tingling in hands

[saraoutwest]

I started taking homocysteine factors and b12 as per dr mishleys recommendation (I had low b12 on labs) started a week ago now feeling tingling in hands and fingers and a little in my feet. Should I be concerned?

[park_bear]

Yes, that is reason for concern. It is neuropathy typically caused by B6 depletion as a result of levodopa medication. See my post here for starters and then look at my other posts that I referenced there: healthunlocked.com/cure-par...

[Esperanto in reply to park_bear]

There will certainly be no B6 deficiency, different as you say PB. If we are indeed talking about 2 supplements from the brand Pure, then you get a daily dose of 500 + 200 micrograms of B12 per serving. That is an incredibly high amount, almost 30,000% (!!!) of the daily required intake. Add to that the excessive dosage of 25 mg of B6 (1,471%), although it is the relatively safe P5P form, I'm afraid that even in such a short time, there may already be signs of peripheral neuropathy starting... The advice is to stop taking the supplements and get tested first!

[park_bear in reply to Esperanto]

I do agree if the tingling started after she started supplementing B6, that would be an indication of vitamin B6 toxicity. B2 deficiency is common in Parkinson's patients and can cause B6 toxicity as I set forth in this post: healthunlocked.com/cure-par... Anyone supplementing B6 should also supplement B2, which is non-toxic even in high doses.

[saraoutwest]

good to know. It definitely started AFTER I started taking the PURE brand she recommended. I’ll stop for abit and continue with the b12 only in a week or so

[JCRO in reply to saraoutwest]

You should ask her directly. A quick email to her team normally gets a fairly prompt response.

[saraoutwest in reply to JCRO]

thanks

[Bolt_Upright]

"Many people are not aware that vitamin B6 can cause peripheral neuropathy, which results in tingling, burning or numbness usually in the hands and feet. Taking vitamin B6 even at low doses can cause peripheral neuropathy but people are more likely to get it if they are taking more than one supplement."

I remember back in the 80's B6 supplementation was all the rage and some people thought they had MS and it turned out to be the B6.

[Esperanto]

Most likely this can be a B2 deficiency, as park_bear supposes, or another imbalance that has occurred. For therapeutic purposes, as suggested by Dr. Mischley, individual B-vitamins can be taken in higher doses, although I would avoid that with B6 also with the safe esteemed P5P. 25mg is just too much. However, it is always important to use a multi with B-vitamins or a vitamin B-complex alongside, as B-vitamins work together extensively. Preferably, take B-vitamins in in their active, co-enzymatic form, as they are often found in food. In any case, the imbalance that has now occurred should be corrected as soon as possible. Discuss this and the neuropathic symptoms that have arisen as soon as possible with Dr. Mischley.

[bookish]

I would agree that you should go back to ask the doctor, but bear in mind that this may be reversing out as a result of getting the much needed B vitamins and starting to heal. How low were you ? 700 mcg is not a high dose of oral B12 (I take more than 10 times that, although I didn't start at that dose). Did she also test the B6? Mine was low so I increased my dose (I also take the rest of the Bs and don't have PD....). It could also be that you are reacting to a filler or to the vitamer of B12.

[saraoutwest in reply to bookish]

my b12 was 220. I didn’t have b6 checked

[bookish in reply to saraoutwest]

Pity about the B6. From that result I'm assuming it was a serum B12 rather than an active (holotc) B12. Low, but wouldn't have been treated as such everywhere. Testing is so hit and miss, with many flaws and potential for missing a deficiency, especially at cellular level. Depending on your symptoms, it still seems possible that it is repairing nerves that you are feeling. But stopping the B complex as you suggest, checking with Dr Mischley and reintroducing the B12 should pin that down for you. Whether your serum folate was low or high (without supplementation) might give you some clues too, as to methylation function. Did she check homocysteine or MMA, or antibodies at all? Best wishes

[rebtar in reply to saraoutwest]

Ask Dr mischley. She usually does a hair test as well as serum to look for b12 deficiency. Low cobalt, I think, in hair indicates low b12.

[chartist]

Too much or too little B6 can result in PN. Your product, Homocysteine Factors has 25 mg of B6, which is about 19 times more than the daily allowance. The daily allowance is 1.3 mg. Did Dr. Mischley check your B6 level?

Art

[saraoutwest in reply to chartist]

I’m not a patient of Dr Mishleys. I have only watched her videos and gone by her recommendations on them. Since I stopped the homocysteine factors the tingling has stopped.

[chartist in reply to saraoutwest]

Oh, sorry, my misunderstanding. Your results suggest you may have an adequate B6 level and that addition of B6 in the supplement may have been too much.

That supplement should be quite useful for lowering the inflammatory homocysteine, which is elevated in PD and is a driver of the disease and disease progression, so I see why she recommends it, but knowing your B6 and B12 levels first would be important when using it.

Art

[LAJ12345]

are you taking magnesium? That can also be short. If you take a supplement of something you are short of you might uncover another deficiency once the original one comes right