I just put the following in response to comment by members:
Philip & Indiacratus: Over time synthetic sources for active ingredient replace those extracted from natural sources. In the early stage majority are from natural sources. And they have side effects, nonetheless.
I regularly take large dose of ALA in form of Flax Seed and it has side effect. Similarly, Circumin has side effects. Currently one (corollary method inference) study suggests Stevia may help partial reverse of diabetes but I say if sufficient research is done, the side effects may get uncovered. I believe there almost is nothing effective that does not have side effect. It is a matter of optimizing positive effects versus side effects.