Mosaic embryo

[Crabonks]

Hi all, my PGS test came back - out of the two embryos I had to send off for testing, one was complex abnormal (meaning more than three abnormalities I believe?) and the other one was low level mosaic. The genetic counsellor told me this could mean the embryo corrects itself or I could miscarry or give birth to a baby with XXX syndrome, which mercifully, is the mildest of all chromosomal abnormalities. I am just wondering if anyone else has had the same diagnosis or could empathise with me? My doctor is happy to transfer my embryo...and said sometimes, with these tests, "sometimes you end up knowing more than you need to know"...that tells me something eh?

[Ivfgotadream]

Hi there I had exactly the same result one complex abnormal and the other a low level mosaic monosomy 11 (so some cells missing chromosome 11). I was allowed to transfer it but it ended in a BFN.

Do you have your report saying which chromosome is affected on the mosaic? There is a hierarchy of chromosomes - some are better to transfer than others and have pretty good success rates? Also could be that your mosaic is a segmental which also has good success rates? Having a missing (mosonomy) chromosome is better than having an extra one (trisonomy)

The information/science can be a bit overwhelming- there is a good Facebook groups

I joined though called “My perfect mosaic embryo” - lots of knowledgeable members from America where it’s much more common to transfer mosaics and abnormals with success x

[Crabonks in reply to Ivfgotadream]

Hi there, thanks for the reply. I'm sorry to hear it didn't work for you and hope you achieve a better outcome soon. There is an extra X chromosome (XXX) in 20-40% of the cells. I'm not sure which ones have better success rates - do you know? The counsellor did say that 90% of girls born with the extra X don't even go diagnosed as the syndrome is the mildest of the chromosomal abnormalities. There's also the hope that the embryo cells correct themselves as there's a smaller amount of them I did join the facebook group you mention actually and got a positive response to my question regarding mosiacs. I'm just crossing my fingers she sticks

[ToughCOOKIE78]

Hi hun, I’m so sorry to hear about your PGS results. I had the same and decided not to transfer, after having had a mmc at 11weeks didn’t want to risk another one!

Also, I don’t know your age but I’m 40 and at this age it’s very unlikely that the embryo corrects itself....very unlikely from 35 years of age onwards...

Wishing you good luck for whatever next step you’re taking 💋💋💋💋💋💋💋🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻🙏🏻

[Crabonks in reply to ToughCOOKIE78]

Thanks for the reply. I am 42...so that doesn't sound too promising. This is my first go and I've never been pregnant before so I do really have to give it a try. I do have another go if this time doesn't work but I'm feeling positive. 🤞🤞

[fay2399]

Is risky but you can do genetic testing at 10 weeks? Is there worse case scenario? Are you able to repeat egg retrieval to see if you get options?

[Crabonks in reply to fay2399]

Hi fay2399. Yes, I do have another round if necessary - in March/April. My partner had a vasectomy three years ago, just before we met - which the doctor said, may have contributed to the lack of fertilisation. They had to 'go in' with a needle five times before they decided to cut him open and get what they needed. The embryologist then had to put some solution on his sample to tell which sperm where alive - the glowed - of which there weren't as many as they'd hoped. So doc told me if we do ICSI next time, something will likely need to be done in terms of his sperm or we will likely get the same result. By the 10 week test, do you mean the amnio? I'm not sure I could do that test - the thought of that giant needles scares me - for the baby as much as for me!

[fay2399]

No I didn’t mean the invasive one! There’s blood test to tell if genetic issues. If you have another round then maybe is good to see what happens then decide. I hope best happens at the end xxx