Clinical evaluation of the hepatoprotective effect of Katuki (Picrorhiza kurroa )

The hypolipidaemic drugs have attracted considerable attention because of their potential to prevent cardiovascular disease by retarding the accelerated atherosclerosis in hyperlipidaemic individuals. Statins are the first choice drugs for primary hyperlipidaemias with raised LDL and total cholesterol levels, with or without raised triglycerides levels, as well as for secondary hypercholesterolemia. Statin therapy is commonly associated with liver damage in terms of elevated aminotransaminases...................

................ Statins therapy was associated with liver damage in terms of markers of hepatotoxicity, i.e. elevation in serum bilirubin, AST (SGOT), ALT (SGPT), and serum alkaline phosphatase, but the clinically significant hepatotoxicity caused by statins remained absent.Katuki (Picrorhiza kurroa Royle ex Benth.) processed in Guduchi (Tinospora cordifolia ) have proved to be effective Hepatoprotective drug as both components have not produced statistically

significant hepatotoxicity, i.e. elevation in serum bilirubin, AST (SGOT), ALT (SGPT) and serum alkaline phosphatase in the patients registered for the current trial. Thus, it can be concluded that Katuki (Picrorhiza kurroa Royle ex Benth.)processed in Guduchi (Tinospora cordifolia)

are effective drugs in checking the progress of the drug induced hepatitis

especially by statins.

10 Replies

  • The opening statement implies that high cholesterol levels cause heart disease. Dr Malcolm Kendrick refutes this, stating that Irribarren's hypothesis has been disproved time and again, yet is still widely used by the medical profession.

  • Concerned topic is all about statin....and liver damage.... if cholesterol is problem or not is debatable...

    Ok....I agree lol...cholesterol is most important for body functions.....

  • Not having too much fructose or alcohol is hepatoprotective ;-)

  • agreed Concerned they say fructose is more harmful than alcohol....

    Once you get diagnosed with NAFLD .....and diabetes....and when docs put you on statin(its standard protocol they say) you have perfect recipe to get your liver damage....and remain diabetic for life time....

  • pcsk9 inhibitors the next generation (replacement) of failed statins. Now there will be plethora of advertisement like "clinical research to show how this is better and statins are bad -- just because patents expired/expiring :)

    Will cost $14,000/person/year. So unless they sell the scare, how will they make $14,000/year/person?

  • It'll be interesting to see how they differentiate between the harm done by statins and the harm done by lowering cholesterol.

  • They will brush it under the carpet and then a series of websites will keep spinning the story (or LIE) over and over again thru ghost writers till it becomes a new truth. ;)

    Jansen funded a research to show how Invokana is great for kidneys and the outcome of the study is anyone's guess, when the seller also becomes the funder of the studies. Trying to dilute the news of drug causing DKA in type 2 with normal blood glucose levels also. It's like Coke funding studies to show that sugar is harmless :)

  • Don't they still give fibrates along with statins and when the side-effects of statins are too severe?

  • As discussed in the link, they smartly use the relative % reduction to market the real nonsense. Dr Uff Uff ravenskov also stated how this is used to exaggerate the +ve side of statins.

    As noted in a example in the article, a reduction from 3% to 2% is just 1% change but 33% benefit is what gets published and spun a zillion times on the network of sites funded by the drug companies. This is how these so called experts fool the innocent to keep the cash registers ringing.

  • Bhai log....are we diverting???? This url is about usefulness of Kutki....

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