Here are some very important quotes from the study:
>>> ' Another important take-away (although not specifically addressed in the Hogg et al. (2018) study), is that there are an increasing number of studies suggesting that IR negatively impacts dopamine functioning in the brain. ' >> ' This study suggests that nearly two thirds of non-diabetic people with PD may be insulin resistant, despite having normal blood sugar, and in some cases, despite being lean. ' >> ' IR is thought to precede the development of T2D by 10 to 15 years. ' <<<
Since both diabetics and people with PD are at increased risk for Cardiovascular disease(CVD) and the fact that CVD is the number one cause of death in the world, melatonin has shown benefit in preventing and treating CVD :
Levodopa usage has shown to contribute to gut dysbiosis while PwP typically are already suffering from gut dysbiosis and melatonin may be able to help in this area also :
If you have issues or side effects with taking oral melatonin, there are multiple ways to naturally raise your melatonin levels without supplementing it and these options come with no side effects other than improved health :
Somewhere i heard that we should only take it for jetlag. Have you read or heard this? I take it all the time. My sleep is so improved because of melatonin!
Usually I have read that in older articles or articles that don't have studies as a basis. Studies, especially newer studies continuously highlight the multiple health benefits of melatonin. The newest studies are starting to highlight the health benefits of high dose melatonin such as this 250 mg/day RCT in diabetics :
Good that it helps you with tremor. I am interested in the sum total of potential health benefits that melatonin has to offer us and that is a substantial list and all that melatonin does for us is not yet known.
Sorry, Art. I noticed immediately i typed the wrong name. I just edited but was caught in fraganti. Im only getting to know you all and got the conversations and names mixed up...i could blame Pd but reality is ive always been a bit "scattered"...whoops
I couldn't believe the potential 500mg a night dose of melatonin (two tablets) used in this study so I emailed the author. Turns out the 250mg refers to the weight of the tablet which is a little confusing and in each tablet there is 3mg of melatonin, so they were getting 6mg a night.
Very good results for 6 mg a night, but that was a very poor way that they described the dosage.
In this older study in ALS patients they used 300 mg/day dosing via rectal suppositories to reduce oxidative stress levels to normal levels. This dose delivered rectally for up to two years is important because rectal dosing is thought to significantly improve melatonin bioavailability which is thought to vary between 3 to 15% when taken orally.
So this dosing level has been done in humans for well over a year already. It would just be nice to see this dosing level done in PwP. They've already done one study at 10 mg and two studies at 50 mg in PwP, but they have not as yet gone into this range of dosing that has already been proven safe.
Here is a link to a 400 mg suppository available on Amazon :
Agree wit Art who knows so much about this subject! Also, William Faloon, the founder of the Life Extension company, just published an article "A case for higher-dose melatonin" where he states that after experimenting with different dosages, his average nightly melatonin dose now is around 20mg.
World renowned melatonin researcher, Dr. Russell J. Reiter has mentioned using 100 mg or more per night everyday. I am using 120 mg minimum per night after completing a full year at 106+mg/night.
You are a brave and knowledgeable trailblazer Art - I wish to have a fraction of your knowledge and courage to try new things. Unfortunately after a few food and meds allergic reactions in the past now I feel that with anything new I should proceed low and slow.
If you are asking about Dr. Reiter's daily dose, he stated it in one of his YouTube videos. Dr. Shallenberger is quoted as saying that he takes 180 mg/night and he recommends all of his patients take 180 mg per night except for his stage 4 cancer patients who he suggests 360 mg/day in divided doses around the clock. Here is a link to a video where Dr. Reiter gives the dose he uses of 100 mg/day.
I am interested in hearing from those who take melatonin and what improvements specifically it has produced. I expect better sleep but what are the other areas of improvement and also what amount is taken. My husband with Parkinsons takes it but not a very high amount. (6 or 10 mg) I also wonder if anyone quit taking it because of problems. I have tried taking it to help with sleep and often it gives me vivid, terrifying nightmares which definitely dampens my enthusiasm for taking it. The reason my husband started taking it initially was our naturopath told him about a protocol that was supposed to help with GERD and melatonin was part of that along with methionine, tryptophan, and methylfolate.
Im new to melatonin. A month or so...i went from 5 mg to 10mg and would increase to as much as possible 8f i found an affordable source, as i feel the effects already. My tremor is slightly less. I sleep like a log, and the quality of my dreams have changed from scattered post traumatic dreams to not remembering much of my dreams but the feeling that im visiting a new world altogether...i know it sounds weird but i have worked with my dreams for years and this feels new. 8 think my sugar levels were pretty ok too...
I've been taking HDM for over a decade. I did start at a lower dose of just 30 mg/day and then when a particular study came out that grabbed my attention, using 70 mg /day of melatonin for 9 months in children with muscular dystrophy, I increased my dose to 70 mg/day after reading the study. Here is a link to that study :
Almost 2 years ago I increased my dose to 106 mg/day and I used that dose for a full year and am now at 120 mg/day and plan to stay at this dose until I complete a full year. I may go higher after that, based on studies.
The highest dose I have used is 180 mg, but only for a short period.
The main thing that I have accomplished with HDM is I no longer get life threatening psoriasis flare ups, because the two severe forms I have can kill you and those flare ups have landed me in the hospital 3 times. I still have psoriasis but it is well controlled now. Other than that, I am trying to avail myself of the CVD and osteoporosis preventing effects and multiple other health benefits suggested by studies regarding melatonin.
Knowing that melatonin levels continuously decline with age and knowing the known health effects of melatonin makes me want to keep my level closer to levels seen in healthy young people.
I take 12mg at night. With broad spectrum cbd. Sublingual. That combination cured my sleep problems that had caused 10 years of misery. I take a lot of supplements so it’s difficult to isolate any specific motor symptom changes to just the melatonin. Also I’m asleep when the 12mg is sloshing about in my system. Sleep is the major change. I do have very vivid dreams sometimes but I wouldn’t class them as nightmares per se.
I notice a change in my dreams also, but it is hard for me to describe. The best description I can think of is that they seem more real, but I still forget them quickly and usually can't remember them by morning.
Yes, Art. Totally can relate to this. A sense of something new. A new world. As dres usually spek inmetaphors i would say the melatonin may be renewing me somehow...
I don't see any major effects other than helping fall asleep. And, as long I am adjusting TTDF (B1), I don't need to add another variable. healthunlocked.com/cure-par...
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