I’ve basically done this same study I’ve linked to in this post since the first of December. 50 mg of b2 every 8 hours and no red meat. The study is 30 mg dose but I can’t find it. My b2 was very low. The test was very expensive but worth it to know. However with no side effects and being very cheap, you could just try it without testing your levels. It took about 2 months to feel any difference. I feel a ton better and still feel I’m improving. Try it, unlike most other things I’ve tried, I’ve had no side effects.
I also believe Restore Gold has been very Beneficial. It’s ingredients, NAC, which increases your glutathione, Tauroursodeoxycholic acid (TUDCA), a sister to a pharmaceutical drug that has proven to help with PD and I believe slow progression and others helpful ingredients . I’ve had Parkinson’s for coming on five years. I stopped taking restore gold for about six months, six months ago. I progressed more in those six months than I had in the almost 4 years before that. I’ve been back on it for six months, and with the help of B2, my progression has stopped with a light regression symptoms on my affected side.
It’s gross but my second and third toes my affected side I have had athletes foot fungus that makes the toenail disgusting. I’ve read a book that It said that it’s very common for that to happen with Parkinson’s. My unaffected side toes started to cloud over like my affected side when I was off the restore gold for six months. During that time, my neurologist said that the Parkinson’s was moving over to the other side. Since being back on the restore gold , and doing the B2 protocol, the neurologist said that my Parkinson’s had disappeared from my good side . Also, my toenails have completely cleared up on the unaffected side and it’s starting to clear up on my affected side. I don’t know how you can believe it’s placebo affect. I’ve also started to take inositol that helps with OCD and has natural iron chelation properties that could be responsible for problems with PD. I’m guessing if you’re reading this, you probably have some OCD tendencies, which is very common with. Parkinson’s. I started taking in inositol for OCD about 4 months ago as well so maybe the improvement is a combination of the 2.(b2 and inositol) I hope my information might help someone else that’s struggling.
Fascinating. It never crossed my mind that OCD might be related to Parkinson's, but here it is: jnnp.bmj.com/content/70/3/394
Toenail fungus is not referred to as a Athlete's foot but rather it's called onychomycosis. It never crossed my mind that this could be related to Parkinson's either.
Have u seen a less descriptive, worthless study. 9 Patients?? Are you kidding me? It’s almost as if they wanted to disregard any effects of inositol?
I am almost fully Scandinavian. I know that it’s common for people of Scandinavian and northern European decent to have problems absorbing too much iron. I live in rural town that has a Scandinavian festival because so many of us are from there. There are also tons of people who have Parkinson’s, way more than average
Indeed it was a small study. There was a non-stat sig improvement in their measure of motor impairment, although placebo helped almost as much. It therefore falls short of proof that inositol could not help with Parkinson's. More importantly, however, it did not do any harm, and you are taking it for OCD, and there's at least one study showing that it helps with OCD.
A Parkinson's cluster in your town calls for investigation. It could be genetic, or environmental, or combination of the two.
If you want to lower iron accumulation, the best and the fastest way to accomplish this is through blood donation or therapeutic phlebotomy. Iron chelation depends on the form of inositol.
yes, I’ve read about the toenail fungus, as well. Here is a link to the free book regarding this (I don’t have the exact area in the book notes from the top of my head.. The eastern philosophy and parasympathetic emphasis on recovery is quite interesting, indeed. pdrecovery.org/wp-content/u...
hubby has fungal toenail too. He had a bad reaction to anti fungal years ago so stopped them. I wonder if it the fungus or the anti fungal drugs that link to PD?
He also had rosacea for years and we we got rid of that with gluten free diet, b5 , allimed and berberine. That stopped the smell too.
oh yes, OCD at our house! Hubby and 20 year old son definitely have it. The more anxious they get the worse it is. I think it is some kind of control method to soothe anxiety.
First I noticed it with hubby was decades ago when kids were small. He used to fold washing and toddler underpants into tiny little piles and have arranged in underwear drawer. Heaven help anyone who went into drawer and disturbed the arrangement! Yet he has no concept of cleaning anything, particularly the toilet!
Son has very strange ones like not finishing the last of anything. Opens new packets when there is still 20% left. And won’t use last 20% of toilet roll. Very tidy and particular. Very paranoid about people touching his stuff and germs from said people.
They both have to do a list of things before they can get started on anything and will delay starting to last minute which maximises stress!
I have been searching but I was unable to find any information about B2 / Riboflavin being an antifungal. Would you please share if you find any info about the same?
I was able to find Niacin / B3 / Nicotinic Acid being an antifungal here:
yes, I’m on Rytary. I’ve lowered my dose a couple of times and on the lowest dose they make. I have a very fast comt so the extended release works better for me
my hubby has a very fast dopamine beta hydroxylase but his COMT seems one of the only thing that is normal. Having said that they just put him on a COMT inhibitor to try and slow down his dopamine breakdown . He is feeling quite good at the moment as he often does once summer is over here.
I am now thoroughly confused. A whole book was written about b1 therapy. But you're talking about b2, yes? And someone here mentioned b5 as well. I don't have any toe onychmycosis .. but my toes on my affected side sure do curl. I'm not sure what to try anymore. Could use some guidance.
The great thing about b2 is the only side effects is yellow urine. B1 can have a worsening of symptoms at overdose. The study I sent a link to was easy, eliminating red meat and taking at least 30mg every 8 hrs. They had amazing results.
That’s regarding inositol, not b2. Methylation can be increased with methyl donor, that can make some people with MTHFR/fast comt feel worse and use up dopamine quickly.
MTHFR is related with the body’s ability to folate. It’s complicated but I cannot absorb folic acid, and the folate I can us is around 15% of a normal person. COMT is basically how quickly your body uses up neurotransmitters. My COMT is extremely fast. Stalevo is a form of levodopa that has a drug paired with it that slows down COMT.
I'm confused - which form of inositol do you take?
If you're taking inositol for OCD, then you're probably taking myoinositol, the most prevalent form. This form is not known to chelate iron. Such as this amazon.com/Jarrow-Formulas-...
To bind and chelate iron, you need IP5 or more commonly Inositol hexaphosphate (IP6), also known as phytic acid, which is known to also bind zinc and other minerals.
Also, I really wish folks would say up front whether they are on meds as well. I am doing my best to avoid taking the meds, and hoping I can find a set of supplements that will do the trick.
I read that main difference between riboflavin and riboflavin 5 phosphate is that riboflavin is the inactive form of vitamin B2, whereas riboflavin 5 phosphate is the active coenzyme form of vitamin B2.
Please Jay…be more mindful of the stuff you put up. Riboflavin (B2) in either form, taken orally is in no way associated with blindness.
You are referencing a drug. Here is the write up
Riboflavin 5-Phosphate eye drops is a photoenhancer used in combination with the KXL® System in corneal collagen cross-linking for the treatment of progressive keratoconus and corneal ectasia following refractive surgery…This medicine is to be given only by or under the supervision of your doctor.
Jay, they look pretty good but I’d want to be at least over 600 with B12, I prefer around 1000. Your b6 could go up a tad, but be very careful with b6. Can interfere with meds and can become toxic, (I did)
Thanks. I was worried about the B1 and B2 values, but I believe the reference range is based on normal RDA, and the high dose values would report beyond the reference range.
1. Way less stiff. Gait improvement (my worst symptom) more dexterity on PD side. My meds seem to last longer, I also lowered it from 3 times a day to 2 times a day
2. I started last part of November, so about 6 months
I started 30mg thrice a day 15 days ago. Have noticed better sleep. I was on Syndopa CR 250 twice a day. Have stopped the noon pill 3 days ago as I was feeling worsening of symptoms after taking the pill and feel better without it. Still taking the pill before bed
Currently:
8am: 1 cap methylated b complex containing 30mg b1 HCL & 28mg Riboflavin+5phosphate mix, 2x100mg b1 HCL and 1 magtein cap
I’m doing great. My 3rd toenail on my PD side has completely cleared up and my 2nd has about a 1/3 clear. I think EVERYONE who has PD should start taking B2. No side effects and very cheap! I’m taking about 1/2 the c/l I did before. I also discovered my liver was damaged and not working as well as it should. I’m detoxing my liver, limiting my sugar and drinking lots more water. I’ve been taking most of the top supplements that Dr Mischley studied. I’ve started one by one and saw benefits with almost all of them. Very little side effects.
This study is one of the most important things I’ve read on PD
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