Honey for parkinson disease

[Farooqji]

Honey contains a variety of antioxidants in the form of flavonoids and phenolic acids, which can potentially reduce oxidative stress and repair the damage caused by it. Honey, along with other apitherapeutic products, has been reported to inhibit the activity of monoamine oxidase (MAO), which is involved in reducing the free radical scavenging activity and causing oxidative damage in neurodegenerative disorders such as Parkinson’s disease [212]. Recently a study by Topal et al. reported that Parkinson’s patients can make use of only pollen and honey produced by those bees that feed on flowers of Vicia faba L. as a treatment for Parkinson’s disease. This kind of honey contains a considerable percentage of L-DOPA, a commonly employed drug against Parkinson’s [213]. In conjunction with these studies, the polyphenols present in honey are also well studied individually for their use against neurodegenerative diseases

ncbi.nlm.nih.gov/pmc/articl...

[Smittybear7]

Very interesting! I wonder if Manuka Honey would be beneficial .It is from New Zealand

[Bolt_Upright]

This is about Royal Jelly (which is expensive and suspect) so I just substitute bee polen and raw honey:

Apitherapy for Parkinson’s Disease: A Focus on the Effects of Propolis and Royal Jelly - 2020 hindawi.com/journals/omcl/2..."6.1. Bee Products Protect Neurons against Oxidative Stress

Antioxidants protect neurons against neurotoxins by inhibiting the generation of free radicals. Several lines of evidence denote that flavonoids in propolis and derivatives of RJ lipids demonstrate neuroprotective effects in dopaminergic neurons, to a great extent, through modulation of oxidative stress. CAPE blocked the production of O2− and peroxynitrite in the brain of MPTP-intoxicated mice and inhibited the activity of the prooxidant iNOS in rotenone-induced mouse model of PD [44, 84].

6.2. Bee Products Protect Neurons against Neuroinflammation

Research shows that both central and local inflammation, which involves CD4 T cell infiltration and activation of CD11b+microglia/macrophages, play a key role in neuron loss in PD. Chronic activation of these cells is associated with morphological and functional alterations that promote excessive production of ROS [44, 87].

Research shows that bee products such as RJ display immunomodulatory and anti-inflammatory functions under conditions of neuroinflammation via activation of NRF2 [13]. In addition to being a master pathway that stimulates the release of antioxidants, NRF2 plays a central role in the suppression of inflammatory responses directly through downregulation of the transcription of proinflammatory cytokines such as IL-6 and IL-1β [92]. Moreover, redox control (expression of antioxidant genes such as HO-1) is another mechanism through which RJ might silence neuroinflammation [13]. HO-1 is a main cytoprotective agent not only against oxidative stress but also against inflammation.

6.4. Maintaining Brain Levels of Dopamine

Dopamine is the main neuroactive substance involved in PD [31]. Current PD treatments are based on dopamine replacement [44]. Active compounds in propolis increased dopamine levels in the SNC of experimental models of PD.

6.5. Enhancement of the Production of Neurotrophins in the Brain

Neuronal adversities such as chronic oxidative stress, neuroinflammation, and excitotoxicity are key contributors to progressive neurotoxicity and neurodegeneration. Neurotrophins are compounds that are essential for the survival of specific neurochemical phenotype classes of neurons [42].

6.6. Restoration of Normal Brain Structure

PD involves morphological alterations in different parts of the brain, including reduced volumes of the caudate nucleus, thalamus, and white matter, as well as atrophy of the basal ganglia, contraction in the left cerebellum, decreased gray matter in the right quadrangular lobe, reduced fractional anisotropy, neuromelanin pigmentation, neuronal loss within the SNC, and increased mean and radial diffusivity within the SNC and globus pallidus [108]. Experimental models indicate that RJ induces structural and symptomatic improvements in PD mice by protecting against the histomorphometrical dysfunctions caused by the disease. The effect of RJ on the integrity of brain structure is attributed to its antioxidant, anti-inflammatory, and antiapoptotic effects, which all lower the loss of dopaminergic and cholinergic neurons [99, 109]. The effect of propolis on brain structure was evaluated in 6-OHDA-challenged rats. Compared with the sham and placebo (water) groups, propolis significantly reduced striatal fiber degeneration [83]. However, the effect of active compounds in propolis on anatomical structures in the brain needs to be explored in future studies."

I have raw honey with 2.5 grams of Nigella Sativa powder every day,

[marimar378 in reply to Bolt_Upright]

Is Nigella Sativa powder the same as black seed oil ?

[Bolt_Upright in reply to marimar378]

Nigella Sativa is used to make black seed oil. I think you only need half as much oil but it costs more and tastes bad. I have found a number of studies that use powder instead of oil.

[marimar378 in reply to Bolt_Upright]

Thank you

[Little_apple in reply to Bolt_Upright]

what Nigella Sativa powder do you use? I have it in a liquid / oil form. It’s hard to get down bc it is so strong.

[Bolt_Upright in reply to Little_apple]

Terrasoul Superfoods Organic Black Cumin Seeds (Nigella Sativa), 1 Lb - Digestive Health | Immunity amazon.com/gp/product/B072F...

Grind it into powder with a coffee grinder. I use a little under a teaspoon of powder (1 TSP = 2.5 grams.) with raw honey.

[LAJ12345]

be careful of propalis and royal jelly at first try. My sister had a bad allergic reaction to it which nearly blocked her airways the second time she tried it.

[Larochka]

yes it is

[beehive23]

i eat comb honey and buy my royal jelly through places in san fran china town it is pretty cost effective...always test taste honey that is not local to where you live...hang tough

[beehive23]

Here is 3 months worth of royal jelly about 10$ a month. Hang tough....

Royal Jelly.

[Artarnold]

Thank you for this. I have tremor dominant parkinsons which is a pain as I am a professional artist. Although 74 next month, I would love to continue painting but it's impossible. I switched from Sinemet to Macuna as the medical people kept increasing my dose as it progressed but I was vomiting and had a kind of lock jaw. I was told to put up with it as its a known side effect. Am about to try sublingual B1 when it arrives. Tried the oral high dose but reacted to that. Anything new gives hope. Will look into this. Thank you.

[PDGal4]

This is most interesting as I've never liked honey but in the last 5 years or so I have been craving it and put 1-2 heaping teaspoons in my tea daily. I use local honey. Reinforces for me being tuned into and listening to your body.