - has anyone had success with this? - Fertility Network UK

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AOA - has anyone had success with this?

Amy1122 profile image

I have had very little fertilisation.. out of 10 mature eggs only 1 has ever fertilised in my last 2 ICSI cycles. My clinic recommended AOA but I appears very new - has anyone had this?

11 Replies

I havent personally but I've been on this site a long time and seen others have success so it can make a big difference.xx

It’s probably a problem with your clinic lab. They are using techniques not suitable for your eggs

Hi Amy, this just happened to me too. Heartbreaking isn’t it? I’ve got my appointment with my clinic next week to discuss and I’ve heard a lot of about AOA so will see what they say to that. Sorry you’re going through this.x

Hi Amy, yes our clinic recommended this when we changed clinic and after 2 failed attempts with poor fertilisation. For the price I think it's well worth a try. Our first 2 attempts without AOA only 1 fertilised, then using AOA we had nearly 50% fertilisation. 9 eggs out of 20 fertilised. I'm not sure whether it was soley down to this as we did have a few more changes but I would recommend it xxx

Just had the news yesterday that out of 10 no fertilisation occurred with ICSI. the lady I spoke to said this is very rare and it only happens to 1-3% of couples which made me sick to my stomach, I mean reading stories on here I see it’s happens and I’ll definitely be asking for AOA for sure! My husbands sperm count is super low that’s why we were put forward for ICSI never in a million years did I think I’d get that news yesterday as I’ve never had any sort of problems with periods and had a good amount of good sized eggs (I’m 38) when I’ve had the AOA I’ll write back on here about the outcome as like I said zero of mine were not fertilised. Xx

Amy1122 profile image
Amy1122 in reply to Fl23

Hi, I was the exact same yesterday. I had the call, 10 mature eggs did not fertilise. I even used AOA :( x

Fl23 profile image
Fl23 in reply to Amy1122

Oh no really so sorry!! I have just spoken with the embryologist at the clinic literally 10 mins ago and asked if there was anything wrong with my eggs ie immature, too mature, too fragile too small etc he said no they all looked fine and were a good size and he said if there was something they would note it but there was nothing and as they are dealing with lots of eggs everyday they know if something is not right with them , I’m thinking it might be my husbands sperm but he said they were swimming and looked ok, I read last night that it might be due to the fact that the sperm has not decondensed which would cause failed fertilisation due to the DNA of the sperm remaining locked in the sperm head. it’s really frustrating they can’t tell you more. I mean 10 eggs that look great for them not to fertilise with icsi is very worrying as they obviously can’t tell you what goes on inside the egg when it’s implanted. How are your eggs did they tell you? Xx

Amy1122 profile image
Amy1122 in reply to Fl23

Yeah! Still try AOA though because I’ve read great things about it.

When they called me I couldn’t stop crying, so I couldn’t ask all the question - this is my 3rd round .. this happened to me on the first round! 2nd round only 1 fertilised!! I’m going to get my husband booked for a dna fragmentation test.

They’re calling me back on Friday and I am going to ask them how my eggs were. A professor is reviewing my case so I’m interested to understand what they think!

I just can’t believe it xx

I was crying also I was in total shock when she said zero have fertilised and it’s very rare, I also couldn’t ask any questions that’s why they phoned me again the day after the results, so is this right on your first round of icsi you had zero fertilisation? and the the second round of icsi with AOA you had one fertilised? Is that correct? I’m also gonna book my husband in for a dna fragmentation test! Your story is very similar to mine by the looks of it xx

Amy1122 profile image
Amy1122 in reply to Fl23

So first round I have 0 with ICSI. Second round I had 1 with Icsi but I didn’t try AOA.

3rd round I have 0 with ICSI and AOA.

I think people prepare you for that negative pregnancy test but no one prepares you for no fertilisation!! Xx

Fl23 profile image
Fl23 in reply to Amy1122

I know, no one said to me or even mentioned to me that I could have zero fertilised eggs that’s why I was totally shocked!! I’m seeing my fertility doc next week so I’ll give you an update of what he says if he sheds any light on it all which I’m doubtful after all this, definitely ask about the condition of your eggs, they can tell if they are poor quality etc but in my case she said it was all fine, you had one fertilised the second time which gives you some hope but obviously we both would like to know exactly what the issue is, I’ll keep you informed as to what they recommend as it sounds like you situation is similar to mine and maybe help in some way xx

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