HELP!Recurrent Early Miscarriage All Tests Clear Except thyroid antibodies.

Hello as the title says... I have had 4 very early miscarriages around 4 weeks after a positive pregnancy test and one at 8 weeks. Antiphosphllipid test came back clear -no issues, pelvic scan clear lining day 21 was 7.7 mm. The only test that came back with a slight 'oh' it could be this is the one doctors don't treat. There is currently a trial based on this at the moment with the NHS; this is the thyroid antibodies test. My test came back 109 Thyroid Peroxidase antibody but my TSH is 2.82 which doctors consider normal and are not willing to treat. I managed to get private trial prescription for levothyroxine to see if this may be the issue. Hopefully it's this and I've found the reason. Do these antibodies effect implantation?? Could this be the reason . Ovarian reserve is good too. So opinions and experiences please??????

[Tlove]

Thyroid function is really important in pregnancy. I was finding it difficult to get pregnant and then once my thyroid was controlled with eltroxin I got pregnant quickly, so maybe this does indicate that implantation is affected by thyroid. But all 3 pregnancies ended in mc. However, I'm different to you in that my AMH is low and I have APS, which also contributed to the mc. I would think that once thyroid function is under control, you will be more likely to become pregnant and hopefully as you don't have any other underlying issues, it will stick. But as soon as you get a positive pregnancy test, you have to get thyroid function tested again because it changes in pregnancy. Even of you're only borderline for thyroid function, they should put you on eltroxin. I was borderline on my first test and have been on it since because my GP doesn't 100% trust the readings on the blood test. You'll have to be tested every few months as well and vary the prescription as necessary because it can change.

It's good news that they didn't find anything else, although I know you are probably wishing they had so you could have answers. If, God forbid, it were to happen again, you could have a d&c and get the tissue analysed for chromosomal disorders. This is usually the cause for early unexplained mc. I regretted not doing this as it would have given more information on what had happened.

[pm27]

It seems to depend on your clinic's protocol. Some clinics insist on below 2.5 but others don't. My second consultant wanted my levels to be 2.5, they weren't much higher than that, but my GP agreed to prescribe Levothroxerine and to have blood tests redone and my levels dropped. We were self funding treatment but I got that prescription on the NHS.

Unfortunately it didn't make the difference for me.

I'd had recurrent miscarriage screening after natural conceptions ended in miscarriage and NHS were happy with my TSH.

[DianeArnold Partner Nurse Fertility Network UK]

Hi Orangepie. As Tlove says, all your hormones, including your thyroxin need to be in sinc to secure an ongoing pregnancy, so best to query it - and lots of luck! Diane