Acidosis related to use of metformin seen only in those with severely decreased kidney function.
Metformin is the first-line medication for treatment of type 2 diabetes in adults and the fifth most commonly used drug.However, there has been a longstanding concern in the medical community about prescribing metformin for people with both diabetes and CKD because it may cause lactic acidosis, says senior study author Morgan Grams,
Results of a large-scale study suggest that the oral diabetes drug metformin is safe for most diabetics who also have chronic kidney disease (CKD). The study of more than 150,000 adults by Johns Hopkins Medicine investigators found that metformin's association with the development of a life-threatening condition called lactic acidosis was seen only among patients with severely decreased kidney function.
A report on the study appeared online June 4 in JAMA Internal Medicine.
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