Alpha Lipoic Acid for degenerative disease - Cure Parkinson's

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Alpha Lipoic Acid for degenerative disease

TL500•

1 year ago•25 Replies

youtu.be/6sXT6Hnt3Bc

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TL500

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Lipoic acid

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Bolt_Upright1 year ago

Interesting. Alpha-Lipoic Acid Mediates Clearance of Iron Accumulation by Regulating Iron Metabolism in a Parkinson’s Disease Model Induced by 6-OHDA 2020 ncbi.nlm.nih.gov/pmc/articl...

Conclusion

In summary, ALA displays protective effects against the damage induced by 6-OHDA in PD models, and its neuroprotective mechanism might be associated with improvement of oxidative stress and iron metabolism levels. Increased stress resulting from ROS production is one of the proposed mechanisms for the death of dopaminergic neurons in PD. In addition, iron metabolism dysfunction plays a key role in PD. Hence, ALA has a therapeutic potential for the treatment of PD.

ddmagee1 in reply to Bolt_Upright1 year ago

What if a PWP has to take iron for anaemia? Should Alpha-Lipoic Acid be taken by a person with anaemia, who supplements with iron?

Bolt_Upright in reply to ddmagee11 year ago

I'm sorry, I have no idea. I am not a proponent of ALA. I don't use it and don't plan on trying it.

ddmagee1 in reply to Bolt_Upright1 year ago

Thanks for your reply!

Bolt_Upright1 year ago

Per the video the dosage is between 600 and 5200 mg. You can get 60 100 mg capsules for about $21. That would put your costs to between $63 to around $600 a month. And there are side effects. Still interesting.

TL500 in reply to Bolt_Upright1 year ago

5200mg sounds a lot. Have you tried ALA?

Bolt_Upright in reply to TL5001 year ago

I have not tried it.

xy-zt in reply to Bolt_Upright1 year ago

I have read a couple of reports (do not have the links, sorry) that ALA slows the conversion of T4 to T3. Need to avoid that.

TL500 in reply to xy-zt1 year ago

What does that mean?

xy-zt in reply to TL5001 year ago

T4 is the storage thyroid hormone which converts (or should convert) to the active thyroid hormone T3 which is necessary for energy and well being.

TL500 in reply to xy-zt1 year ago

So does that mean a person with overactive thyroid (hyperthyroidism) should not take Alpha Lipoic Acid?

xy-zt in reply to TL5001 year ago

This is not medical advice, but I would avoid it.

chartist1 year ago

I have used ALA in the past, but have run into gastrointestinal issues above 1200 mg /day whereas , NAC, another potent antioxidant, I ran into gastro issues above 1800 mg/day. High dose melatonin has similar potent antioxidant effects to both ALA and NAC and it also has iron and heavy metal protective effects among a multitude of other PD protective effects.

Art

TL500 in reply to chartist1 year ago

Is melatonin for sleep? I can't remember clearly but seems somewhere I read about it there was some side effects?

chartist in reply to TL5001 year ago

Yes, in general, melatonin is thought of as an over the counter sleep aid and like anything else it does have some side effects with a main one being next day tiredness in some people. Not everyone experiences that effect. I am one who does not experience side effects from melatonin and have taken it at high dose for many years based on many studies and benefits which I have written about at length on this forum.

Art

TL500 in reply to chartist1 year ago

Can I have your link please, thanks

chartist in reply to TL5001 year ago

Link to what?

Art

TL500 in reply to chartist1 year ago

Benefits of melatonin that you have written on this forum.

chartist in reply to TL5001 year ago

Here is a partial list of what I have written about melatonin on this forum for PD or related to PD :

healthunlocked.com/cure-par...

There is more, but those posts combined melatonin with other supplements or I wrote them somewhere else.

Art

TL500 in reply to chartist1 year ago

Thanks Art

TL500 in reply to chartist1 year ago

Did ALA, NAC help you?

chartist in reply to TL5001 year ago

Not in a noticeable way, but then antioxidants in general seem to work quietly in the background to neutralize free radicals of multiple types. I would say they mainly help things to run smoothly in the body, so their effects are not always noticeable. I think the problems start to arise when a potent antioxidant like melatonin declines with age and then age related diseases like CVD, PD and AD start to increase and progress more rapidly. The decline of melatonin seems to become more noticeable around the ages of 45 to 50 years of age, though I think the negative effects of declining melatonin production start to show their appearance before then. Melatonin is produced in the pineal gland in the brain, the gut and every cell in the body, among other places that have not all been discovered yet.

Art

TL500 in reply to chartist1 year ago

I think maybe that is how I feel about ALA too, sometimes seems to see help sometimes not sure.