N-Acetyl L-Leucine?

[reedboat2]

is anyone using this form of Acetyl Leucine, as opposed to Tanganil, which is the DL form?

Thanks- JG

[Lucas_s]

I don’t think it is available anywhere

[Flipper_B]

I bought it and will try after my Tanganil stock is depleted. Will take a while.

[Despe in reply to Flipper_B]

Nothing is available in France, Belgium or any country in Europe any longer. . .who knows what is going on???

[Flipper_B in reply to Despe]

I had a gut feeling of this coming and bought as much as I could in December. I have my theories. Will try to find out a bit more before I open my mouth.

[Despe in reply to Flipper_B]

Big pharma discovered Tanganil's therapeutic qualities and quickly acted accordingly!!! My niece works at the European Parliament in Belgium and visits France often. She looked for it everywhere, even for the generic, NOTHING! Her pharmacist in Belgium will keep an eye on it, and she will let her know when and where to find it again. SAD!🤨

[Flipper_B in reply to Despe]

AQNEURSA is the new N-acetyl-L-leucine available in the USA. It costs about 500 times Tanganil. I know what I would do if I worked as a lawyer at the company producing AQNEURSA. Letters threatening competitors to stop selling their stuff or there will be law suits? They have a 2 year exclusivity so probably we will have to wait until October 2026 before we can buy it again. Yes, Big Pharma protects their interests=money, rather than helping patients.

[Despe in reply to Flipper_B]

Long time to wait for its availability again!

[Flipper_B in reply to Despe]

Let’s hope my anticipations are wrong and see!

[Despe in reply to Flipper_B]

👍

[Flipper_B in reply to Despe]

I just checked all my stock, I bought as much as I could from everywhere. I still have almost 1 kg and if I take cures one month and then washout periods for 2 months it will last for two years and then hopefully it will be available again.

[Despe in reply to Flipper_B]

Lucky you.😀

[Rufous2 in reply to Flipper_B]

What makes you think it will be available again in two years? I believe most patents last much longer than that.

[Flipper_B in reply to Rufous2]

Because it probably can’t be patented, this stuff has been around for a long time. What I think they got is an exclusivity, which you can get for medication for very rare diseases in children, and that is the actual purpose of AQNeursa. An exclusivity can only be held for two years. But these are just assumptions, I hope someone who knows about these issues can correct me. If they got a patent they could sell it for other neurological disorders as well and make more money.

[Rufous2 in reply to Flipper_B]

But Aqneursa is acetyl-l-leucine and Tanganil is acetyl-dl-leucine. Are they, in a legal sense, considered to be the same substance? And does that somehow allow IntraBio to challenge Pierre Fabre's right to sell Tanganil, a substance they've been selling for decades? Wow.

[Rufous2 in reply to Flipper_B]

data.epo.org/publication-se...

[Flipper_B in reply to Rufous2]

That’s what I also wonder. Could Intrabio actually claim that Tanganil contains the L-enantiomer on a 50% level and thus cannot be sold? But this is just a patent application. Did they get a patent? In which countries? The same argument then could be taken by Fabre that the patent cannot be accepted because they already sell 50% of the stuff since 1957. Or perhaps Fabre doesn’t want to fight because it will be an expensive fight in courts and they probably do not make much money out of Tanganil? This is a very important issue that needs to be discussed. Millions of people who possibly could avoid PD but are not able now to get this medication are affected. A patent for medicine can be overthrown if the consequences are that people will die or suffer. Ok I know all this is based on a lot of assumptions from my side but hopefully someone will prove me completely wrong.

[Rufous2 in reply to Flipper_B]

AI says this; "Yes, IntraBio has patents on acetyl-leucine and its use in treating neurodegenerative diseases and lysosomal storage disorders.

Patents

EP3359146

A patent related to the use of acetyl-leucine in treating neurodegenerative diseases

EP3416631

A patent related to the use of acetyl-leucine in treating neurodegenerative diseases

EP3482754

A patent related to the use of acetyl-leucine in treating lysosomal storage disorders

USPTO10905670

A patent related to the use of acetyl-leucine in treating neurodegenerative diseases and lysosomal storage disorders

USPTO11400067

A patent related to the use of acetyl-leucine in treating neurodegenerative diseases and lysosomal storage disorders

WO2017182802

A patent related to the use of acetyl-leucine"

[Rufous2 in reply to Flipper_B]

A few years ago the  Natural Products Association brought a lawsuit against the FDA  for threatening to ban the use of N-acetyl-cysteine in over-the-counter products. The cases are a bit different, in that NAC had been being used in dietary supplements, whereas ADLL was available as an over-the-counter medication. Still, NAC is currently available, which makes me think it might be possible to fight the NALL patents (which it seems, are for all iterations of acetyl-leucine.)

supplysidesj.com/supplement...

[Flipper_B in reply to Rufous2]

Very interesting! But who is going to take the fight for NALL? And we still don’t know for sure if NADLL also is covered under this patent, that will probably also a matter for a court to decide.

[Flipper_B in reply to Flipper_B]

”…are for all iterations of acetylleucine”

But they couldn’t get a patent holding in court for NADLL, they can get it but it would be easy to fight in court for Fabre. I am afraid that Intrabio and Fabre could have made a deal and Intrabio could pay Fabre for the loss of Tanganil sales. Big Pharma….

[Rufous2 in reply to Flipper_B]

"But they couldn’t get a patent holding in court for NADLL"

Not sure that's true. The molecular formula for the two substances is the same. And the FDA has stopped importation of Tanganil to the US, presumably on the grounds that it's a recognized prescription med (Aqneursa.) That implies it sees them as equivalent.

At any rate, fighting this would take deep pockets So an inexpensive, safe and possibly effective treatment will be denied to hundreds of thousands of people who might benefit from it. Many could well die before double-blind studies are even begun.

[Flipper_B in reply to Rufous2]

If the patent holds it could in worst case mean a lot of people will probably be denied a drug to help them avoid PD. It is a serious matter indeed and something worth fighting for. I have an idea on how to do it but I am certain the Intrabio lawyers read here as well, so I will not reveal anything here.

[Sophia777]

I'm taking something similar: S-Acetyĺ L-Glutathione, along with Mucuna Pruriens Extract. Brand: Double Wood Supplements.

[gomelgo in reply to Sophia777]

And how is that going? Also could folks please describe the symptom relief they get from this tanganil?

[Leest2023]

You can buy N acetyl l leucine (as well as the dl form, so be careful when ordering)from a brand called Mark Nature. It's shipped directly from China as a bulk powder, so it's not 3rd party tested for purity. I just got some, but I'm a bit fearful to start taking it. Its been discussed on this forum extensively.

[Despe in reply to Leest2023]

Checked the site--not available.

[Despe]

Good to know but . . .quality?

[ForcedToJoinToRead]

Oh no. I cannot believe it is not available any more. That is very bad news.