[b]Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients[/b] 2018

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Vinpocetine regulates levels of circulating TLRs in Parkinson's disease patients 2018 sci-hub.se/10.1007/s10072-0...

I get 30 mg capsules from Swanson and take one a day with food.

Per this article: nootropicsexpert.com/vinpoc...

Vinpocetine helps:

• Cerebral Circulation. Vinpocetine helps boost blood flow to and within the brain. Improving the flow of oxygen and glucose that feed ATP to power brain cells. Improving alertness, cognition, concentration, memory and mood.

• Neuroprotectant. Vinpocetine blocks the accumulation of sodium in neurons, reduces the toxic effects of oxidative stress, inhibits the enzyme PDE1 and boosting blood flow, scavenges free radicals, and protects neurons from glutamate and NMDA toxicity.

• Neuroplasticity. Vinpocetine inhibits the enzyme PDE1 which can increase cAMP and cGMP. These cyclic nucleotides in turn activate a series of kinases that phosphorylate the transcription factors cAMP response element binding protein (CREB) and serum response factor (SRF), leading to the expression of plasticity-related genes.[iii] Boosting neuroplasticity enhances cognition and memory.

Special Precautions and Warnings: webmd.com/vitamins/ai/ingre...

• Pregnancy: Vinpocetine is possibly unsafe when used during pregnancy or by those who may become pregnant. Vinpocetine might increase the risk of miscarriage and might cause harm to the fetus. Avoid using.

• Breast-feeding: There isn't enough reliable information to know if vinpocetine is safe to use when breast-feeding. Stay on the safe side and avoid use.

• Bleeding disorders: Vinpocetine might increase the risk of bleeding. Use cautiously if you have a bleeding disorder.

• Weakened immune system: Vinpocetine might weaken the immune system in some people. This might reduce the body's ability to fight infections. If you already have a weakened immune system, check with your healthcare provider before using vinpocetine.

• Surgery: Vinpocetine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using vinpocetine at least 2 weeks before you are scheduled for surgery.

[Sydney75]

The TRC database lists Vinpocetine as a synthetic derivative of the periwinkle plant. Vinpocetine is a synthetic derivative of apovincamine, a compound found in the periwinkle plant, Vinca minor. It is also called ethyl apovincaminate or 14-ethoxycarbonyl-(3alpha,16alpha-ethyl)-14,15-eburnamine (68731). Is the French Pine Bark similar and natural?

While the data base listed many positive mechanisms of action pharmacologically it also listed negative side effects in addition to pregnancy complications and bleeding. Be careful if you have any heart issues, high PB, or arrhythmias. Other side effects include anxiety, gastric upset and sleep issues.

As with many supplements I guess it is best to start with lower dose and slowly increase to see how your body tolerates it. Sleep is so important in PD.

My HWP movement neuro explained that during sleep our bodies are in a type of paralysis and we make most of our dopamine at night. The restlessness of PD sleep reduces the production dopamine. He suggested we try melatonin again at lower does (because of RLS) as it it beneficial to many PD patients.

-Syd