Patent: Levodopa fractionated dose composition and use

patents.google.com/patent/U...

There is provided a convenient new treatment of Parkinson disease by a frequent administration of optimal levodopa doses mimicking a continuous intravenous or infusion treatment, thus mitigating motor complications; and a new carbidopa/levodopa pharmaceutical unit form providing said new treatment.

[Juliegrace]

Color me skeptical.

[Gioc]

It is possible also think of an application on smartwatch that would promptly detect the first motor signals at the end of the dose and warn that the time o f the next dose . An advanced reminder for pills.

[johntPM]

Gioc's suggestion of a smartwatch app to measure for the times to dose is a good one. But this is what dynamic dosing (edit: originally "programming") does, albeit subjectively: dose when you first notice the very first symptoms of going off. Then, if you time it right, as the first pill runs out the second pill will take over.

Interestingly, the patent states: "Generally, LD doses in the 75 to 125 mg range given every 2 hours (8-9 times over 16 hours) provide the best results, although wide inter- and intra-patient variability occurs."

I don't understand whether this patent is simply a set of scores making it easier to break a pill in pieces. Or whether it actually controls the absorption of the pill into the gut.

John

[Gioc in reply to johntPM]

John,

I also don't quite understand how it works.

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My point was not related to measuring the time between doses, but to the fact that the latest smartphones and smartwatches have sensors that are able to understand if you walk normally or asymmetrically and are easily wearable throughout the day. The asymmetrical walk is thus described by the health app of my smartphone: “

Asymmetrical walk: to know more

When the walking pattern is regular, the duration of the steps taken with each foot is very similar. Walking is defined as asymmetrical when the percentage of time required to step with one foot is greater or less than that of the other foot.

So the lower this percentage is, the more normal the walking pattern will be.

Irregular movements, such as lameness, may indicate the presence of a disease, …”. This is very similar to a unilateral PD symptom, it is precisely detected by a smarthwatch and could indicate an off time start and with a dedicated application warn the user. This is just my guess, but someone more experienced than me could give more precise indications on the possibility of having a wearable tool that tells us when to take a small dose of ldopa based on body movement.

Grafico

[KemptonD]

Through "Fractionization" - "a novel, multiscored, bilayered carbidopa 25 mg/levodopa 100 mg pharmaceutical unit form that enables precise dose fractionation to delay and even avoid the onset of motor response complications" - I was advised to use a pill cutter. I use the timer on my old fitbit watch. It's become a bit wonky in measuring my steps, but it keeps time. I am none the less cutting halves in to quarters in an effort to avoid Scylla and Charybdis states of Dyskinesia and Bradykinesia

[Hidden]

You may consider checking the inactive ingredients used. Some of them are light and moisture sensitive and turn to powder when cut. The powder may be more irritating than the tablet. Just noticed that the information about food interactions advise acidic foods may affect absorption too.