Am I Taking the Wrong Vitamin B12? Adenosylcobalamin (AdoCbl) vs Methylcobalamin (MeCbl)

[Bolt_Upright]

Thanks to Gigi216 for sharing a link to this document: Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection 2019 ncbi.nlm.nih.gov/pmc/articl...

I noticed they were using AdoCbl, so I got my bottle and found I had MeCbl.

They did test with other forms of B12, and the other forms had some benefits, but in the end they reached this conclusion:

"Interestingly, we found that only AdoCbl, but not the other forms of vitamin B12, exhibited inhibition of LRRK2-G2019S autophosphorylation in MEF cells with an IC50 of ~10 µM, similar to that measured in vitro (Fig. 1f–g). We observed a similar inhibition profile for the different forms of vitamin B12 in macrophages derived from the LRRK2-G2019S transgenic mice (Supplementary information, Fig. S2d). The lack of inhibition displayed by CNCbl, HOCbl, or MeCbl is not understood at present, but one possibility is that differences in cellular uptake, localization and metabolism in the cells may affect their efficacy compared to AdoCbl. Because AdoCbl showed the greatest potential for LRRK2 inhibition in cultured cells, we focused our efforts on this physiological form of vitamin B12."

Do I need to upgrade my B12?

[Gigi216]

Yes! I take methylcobalamin too, I just ordered some of the other

[Smittybear7 in reply to Gigi216]

How much do you take and how often?

[Gigi216 in reply to Smittybear7]

Well most days I take 2000 mcg of methylcobalamin and now when I get AdoCbl I’m sure I’ll take the same 2000 mcg per day

[park_bear]

I take AdoCbl.

[Gcf51]

I came up with just a few choices searching for AdoCbl. Adenosylcobalamin came up with more choices.

[Smittybear7]

That form also comes in a sublingual form.

[LAJ12345]

veganhealth.org/vitamin-b12...

[gaga1958]

how about taking both forms?

[Gcf51 in reply to gaga1958]

There are supplements that contain both. Methylcobalamin focuses on lowering homocysteine and Adenosylcobalamin on energy & mitochondria. differencebetween.com/what-...

[gaga1958 in reply to Gcf51]

I definitely need both then.

[Gcf51 in reply to gaga1958]

If homocysteine is a problem - yes. But I am sure the other would also help with homocysteine too.

[Missy0202]

I take Adenosylcobalamin

[Gcf51]

"Additionally, this indicates that the methylcobalamin was converted to adenosylcobalamin for use in the MMA pathway." veganhealth.org/vitamin-b12...

[Zardoz]

KAL makes a sublingual B-12 supplement which has 1000mcg of methylcobalamin and 1000mcg of adenosylcobalamin.

[Bolt_Upright in reply to Zardoz]

That sounds great!