Mmc results in... Trisomy 9. Anyone had this and gone on to have subsequent normal birth?

[Jessy1280]

Discovered my amh has dropped from 45.2 to 24.3 in just 11 months. Shocked at the dramatic drop but still high for my age at 39.

Had the results of my mmc today. Trisomy 9. Been told this is rare and chance of recurrent miscarriage low. She was a baby girl. Although has been found wrong with me fertility wise, I'm wondering if I'm to blame or caused this. My partner fathered two healthy children before his vasectomy. I know his sperm is now poor following vasectomy reversal but can't help wondering if I'm a carrier or some abnormality? Or just a one off cruel occurance?

Starting cycle 3 a week tomorrow and I'm terrified of getting no embryos, of a BFN or another mmc.

Anyone has anyone had trisomy 9 and gone on to have a healthy full term birth. Feeling so low and like time is against me. Xx

[Hidden]

I can’t answer your question ( hope someone else can) but I’m so sorry for your loss. Hopefully your clinic will explain this better & devise a plan.

Miscarriages are truly awful.

We chose to see our baby wasn’t quite right ( maybe too good for this cruel world?) but didn’t stop it from hurting.

Fertility is complex but no one is to blame ( no one would chose to have fertility issue!)

Miscarriage are normally a one off occurrence ( I hope yours is just that even 1 is too many)

I had my daughter at 37 & half I know it’s not 39 but it’s not young either!) Lots of women have children later in life & there’s no reason you shouldn’t.

I wish you best & hope this cycle brings you your take home baby ❤️xxx

[Mmmpudding]

Hi Jessy I can’t answer your questions but just wanted to wish you the best of luck for your third cycle! At least you have very high amh and a good number of eggs. So you still have a good chance. Stay calm and distract yourself from anything ivf / baby b fertility related xx

[Hidden]

Sorry to hear this Jessy. I don’t have a success story but want to wish you luck with your next cycle. Our baby had trisomy 21 I was 34 at the time the embryo was frozen. We have been given a 1% chance of this happening again because it was a chance event x

[Jessy1280]

Thanks for your replies. I'm worrying so much of this happening again. I'm convinced there's something wrong with me despite what my clinic says. Like I'm using opks again. The digital one reads high but when I use paper opks there's no second line.

On paper I'm an ivf dream. High amh, respond well to meds, no endo, pcos, gynae issues, normal periods, normal 21 day progesterone. The hospital are now talking about genetic counselling but my OH is really unsupportive about this.

I'm starting third cycle a week weds and just can't face another BFN or mmc. Last cycle we literally got just one embryo out of 13 eggs. My oh has started taking supplements again but it's a bit late in the day now. 😢. Got two embryos on ice from cycle 1 (a hatching 5ba and a day 6 bb) but I'm struggling to afford it anymore. I'll never give it up but it's testing us to the limit as a couple. I don't know how anyone deals with this over and over x

[Hollyhughes]

Hiya, my third miscarriage was Turner syndrome so not trisomy but another chromosome issue all the same, it was a baby girl too. Chromosomal causes of miscarriage are usually completely random with a low chance of reoccurrence (although increases with age as you’ll know) but if you want some reassurance maybe get genetic testing done for yourself and your partner - my husband and I did that and the tests came back fine which put my mind at ease. I’m 39 too with a very low amh level so I focused on doing everything I could over 6 months to improve my egg quality and hormone profile as well as my husbands overall health too. I’m now nearly 24 weeks pregnant - still a few weeks to go but glad to be this far after all the heartbreak. Wishing you lots of luck for your next cycle xx

[Jessy1280 in reply to Hollyhughes]

Thank you for your reply. The hospital are referring me to genetic counselling. I'm really open to this. Driving me crazy if that's why I've never been pregnant prior to my mmc. However my partners sperm is poor following his VR Sept 2018. It's worked in terms of reconnecting the tubes and sperm is present but its still so poor with hugely fluctuating count and motility.

It's reassuring that ladies do go on to get healthy pregnancies

Big congrats on your pregnancy xxx

[Mara84]

Hi dear, I have similar experience my second mmc was Turner syndrome... very difficult time. However I felt better after I found out the reason behind mmc...

I was feeling just like yourself, so worried that it might happen again so my husband and I did a CarrierMatch test and it really put our mind at rest.

I do wish you the best of luck, I’m starting my cycle tomorrow! Hopefully this is it for both of us. Xx

[Sayusayme]

How did you rule out trisomy 9??

[Missl73]

Hey Jessie, any Trisomy is just a random mutation as the cells divide there is absolutely nothing you could have done to cause it, it’s just bad luck. I miscarried my first (also a girl) due to Trisomy 16 but I went on to get pregnant again a few months later with a FET and I’m now 24 weeks and everything with this pregnancy is totally normal and all my screening results came back very low risk. It hasn’t been easy during early pregnancy as I was convinced it was going to happen again but the statistics are overwhelmingly in your favour. Only 1-2% of women go to have recurrent miscarriages - basically its rare. Remember on these boards people mostly post for support so you can end up thinking things are much more common than they actually are. The fact you successfully conceived even though you miscarried also makes you more likely to go on to conceive again so try and focus on these positives. I’m sure you will also get your rainbow xx

[Libsie3103]

Thank you so much for this. I also recently found out my MMC was down to Trisomy 9 and was told I had a 1% chance of it happening again. It’s good to hear your story and that your 24 weeks along - good luck with the rest of your pregnancy xx

[Cinderella5]

Hey Jessy, I'm so sorry that you're going through this stress and worry however as the others have said these things are a random event with a very, very low chance of happening again. Hopefully you will be referred for some genetic counselling which can help reassure you! Hugs.xxx

[Jessy1280]

Soooo reading into trisomy 9, it seems you can have mosaic, partial or full trisomy 9. Apparently rare and not an inherited condition which is a relief. Only 2.5% of pregnancies end this way so that chances are that it occurred during fertilisation. Not sure how accurate all this is but just going off what I've been reading.

Since this discovery I've found it hard to take in. I knew it'd be trisomy something or other but I don't think I was prepared for it being one of the rarer ones and the fact that she was a girl. I wanted a girl and I felt she was a girl. Turns out she was. I know if she had survived (highly unlikely), she'd have no quality of life but I still wanted her soooooo badly x

[sun-and-rain]

Knowing that it was a chromosome/trisomy issue with your loss should in my view be a relief. That means there is nothing about your body, your uterus, hormones etc., impeding your so longed for pregnancy! As others have posted, most trisomies happen for no particular reason and are not generally known to be recurrent events, even though the risk of it happening increases with the age of the mother. But that's totally independent of the _genes_ of the mother. Mostly it's bad luck and coincidences...

About genetical counselling I'd be a little more sceptical. Why? Because it's all great when it turns out negative (=no findings). But what about if they find something? Are you really ready to know and take the consequences? In which way will a finding affect your life, your relationship, your future decisions? No such test will ever say 100% chance of having a child with some abnormity. Won't you still cling to the chance of your baby not carrying the condition? Won't you still be devastated if it turns out it does - even if it's even before ET? Is there any chance it could be better not to know, just to hope?

I have no right answer for you about what to do, I just think it's so important to think thoroughly through these dilemmas! We tend to think all kinds of screening is a good thing to know that everything seems good, almost forgetting about the possibility of an unwanted and unexpected finding...