Inositol, no brainer for PD.

[38yroldmale]

Inositol is a complete no brainer I take 1-2 grams 3-4 times a day. Phytic acid is a derivative Of inositol. Helps the liver, great for sleep and OCD. NAC and Inositol have been studied for anxiety, depression and OCD. The mechanism of action of inositol is unclear, but it must be good because the only effect is calmness.

functionalmedicinecharlotte...

[park_bear]

I did not find the video convincing because the matter was not at all straightforward and he did not list his references, so I was unable to evaluate them for myself. What came up from searching the subject:

onlinelibrary.wiley.com/doi...

Short Report

Inositol is not therapeutic in Parkinson's Disease

Alex Mishori, Joseph Levine, Esther Kahana, R. H. Belmaker

First published: 23 June 1999

Abstract

"Inositol 12 g per day was added to ongoing anti-Parkinson therapy in a controlled randomized cross-over design in nine patients. No therapeutic effect was found. "

[Bolt_Upright in reply to park_bear]

Here is the entire paper from 1999: sci-hub.st/10.1002/(SICI)10...

The way I read this, the trial was 10 people divided into groups of 5. 5got inositol for a month, 5 got placebo for a month. Then they switched and the other group got placebo and the other got inositol.

I don't have any confidence in a 1 month study. I would expect, even if the treatment was effective, symptoms might continue to get worse for maybe even months while the treatment is slowing the slide.

I imagine it as a car with no brakes rolling down a long steady decline while you look for some way to brake. If you find some way to create some friction it will still take time to stop the descent.

I believe in picking a horse and, unless you start declining faster than before, ride that horse for at least 6 months. I have a high school degree and no medical training.

[park_bear in reply to Bolt_Upright]

I had been unable to access the full text so thanks for that assist.

I have to agree one month is not long enough for a disease modifying therapy. So this study is a data point, but does not exclude the possibility that phytic acid might be helpful.

On the other hand, I have been consuming a daily breakfast porridge of almond meal and wheat bran, for over 2 years. Both of these are high in phytic acid, and as far as I know it has not made any difference in my Parkinson's. reference: healthline.com/nutrition/ph...

I remain unconvinced by the text cited in favor: "IP6 and its potential neuroprotective roles in preventing or slowing down the progression of PD". Emphasis added. Until someone comes up with lab or clinical results this is speculative.

[Bolt_Upright in reply to park_bear]

I agree PB. I am not "convinced" either. I am not "not convinced" either.

I am still testing my existing stack. In about 6 years I should know if it is working.

[Bolt_Upright]

I used to take Insositol (I knows it all). I don't think I stopped for any reason except I was trimming my stack.

Neuroprotection of phytic acid in Parkinson’s and Alzheimer’s disease 2023 sciencedirect.com/science/a...

Abstract

Parkinson’s disease (PD) and Alzheimer’s disease (AD) are two of the most common neurodegenerative disorders, characterized by the progressive loss of neurons. These two diseases share common molecular mechanisms, including brain iron accumulation, oxidative stress, protein aggregation, and neuroinflammation. There is no effective therapy to halt the progression of PD or AD. However, accumulating evidence suggests that the consumption of phytochemicals may delay the onset or slow down the progression of neurodegeneration. Phytic acid, is a dihydrogenphosphate ester of inositol. It is stored as phosphorus in plant seeds like cereals, legumes, and nuts. Traditionally, IP6 has been considered an anti-nutritional factor due to its mineral chelating properties, which can reduce mineral absorption. Recent research also indicates its potential benefits for neurodegenerative disorders. In this review, we will summarize the sources and bioavailability of IP6 and its potential neuroprotective roles in preventing or slowing down the progression of PD and AD.

[38yroldmale]

I know that it helps me. Not a huge difference but definitely noticeable. Both NAC and Inositol is being used in psychiatric conditions which to me is getting to the root cause rather than an SSRI that tricks your body. Try it, it’s cheap and helps mentally and the side effect is it could fight PD?