Maximum dose of levodopa

[aatje]

Can someone tell me the maximum dose of levodopa/madopar per ingestion?

And what is the maximum dose of levodopa from mucuna?

Or doesn't that make a difference?

[jeffreyn]

I feel reluctant to answer the questions, without having some context.

HU is not Google, you know.

[aatje in reply to jeffreyn]

I can imagine your feelings. My english is not so good but I make an effort.

I am trying to optimize my medication because of annoying offs. I think my neurologist advises too much madopar and mucuna. That is why I am now trying it myself. Mid-September by phone consultation with parkinsonian nurse.

[jeffreyn in reply to aatje]

Thanks for the context. It does help (a little).

You seem to be saying that you think that the neuro has overdosed you on madopar/mucuna, and that this is causing/worsening your off periods. Have I understood that correctly?

This seems strange, as my experience is that such overdosing would more likely cause dyskinesia rather than worsening of off periods.

Anyway, your original questions (and your thoughts regarding your madopar/mucuna dosages) are good things to bring up during your consultation with the Parkinson's nurse next week.

PS: I note from your past threads/posts/comments that you have considerable experience with these medications. About 18 months ago you wrote about taking madopar (levodopa/benserazide), mucuna (15% levodopa), and lodosyn (carbidopa) ALL AT THE SAME TIME. I just can't imagine your neuro prescribing that!

[aatje in reply to jeffreyn]

Believe it or don't believe it.

My dose is 1.5 madopar (100 mg Levodopa, 37.5 mg benzera) and 2 x mucuna (120 mg) levodopa. Four times a day. I also take 2 x 2 mucuna with 1 carbidopa (25 mg). And for the night 2 madopar with delayed release.

[jeffreyn in reply to aatje]

Did the neuro prescribe all that, or did you prescribe some of it?

[aatje in reply to jeffreyn]

Yes, the neuro

[jeffreyn in reply to aatje]

In that case I can't help you much, because I have no experience with mucuna. Maybe someone else who uses both Madopar/Sinemet and mucuna can advise. You may need to start a new thread though (and put in a link to this thread), as most people will probably have stopped looking at this thread by now.

Regarding Madopar, in my copy of the Madopar PI document (i.e. Prescribing Information), Roche describe a process for arriving at the correct dosage of levodopa. If I've understood it correctly, they say to keep increasing the dose in small steps until either the motor symptoms disappear, or dyskinesia appears. If it's the latter then back off a little.

This was basically the process that my neuro followed. I don't understand why your neuro put you on to the combination you describe.

[aatje in reply to jeffreyn]

Because of the off's. I seem to be a difficult case.

Thank you for your replies.

[WinnieThePoo]

Levodopa/madopar - if you are taking levodopa in the form of the drug madopar, then it is in combination with Benserazide which is a peripherally acting DOPA decarboxylase inhibitor, which is unable to cross the blood–brain barrier.

In simple terms, on average roughly 5 times as much levodopa from Madopar will make it to your brain as would be the case with just levodopa from mucuna

So no, not the same.

[condor39]

i am n a high dose of Madopar 25100, under supervision. of a Movement disorder Cliinc, I have earth slowly increased to 3 caps every three hours.\.I total 18 caps away. ,

I have no side effects, and take no supplements. I see no reason to try Mucina ??

* I wrtote Madopar, but I anode taking the Acadian version, called Prolopa.

John