I'm 8 weeks into 9 months of Zoladex. My 3rd injection is due tomorrow. I have been on Tibolone since day one for the side effects. Well, it doesn't seem to be working! I've got horrendous mood swings, hideous headaches, joint pain & hot flushes. I still have have endo pain as well. I've asked the GP today if I can try another HRT but she won't change it without checking with the consultant that originally prescribed the treatment. She couldn't tell me how long it would take as she's busy! I was just wondering if anyone else is on a different HRT to Tibolone when on Zoladex & has it made a difference.