nopr.niscair.res.in/bitstre...
The hypolipidaemic drugs have attracted considerable attention because of their potential to prevent cardiovascular disease by retarding the accelerated atherosclerosis in hyperlipidaemic individuals. Statins are the first choice drugs for primary hyperlipidaemias with raised LDL and total cholesterol levels, with or without raised triglycerides levels, as well as for secondary hypercholesterolemia. Statin therapy is commonly associated with liver damage in terms of elevated aminotransaminases...................
................ Statins therapy was associated with liver damage in terms of markers of hepatotoxicity, i.e. elevation in serum bilirubin, AST (SGOT), ALT (SGPT), and serum alkaline phosphatase, but the clinically significant hepatotoxicity caused by statins remained absent.Katuki (Picrorhiza kurroa Royle ex Benth.) processed in Guduchi (Tinospora cordifolia ) have proved to be effective Hepatoprotective drug as both components have not produced statistically
significant hepatotoxicity, i.e. elevation in serum bilirubin, AST (SGOT), ALT (SGPT) and serum alkaline phosphatase in the patients registered for the current trial. Thus, it can be concluded that Katuki (Picrorhiza kurroa Royle ex Benth.)processed in Guduchi (Tinospora cordifolia)
are effective drugs in checking the progress of the drug induced hepatitis
especially by statins.
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