Galvus met 1000 mg

[Ruchika31]

My husband is taking galvus met. 1000 mg two times a day. Is that too much. His fasting ranges from 100-125 and pp 175-200. What side effects does it have .

Thanks

[RAJIV]

Sorry to say Doctor its not only Metformin its Vildagliptin50 mg Along with Metformin 1000mg. So the layman confuses at your post. Now for all side effects refer to >>

Vildagliptin, an oral anti-diabetic drug, is indicated for the treatment of type-2 diabetes mellitus with other similar drugs. Vildagliptin increases the circulatory levels of two incretin hormones in response to food intake and glucose metabolism.

Pharmacodynamics

Vildagliptin is a dipeptidylpeptidase-4 (DPP-4) inhibitor that improves glycaemic control by preventing DPP-4 from inactivating the incretin hormones glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide, thus prolonging incretin activity in response to ingestion of nutrients. This increases insulin sensitivity, decreases glucagon secretion and improves β-cell function.

Pharmacokinetics

Absorption: Rapidly absorbed. Max plasma concentrations achieved 1-2 hr after oral admin.Oral bioavailability: About 85%.

Metabolism: Metabolised by hydrolysis.

Excretion: Mainly excreted in the urine.

Vildagliptin Indications / Vildagliptin Uses

No information available

Vildagliptin Adverse Reactions / Vildagliptin Side Effects

Vildagliptin can cause unexplained weight gain, risk of foot ulcers or skin blisters, hypoglycemia, fatigue, headache, tremors, dizziness, and fluid retention.

Precautions

Vildagliptin is contraindicated in patients with severe hepatic disorders, type-1 diabetes, dialysis-dependent severe renal disorders and diabetic ketoacidosis.

Vildagliptin may cause serious dizziness or fatigue. Do not drive vehicles or operate heavy machineries while taking Vildagliptin. Monitor blood glucose levels and LFTs while taking Vildagliptin.

Special Precautions

Renal impairment.

Other Drug Interactions

Vildagliptin may interact with other drugs including ACE inhibitors, thiazide-like diuretics, thyroid hormones, sulphonylureas, corticosteroids and sympathomimetic drugs.

Dosage

or Type-2 diabetes mellitus (Adults):

Consider daily administration of 50 mg of Vildagliptin with metformin or thiazolidinedione in the morning. The maximum daily dose should not exceed 100 mg/day.

Food(before/after)

Vildagliptin should be taken after food

List of Contraindications

Vildagliptin and Pregnancy

USFDA pregnancy category B. Vildagliptin may not cause harm to an unborn foetus. Before Vildagliptin treatment, the patient should discuss with the physician, if they are planning for a pregnancy.

Vildagliptin and Lactation

It is unclear whether the drug could pass through the breast milk to a breast feeding a baby. Consult a healthcare provider before taking Vildagliptin, if you are nursing mother.

Storage

Store at 25 to 30°C