IR (Insulin Resistance) is more due to excess body fat, glucotoxicity and lipotoxicity. Weight control and good blood glucose control does reduce IR fairly rapidly.
Glucotoxicity refers to the structural and functional damage in the beta cells and target tissues of insulin, caused by chronic hyperglycemia. These alterations cause a lower hormonal secretion and action (insulin resistance).
Lipotoxicity refers to the damage caused by persistently high free fatty acid levels, as a consequence of triacylglycerol catabolism.
This toxicity can be implicated in the pathogenesis of type 2 diabetes and in the secondary failure of oral hypoglycemic drugs.
Since many of our patients present with this apparent glucose toxicity, it is important to treat to target as quickly as possibly and this is where many clinicians are choosing short term use of insulin to reduce both the average glucose levels and reduce the associated glucose toxicity….
Del Prato et al at the Department of Endocrinology and Metabolism, Section of Metabolic Diseases and Diabetes, University of Pisa, Pisa, Italy found that short term use of insulin improved both glucose levels and insulin resistance.
The use of insulin for both glucotoxicity and lipotoxicity is often only temporary and if used aggressively enough will work to reverse some of the damage done by the high glucose level.