Yes, PD definitely seems to be one of those diseases that just keeps on giving and giving, and not in a good way! This article link explains how PwP may be at increased risk for Leukemia by 10 times and Colorectal Cancer by 2 times if they happen to have a specific gene mutation in the LRRK2 gene.
>>> ' The pooled analysis revealed that individuals with LRRK2 G2019S were 9.84 times more likely to develop leukemia, and 2.34 times more likely to develop colon cancer, in comparison with idiopathic Parkinson’s patients. ' <<<
In the following abstract link, which is a review of studies regarding Melatonin and Leukemia, it is shown that melatonin has multiple activities that would work against Leukemia :
In the following study, it was suggested that melatonin has anti Colorectal Cancer effects via multiple pathways and effects including induction of autophagy.
Given the fact that it is well established that melatonin production declines with age and even further decline due to PD, it may not be a bad idea to consider the results of the 10 mg/day of melatonin in PwP study that showed positive effects in terms of positive effects on non motor symptoms in PwP.
' Genetically, mutations of the leucine-rich repeat kinase 2 (LRRK2) gene associated with sleep disorders and PD were significantly decreased when melatonin was administered (Sun et al., 2016)'.
It seems like melatonin, which is naturally produced in humans, animals and plants may be a supplement that just keeps on giving and giving, but in a good way of course!
Art
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chartist
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A study on MwP (Mice with Parkinson’s) concludes that: « prolonged, effective use of L-dopa in PD with lesser side effects could be achieved by treating with 60% lower doses of L-Dopa along with Melatonin » (Naskar et al, 2015).
It makes so much sense when you consider all of the many healthful things that melatonin does in PwP to fight all of the ill effects in the body brought about by PD.
That's great about melatonin. But how do folks take such, what appears to me, to be such a high dose? I can't get past 1 or 2 mgs LOL. I sleep and sleep in the a.m., then have a hangover. If I go higher, I talk a lot in my sleep. Even I can hear me :)! But is there a way to try more without going under for days? It's not like I sleep that well without it. I'm sorry -- not to put you on the spot. Just wondering if I was missing some info.
Anything past 3 mg made me nauseated the next morning, lasting hours. The highest dose I tried, 9 mg, made me feel awful and non-functional the whole next day. I also want to know the secret to tolerating higher doses. A slower, more gradual increase? Something else?
From what I have seen, there are three ways to get melatonin without the hangover for those who do get the hangover. The first way is to take melatonin by injection directly into the blood. The second is to take melatonin by suppository and the third is to increase your gut content of short chain fatty acids (SCFAs) which in turn increases melatonin and melatonin receptors in the gut. Melatonin produced in the gut never causes drowsiness at any time and is very healthful to the whole body.
I don't, because melatonin is considered both water and lipid soluble which is supposedly why it can easily pass through tissues and cells throughout the body.
La melatonina sembra essere un modo per aumentare gli SCFA. Un altro modo per aumentare gli SCFA è il consumo di fibre. È anche possibile assumere per via orale un SCFA specifico, come il butirrato, disponibile come integratore. Anche alcuni prebiotici sono in grado di aumentare i livelli di SCFA. Esistono anche alcuni batteri in grado di aumentare gli SCFA, ma per trovarli è necessaria una piccola ricerca.
Melatonin seems to be one way to increase SCFAs. Another way to increase SCFAs is by consuming fiber. You can also take a specific SCFA orally, such as butyrate which is available as a supplement. Certain prebiotics are also able to increase SCFA levels. There are also certain bacteria that can increase SCFAs, but that requires a little research in order to find them.
Grazie, quando parli di probiotici, a quali ti riferisci? Ho fatto fare a mio marito un ciclo completo di Bromatech....Enterelle, Bifiselle, Ramnoselle, poi Serobioma...ma per la verità non ho visto grandi risultati. Il butirrato, invece, non lo abbiamo ancora provato.
In realtà, non ho parlato di probiotici, ma di prebiotici, che non sono la stessa cosa. Dovrà leggere i prebiotici per farsi un'idea di quale sia il più adatto a lei. Anche alcuni alimenti hanno attività prebiotiche. Ecco un link con alcuni di questi alimenti:
Actually, I didn't mention probiotics, I mentioned prebiotics which are not the same. You will have to read about prebiotics to get an idea of which one would be most appropriate for you. Certain foods also have prebiotic activities. Here is a link to some of those foods :
May I ask Art what dose would you optimally take I’d say you were are 46 year old female? I’ve read that it’s not addictive but I continue to have reservations about a high dose which is possibly my irrational PD paranoia. I’m presently taking 25mg since reading the info you have shared.
I have been endeavoring to better understand vitamin D. Have not yet gotten very far but now realize it is not truly a vitamin but hormone (?) much like our dear friend melatonin.
It is very difficult to overtake D3. The info on its immune benefits are abundant but I wonder about its affect on the brain?
If anyone interested in having his/her pineal gland active to produce enough melatonin naturally , there are specific types of meditation to achieve that goal.
It not only activate your pineal gland but increase the BDNF and Endocannabinoids.
The meditation name is Shambhavi Mahamudra and taught by Sadguru.
The joys of doing this meditation cannot be described in words.
>>> ' Overall, these findings provide evidence that melatonin suppresses metastasis in colon cancer cells via inhibition of TMPRSS4 mediated EMT. ' <<<
I'm looking at the references page you linked to, but I am not sure which reference you are pointing at. Can you give me the number for the reference you are pointing out? They are numbered 1 up to 1125.
This new study (Aug. 2021) suggests that melatonin and hyperbaric oxygen(HBO) both work against colorectal cancer through multiple mechanisms and pathways. In my opinion, they are likely to be beneficial in some other forms of cancer also and in some other disease states.
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