ADHD, autism, schizophrenia, high IQ = greater risk for PD. PD process linked to Fibromyalgia. OCD links to PD

I have theorized that PD is related to many other neurological issues all having some of the same root causes that manifest in different ways and can lead to or coexist with PD.

So far my theory is looking to have some validity. I find this to be relevant because I also theorize that if I can determine what these diseases all have in common, I will be getting closer to understanding the root cause of PD.

Below are links to a some of what I have read so far. ADHD, autism, high IQ (gifted spectrum) and schizophrenia are all associated with greater risk for PD. The PD process has similarities and links to Fibromyalgia. OCD manifests due to a process that also occurs in PD. I theorize then that OCD behaviors are higher amongst prodromal PD populations.

Although I have yet to find anything substantiating this, I theorize that Auditory Processing disorder and Sensory Processing disorder are more prevalent in prodromal PD populations.

Personally, I have OCD, sensory processing issues, autistic traits & was labeled as “gifted” as a child.

OCD: I have hyper self discipline when I decide something is important, hyper sensitivity to immorality or what I perceive as immorality, etc etc.

Sensory & auditory processing: I also have sensory and auditory processing disorder meaning I get overwhelmed and hate very stimulating environments like concerts. (But I love intellectually rigorous opportunities, not sure if that’s related)

Autism: I have traits associated with autism but can “fake it” as far as being social but I find sarcasm to be deeply unpleasant and unkind. I think this is OCD coexisting with a little autism.

High IQ/ intellectually gifted: does not necessarily equate to academic or professional success as it’s a different but not necessarily better way of processing information. As a child I was “tested” for giftedness and labeled as such. My kids are “gifted” too. (It’s not something to boast about, being “gifted” can make life more challenging.)

I’m sharing all this in hopes others will self reflect and share if they have had any of the aforementioned neurological traits preceding or coexisting with PD.

I wish someone like Mischley would culminate info on this as it can help with identifying bio markers and help with deciphering root causes.

EDIT: This is not an article. It is just my research notes. Articles, are in links below, in my comments.

[Hidden]

ADHD linked to PD

pubmed.ncbi.nlm.nih.gov/335...

[Hidden]

Autism associated with increased risk for PD

jneurodevdisorders.biomedce...

[Hidden]

Parkinson’s linked to Fibromyalgia

hra.nhs.uk/planning-and-imp...

[Hidden]

Schizophrenia increases risk of PD. This is further proof that PD is about more than just dopamine and is associated with insufficient serotonin

sciencedaily.com/releases/2...

[Hidden]

OCD link to PD

jnnp.bmj.com/content/72/3/420

[Hidden]

Great summary of OCD symptoms which is good for self reflection

brightquest.com/obsessive-c...

[Hidden]

High IQ and greater risk for PD

scienceofparkinsons.com/202...

[Bolt_Upright]

I check the boxes too:

OCD: You never have to wonder if your car is locked if you get out of your car and I am around. I have pulled door knobs off of multiple doors making sure they were "really" locked.

Sensory & auditory processing: I can't have music playing if I am working. When driving the radio gets turned off if I am exiting a place or looking for a place. Radio is only for smooth sailing. I can't shop in a big box store if they are playing music.

Autism: I put the ass in Asperger's.

High IQ/ intellectually gifted: The lowest my IQ has ever tested was 136.

[Hidden in reply to Bolt_Upright]

Bolt! You just described me! 🤓

[BootsOn in reply to Hidden]

Oh heck, me too. 🥴

[Manypony in reply to BootsOn]

Me 3

[laglag]

Have you tried to get in touch with Dr Mischley? I bet she would love talking to you.

[SilentEchoes]

You got my attention!!! Off the cuff, my neuropsych evaluation report said above average intelligence for my level of education 🙄 - it's not my yardstick. I enjoy learning not the classroom. What we associate with autism is also associated with complex PTSD. I'm persnickety about things, don't think it rises to the level of OCD. Sometimes repetitive behaviors are stimming - l twiddle my thumbs. I've always been reserved and an observer. I'm also an empath. I attribute my coping mechanisms to childhood abuse and not being able to trust the adults in my life. The neuro-psychologist asked if I was sexually abused - I wasn't. It doesn't make the trauma any less damaging. I can be very social one on one.

Autism is basal ganglia dysfunction, so is PD. Basal ganglia pathology is also a feature of schizophrenia. In 2016 I had a Spect brain scan at CereScan. The radiology report said my scan showed a patchy diffuse toxic/hypoxic encephalopathic process. That's brain inflammation. I brought my Spect scan with me to the University of MN and the neurologists said it didn't mean anything. I also disclosed my poisoning and compared it to Gulf War Syndrome.

I had the DaTScan two months after the Spect and my hair fell out. The DaTScan showed abnormal brain atrophy. I realize now that the movement disorder specialist knew damn well I didn't have PD or MSA (my differential). I learned later that he and the neuropsychologist were trying to support a schizophrenia diagnosis with the DaTScan to discredit me, and couldn't because it was negative; so the @$$hole entered a somatoform disorder diagnosis into my EHR/MyChart, and flung the door wide open for other doctors to gaslight and abuse me.

In 2018 I went to the hospital for respiratory alkalosis caused by my bipap machine. The ER doc thought he'd have some fun at my expense and said I had anxiety and hyperventilated. Right, because it happened while I was asleep and using the bipap, and woke up unable to breathe. I asked for blood gasses. Then went to a different hospital to have the blood gasses tested again, it took months to semi recover from this episode. I was headed toward respiratory failure. I couldn't use the bibap anymore and struggled with worsening resperatory insufficiency for over a year. In 2019 I was diagnosed with MND by John Bach, it took almost 6 months to get someone to fill my prescription for the ventilator and provide RT. I was in real trouble, desatting to 69% and had central apnea events that were almost a minute (56s). This is definitely not anxiety.

Fast forward to 2020 and I decided to take advantage of the online opportunity to test for Fibromyalgia, a chronic pain syndrome. I'm not in pain (generally) but I checked a lot of the other boxes. It came back strongly positive 88/100. My insurance paid the full cost of the test. I didn't know at the time - that the test checks for anti-NMDA receptor antibodies, this is associated with virtually all neurodegenerative disorders, many cancers and limbic encephalitis (brain inflammation) linked to lymphoma 🤔

People who test positive are invited to enroll in a clinical trial that promises to cure FM.

We aren't being tested and we aren't being treated for a wide range of eminently treatable anitNMDA receptor antibody positive neurological conditions, with IVIg and plasmapheresis and NMDAr antagonist memantine. What if we went Joe Tippens on the medical system with the support of Dr. Mischley? 🤔

Who is Joe Tippens? Joe had advanced lung cancer and enrolled in a clinical trial at MD Anderson - while also secretly treating himself with an OTC dewormer. The efficacy of his protocol was undeniable, Joe was the only survivor. You can read about Joe Tippens here: mycancerstory.rocks/

Thanks CC ❤️

[Hidden in reply to SilentEchoes]

So much to dive in to in your comment! I will message as I unravel it.

[SilentEchoes in reply to Hidden]

❤️❤️

[AaronS]

Root cause of PD is being exposed/trapped in Fight or flight.PD Is basically about a out of whack stress response from our bodies. I thought it was dopeamenic however I'm now often saying to my wife that I'm actually better probably at least 40% of the time not taking my ldopa meds. Which proves In my case it's not a lack of dopamine. There are 3 well known/ hypothesised reasons for the start or reasons some one may get PD symptoms, Chemical exposure in fair amounts, heavy emotional exposure and the third was stealth viruses, like the ones that cause "medically/pharmacological quntreatable" bodily concerns such as chronic fatigue and thyroid malfunction.

We listen so much to not a healthcare system but a sickcare system. No one in this world even encourages you to do things that will boost and strengthen your immune response, case and point covid lockdowns, but you go with sad feelings over harder life situations and you will be given a wealth of medications, yet whilst it's harder but a better outcome mentally go to the gym and participate in a regular but enjoyable amount of exercise, and then explain how you feel.

I have actually taken a huge amount of information from all the people who claim to be cured of PD, and in general laughed about by the majority of people on this forum who obviously haven't cured their version of PD and just keep progressing all the meanwhile keep saving up for the big final treatment DBS.

I'm just presenting another thought process and back to my point about the 3 generally accepted environmental causes of PD what do the 3 have in common?

.......they all flag the fight or flight process within the body if exposed for to long to the particular item.

Look that up , take care Charlotte xx

[Hidden in reply to AaronS]

Yes yes yes!! “I have actually taken a huge amount of information from all the people who claim to be cured of PD”. Me too!!!

When someone on this forum refers to someone as a fraud, then I know they are worth reading about.

Example: John Gray, Fraud or Hero?

He has nothing to gain that would be of value to him by “coming out” as someone with PD who has reduced his progression to the point of it feeling like a cure.

But, he has a lot at stake by doing it. He is an extremely successful and wealthy author.

He has totally put his reputation at stake and I guarantee it is not for personal gain, it is because he is so darn happy he has found things that work for him that he wants to share it.

I personally knew him. He is from where I’m from. He was very well known and respected. To say he is a fraud because he excitedly talks about how he has stopped his PD progression and is a fraud because he is doing it for personal gains is literally stupid. A lot of product pushers are frauds. But selling products does not make you a fraud. I am absolutely certain with no doubt at all that John Gray values his credibility and reputation far more than any income he may or may not be making off of coming out as someone who has stopped their progression.

I don’t want to derail my own thread but I just had to comment on that aspect of your comment!!

[Manypony in reply to Hidden]

Any link to his information?

[Hidden in reply to Manypony]

I just started a new post about this subject and will add to it as time permits.

[JustJeff]

Thanks for this article sadly i can relate to most of it

[Gcf51]

For those that have taken Meds for Bipolar, OCD, etc. you have to question if the meds caused PD.

[Manypony]

Bingo! I got very autistic with PD. Been hyper vigilant my whole life. Gifted! Lol!yes, that too.

[SAGoodman]

Ccraspberry I am right there with you!! Been OCD my entire life, but if you call and ask me where something is at my house, I can guide you right to it! High IQ, never tested but in grade/ high school never studied or brought a book home, but got good enough grades to allow graduation a year early. Had to learn to study after going to college which was tough! 😂

Sensory, do not enjoy large crowds at all, and am uneasy in restaurants, but love a good one-on-one conversation.

One thing to add that you didn't meantion is trauma, as I races motorcycle off road for 26 years, and had many broken bones and head impacts (broke 3 helmets).

That is all I have for now 😁

[Hidden in reply to SAGoodman]

I think head trauma and PTSD deserve their own research and posts as they are so important. What I posted was confined to those things that are interrelated and manifest with little apparent outside force and all respond to lifestyle interventions similarly

[Kia17]

All the above diseases might have the same pathological root cause which is neurotoxicity (excitotoxicity) as a result of high level of excitatory neurotransmitter glutamate activity.

Dr. Kathleen Holton is one of the best scientists who has been working in this area.

american.edu/cas/health/nut...

youtu.be/Iy3JNtk18SU(Not working as expected?)

[Hidden in reply to Kia17]

Yes! It was researching glutamate Excitotoxicity that steered me towards this idea but I had not seen the video or heard of her. Thank you!

[Hidden in reply to Kia17]

Kia, listening to it now. Everyone needs to hear this! It deserves its own post!

[Kia17 in reply to Hidden]

I totally agree with you.

[Hidden in reply to Kia17]

Kia, at about 13 1/2 minutes they address that counteracting glutamate with GABA does not produce the desired result, quite the opposite. Which leaves me thinking that caution should be used with taking high doses of GABA producing supplements like melatonin. I have posted before about gluten increasing glutamate but I found a video last night that explains this better than what I have read. (I prefer to read but videos enable me to learn whilst busy)

youtu.be/VhFbgoW9TWo(Not working as expected?)

[Kia17 in reply to Hidden]

You are right. Because GABA is the end product of Glutamate, it doesn’t mean we can counteract Glutamate with GABA. In this case again Glutamate will rise to counter balance with GABA and that leads to more toxicity and degeneration.Another interesting thing is in some people who have gone through non-glutamate diet for sometime and then given glutamate containing foods they feel better which might explain that glutamate story is similar to keto diet and taking some time for the body to adapt to no- glutamate diet.

[Hidden in reply to Kia17]

“Glutamate will rise to counter balance with GABA”. Agreed as that is what I read and heard but it was before I knew about glutamate excitotoxicity so I did not appreciate the importance of this at the time. Those who are big supporters of and users of high doses of GABA producing supplements should know this. It reminds me of how too many antioxidants can actually increase ROS.

[Kia17 in reply to Hidden]

👍

[Hidden in reply to Kia17]

At approx 31 minutes they discuss how excess GABA increases glutamate. They are discussing it in the context of alcohol but like melatonin, alcohol increases GABA which is why the sedative effect. But then a response of excess glutamate can reduce REM sleep and cause insomnia. Common knowledge that Melatonin at low doses causes excess drowsiness due to excess GABA but in high doses it can actually cause insomnia.

This has happened to me.

youtu.be/BRlLSpIILTk(Not working as expected?)

[Kia17 in reply to Hidden]

Really interesting.

[Stillstandingstill]

Hi. I'm new on here and finding it fascinating to read everyone's posts. I was diagnosed with PD 2 years ago aged 50. My father has a lifelong history of OCD and clinical depression but no PD. I believe I suffered from ADHD as a child in which being a little girl, I suppressed the hyperactivity part to fit social norms. Looking back I've always struggled a bit socially.

[ion_ion]

I wish I had lower IQ!