Instead of Mega Dosing B1, Try TTFD - Cure Parkinson's

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Instead of Mega Dosing B1, Try TTFD

Gcf51 profile image

Warning healthunlocked.com/cure-par...

I have negative feelings about mega dosing Thiamin HCL (B1), {Just to hope that some of the Thiamin gets in your brain cells (100mg is 6,667% of the RDA, It is suggested that we are suppose to take 200 times that and, the 200mg I take makes no difference)}. According to RDA 25mg of B1 is more than 2000% of what you need to function.

Thiamine {tetrahydrofurfury disulfide (TTFD/ allithiamine), on the other-hand has been shown to increase B1 in brain cells and I felt the difference in one 50mg dose. The TFD component which is shed when entering your cells does require methylation, but I take way more than 50mg of methyl donors. So, I ask: How is the HCL component you take disposed of? I am not a doctor: It’s probably just a little additional stomach acid.

TTFD is a form of thiamine that is water-soluble, and much more difficult to find in vitamin shops. Brand names include Lipothiamine, Allithiamane, Adventan, Alinamin-F, Benlipoid, Bevitol Lipophil, Judolor. my TTFD comes in 50 mg capsules. And the primary side effect is you smell like garlic after taking it. (Well, I haven’t smelled my breath) nootropicsexpert.com/vitami...

And, Thiamine tetrahydrofurfuryl disulfide (TTFD) is the synthetic counterpart of allithiamine, occurring naturally in garlic. Allithiamine was discovered in Japan in 1951... its metabolic effect was (is) much more powerful than the thiamine (assume they mean HCL and wonder how much more powerful). pubmed.ncbi.nlm.nih.gov/153....

excellent Video on TTFD (doesn’t work as I expected - I had to page dn) healthunlocked.com/cure-par... ***If it increases dopamine in brain is it a cure????

You may ask, what difference: It’s nice to be able to brush my teeth without my hand doing something crazy. And yes, I am still taking the 200 mg of Thiamin HCL.

116 Replies

Only day 2 and can't rule out Placebo.

Thiamine is an important B vitamin that plays a vital role in production of energy from food consumed. It also improves normal neuronal activity. Come on Mitochondria make some ATP, the energy is invigorating… Thiamine, increase my nerve shielding too…

So you have good experience after 2 days?

Gcf51 profile image
Gcf51 in reply to nedim

Yes, having problems going to sleep, maybe the extra energy, can't seem to stop random/rapid thoughts. I took my previous dose some 16 hours ago so should not be the TTFD. Just took 5mg melatonin, hopefully it will shut the thoughts down.

Michel0220 profile image
Michel0220 in reply to Gcf51

Maybe try taking B1 in the morning. I try to avoid taking it after 11.30 as I found it otherwise messed up with my sleep (I am on 2.5g/day).

Gioc profile image
Gioc in reply to Michel0220

IMO should be split 4/6 times a day. Even just 250 mg b1 hcl. So unnecessary overdose is avoided and the availability over time that is what is needed given the high speed at which it is expelled from the body is prolonged.

healthunlocked.com/cure-par...

Gcf51 profile image
Gcf51 in reply to Gioc

The TTFD is more absorbed into cells (as I understand). It is water soluble, so excess should still be flushed out. From my experience (at 50mg) taking 2-3 grams would be way too much of TTFD, even though by what I have read it would be safe to take.

Gioc profile image
Gioc in reply to Gcf51

I don't know TTFD very well, I've never used it. You definitely know it better than me.

AmyLindy profile image
AmyLindy in reply to Michel0220

Same - earlier dose is better due to energizing effect

Gcf51 profile image
Gcf51 in reply to Michel0220

TTDF is part of my morning stuff without food..

Dap1948 profile image
Dap1948 in reply to Gcf51

Problems going to sleep and random/rapid thoughts sounds like overdose to me…

Gcf51 profile image
Gcf51 in reply to Dap1948

Really, I am only taking 50 mg TTFD and 200 mg of T-HCL. Everything I have read indicates both are safe in a couple of gram doses.

Dap1948 profile image
Dap1948 in reply to Gcf51

I don’t mean that it’s unsafe when I talk about an overdose. You have to find the dose which improves symptoms in the B1 therapy and if you take too high a dose for you it can make symptoms worsen. We refer to this as overdosing. All in my book amazon.co.uk/Parkinsons-The...

Gcf51 profile image
Gcf51 in reply to Dap1948

I will email my Doctor at the VA, to order me a blood test.

Dap1948 profile image
Dap1948 in reply to Gcf51

A blood test for thiamine doesn’t show a deficiency before the therapy.

AmyLindy profile image
AmyLindy in reply to Gcf51

I’m seen at the VA too . They’re restricted in ordering labs to some extent but I did get a T4, B12 and C Reactive Protein yesterday (for “justified” reasons, outside of PD).

If you get B1 labs 🧪 I’d be surprised 😲 - please report!

Gcf51 profile image
Gcf51 in reply to AmyLindy

Did get results about much later date. My blood test from day 3 of 1--50mg of a cap a day was 260 with mid-range of normal results being 23, my results 11.3 fold above mid range.

Gcf51 profile image
Gcf51 in reply to Dap1948

I wish I had listened to you sooner,

Only slept 2 to 2-1/2 hours. Woke up thinking I slept much longer. Made a cup of decaf coffee encase I go back to bed.

HekateMoon profile image
HekateMoon in reply to Gcf51

I started two days ago. So far very deep sleep. No other effects that i notice

Sublingual doses are very small too and go straight into the bloodstream. Most people take about 50mg a day or one sublingual 100mg tablet every other day. I have yet to receive reports from people with Parkinson’s on TTFD that they have found any success. Whereas I daily receive success reports from people on HCL and sublingual B1. I cover all this in my book “Parkinson’s and the B1 Therapy”. Be careful you don’t overdose!

rescuema profile image
rescuema in reply to Dap1948

Hi Daphne,

How many people do you know who have tried TTFD? Have you tried it?

I believe you'll tend to hear more success stories with HCL because people are more motivated to try Dr. C's specified protocol, not because other forms were found ineffective. I have yet to notice anyone stating that TTFD didn't work for them while a high dose of B1 HCL worked better for their PD.

Of all PWP who vocally championed B! HDT, I know RoyProp was one who initially benefited from Benfotiamine and TTFD, so you might want to avoid stating yet to "have found any success."

healthunlocked.com/cure-par...

"Thiamine could be converted to three phosphorylated forms, thiamine monophosphate (TMP), thiamine pyrophosphate (TPP), and thiamine triphosphate (TTP), after intestinal absorption, but the rate-limiting transport system for thiamine absorption causes a bioavailability issue ...

The derivative, TTFD, is synthesized by attaching a mercaptan to the sulfur atom of the thiazolium ring. The mercaptan, left outside the cell membrane as the complete molecule, is hydrolyzed to deliver thiamine into the cell and has been well studied for its metabolic breakdown [17]. This transit through cell membranes provides a high concentration of the vitamin in the cell and the reaction does not require a transport system to assist in intracellular absorption of thiamine [18]. The bioavailability is significantly higher than thiamine salt in a variety of organs."

ncbi.nlm.nih.gov/pmc/articl...

Despe profile image
Despe in reply to rescuema

Rescuema,

I believed that TTFD is fat soluble, am I wrong?

Gcf51 profile image
Gcf51 in reply to Despe

I thought so too, but Nootropic say water. I saw somewhere else too. nootropicsexpert.com/vitami...

Despe profile image
Despe in reply to Gcf51

hormonesmatter.com/ttfd-thi...

Comments and responses from Dr. Lonsdale are very educational!

rescuema profile image
rescuema in reply to Despe

No, it's water-soluble. See my past response below - healthunlocked.com/cure-par...

Despe profile image
Despe in reply to rescuema

OK. Thank you! I believed Dr. C preferred HCL because it's water soluble whereas the other forms of B1 are fat soluble.

rescuema profile image
rescuema in reply to Despe

If you're monitoring thousands of patients, as a scientist it would be best to limit variables as much as possible and I'm sure he was more familiar with B1 hcl for mechanisms and side effects.

Despe profile image
Despe in reply to rescuema

nootropicsexpert.com/sulbut...

Rescuema,

What do you think about Sulbutiamine? Thank you.

rescuema profile image
rescuema in reply to Despe

I experimented with it but didn't notice any benefit over what I was already taking. I also remember noticing more negative reviews on the form compared to others, so I don't see a reason to pursue that form over the others.

Despe profile image
Despe in reply to rescuema

OK, thanks! I always value your insight, you know it. :)

HekateMoon profile image
HekateMoon in reply to rescuema

Starting TTFD. Will report in a few days

How is the TTFD going?

Gcf51 profile image
Gcf51 in reply to Bolt_Upright

See today's Update: healthunlocked.com/cure-par...

One reason people need to take high doses of B1 when using the ORAL version of the supplement is that so much gets lost going through the gastrointestinal system. This doesn’t apply with injections or sublingual.

Gcf51 profile image
Gcf51 in reply to Dap1948

But, I am taking them orally.

Gcf51 profile image
Gcf51 in reply to Dap1948

I requested admission to your facebook page. Also sent my doctor a request for a B1 blood test.

Dap1948 profile image
Dap1948 in reply to Gcf51

I accepted your request and sent you a personal message!

youtube.com/watch?v=hLq3rlH...

Gcf51 profile image
Gcf51 in reply to nedim

Thanks watching now.

Dap1948 profile image
Dap1948 in reply to nedim

All types of thiamine boost dopamine levels

nedim profile image
nedim in reply to Dap1948

dopamine levels in the brain? interesting. any links?

Dap1948 profile image
Dap1948 in reply to nedim

Sorry I’ve answered your question but it hasn’t linked with you! Can you see it below/above?!

Gcf51 profile image
Gcf51 in reply to Dap1948

If increases in brain, is it a cure? My understanding is High Dose B1 still have to take l-dopa.

Dap1948 profile image
Dap1948 in reply to Gcf51

Dr C used to explain that when neurons were dead they remained dead and therefore you had a reduced dopamine production and still need levodopa meds to replace the short fall. However B1 would stop further neuron death and save the dying neurons.

Gcf51 profile image
Gcf51 in reply to Dap1948

I don't like that. I take stuff to clear the cobwebs in hopes that they are still alive. Maybe wishful thinking.... But I am sticking to it...

Dap1948 profile image
Dap1948 in reply to Gcf51

👍🤣😂

Despe profile image
Despe in reply to Gcf51

Neurons don't die, they HIBERNATE!

rescuema profile image
rescuema in reply to Gcf51

The neurons are not all dead. A good portion of the cells is in a dormant state. See related discussions below.

healthunlocked.com/cure-par...

Despe profile image
Despe in reply to rescuema

Yes, I remember. I also posted Dr. Bergman's video presentation in which he discussed PD and neurons.

I have a whole page in my book in a section entitled “the link between PD and thiamine” which includes quite a number of references. Here are two studies which link thiamine and dopamine…Onodera K, (1987). ‘Effects of decarboxylase inhibitors on muricidal suppression by L-dopa in thiamine deficient rats’

Lu’o’ng Kv, Nguyen LT (2013). The beneficial role of thiamine in Parkinson’s Disease’

The book contains more on page 12 - amazon.co.uk/Parkinsons-The...

Just took my 3rd dose of 50mg and no C/L. Maybe I don't have PD, just had a thiamine deficiency.... Ok... Wishful thinking. Later that day I took C/L.

parkie13 profile image
parkie13 in reply to Gcf51

What you have right now is Placebo.

Gcf51 profile image
Gcf51 in reply to parkie13

Possible... Later that day I took C/L.

Mosquitoes have always loved me. There can be 10 people and I will be the first person to be swatting mosquitoes. I live a half mile across the river from Augusta GA. I was outside in shorts and a tee. Three landed on my legs and I killed them. So, I let a mosquito light on me, it few off and landed in another spot three times, before I killed it. If I do smell like garlic, I guess no one will be kissing on me unless they have been taking TTFD too...

rescuema profile image
rescuema in reply to Gcf51

You got me chuckling because I was the same. Mosquitos swarmed me in the midst of a crowd of people until I supplemented high-dose thiamine. For other people confused about why you're talking about mosquitoes -

justvitamins.co.uk/blog/tak...

jstage.jst.go.jp/article/bp...

Gcf51 profile image
Gcf51 in reply to Gcf51

Most literature says B1, but it took adding 50mg TTDF to stop it. Maybe mega dosing stops it, but my 200mg didn't.

rescuema profile image
rescuema in reply to Gcf51

How long have you supplemented 200mg consistently? Your thiamine-dependent enzymes may have been long lacking cofactors with severely compromised transport function. Heavy alcohol use or eating high refined carbs/sugar will also deplete B1, especially out of the brain. For reference, beriberi patients need a minimum of 100mg three times a day for many months to start recovering. Some people are also genetically compromised to absorb thiamine, such as in SLC19A3 gene.

Gcf51 profile image
Gcf51 in reply to rescuema

Been taking a B-Complex for as long as I can remember, added B-1 about a year ago per a doctor.

rescuema profile image
rescuema in reply to Gcf51

I've also been taking a B complex and good multivitamins forever, so the idea of being deficient in any vitamin was hard to imagine. I'm glad you're responding to TTFD. The article below will explain why a high diffusion is needed in case of severe thiamine deficiency.

"The treatment of clinical manifestations of thiamine deficiency, especially WE is a medical emergency, and in patients in whom the disorder is suspected thiamine should be initiated immediately, either intravenously or intramuscularly, to ensure adequate absorption.58 Studies11,31,48 support several different regimens for patients with the disorder and those at risk of developing it.

Specifically, patients who have signs indicative of WE should be treated empirically with a minimum of 500mg thiamine hydrochloride per 100mL of normal saline, given by infusion over a period of 30 minutes, three times per day for 2 to 3 days. In cases where there is no response, supplementation may be discontinued after 2 to 3 days. In cases where an effective response is observed, 250mg thiamine should be given intravenously or intramuscularly daily for 3 to 5 days, or until clinical improvement ceases, and should be continued. Doses of thiamine below 250mg per day apparently may not restore vitamin status,59,60 improve clinical signs,61 or prevent death.62 In particular, when patients with WE are inappropriately treated with low doses of thiamine, the biochemical abnormalities caused by thiamine deficiency can lead to irreversible brain damage and death."

ncbi.nlm.nih.gov/pmc/articl...

Gcf51 profile image
Gcf51 in reply to rescuema

But applies to HCL, not necessarily TTFD.

rescuema profile image
rescuema in reply to Gcf51

Precisely. I was mentioning the article to illustrate why you have not responded to long-term oral 200mg B1 hcl as would in other severe thiamine depleted patients with compromised transporter functions requiring a much higher dosage (parenteral no less) but you seem to be responding to TTFD that readily crosses the BBB without depending on transporters.

Update as day 3 closes. I feel fine. Great considering I got less than 2-1/2 hours sleep last night. Even cut back my C/L to 1-1/2 twice a day.

in reply to Gcf51

I really appreciate your sharing your personal experience. Mine is on order.

It would be nice if we were to create groups to try new things simultaneously. But I suppose communicating about it would contribute to placebo affect. But we could agree to start something and not communicate about it until the end of a set period and someone not participating, someone analytical like Park Bear, could question us. This is about a high school level science project so some may laugh at my idea but I think it has a little validity?

Hikoi profile image
Hikoi in reply to Gcf51

So now with the change in C/L dosage how can you tell what effects are from thiamine therapy and what from drug changes?

Gcf51 profile image
Gcf51 in reply to Hikoi

That is one of the reasons why I wouldn't be a good guinea pig.

Hikoi For more on subject, see my profile's bio (I have not undated in awhile, But that part hasn't changed).

Update: 2 hours after taking my 4th dose of 50mg: I can feel them. Maye, they are goosebumps. I am excited or maybe my body is thanking me for giving it something it needed

Went to bed around 10, don't remember laying there any period of time. Got out of bed at 6:20. Took my morning meds. Holding my coffee cup rock steady. I feel rested.

Comment: Yesterday I notice my skin on my forearms looks a little like chicken skin (mini-goose bumps - light colored slightly raised spots). They don't feel like they are bumps. Why, I speculate, something being expelled from my body...??

I remember reading somewhere that analysis of human urine byproduct reveals TTFD is 100% absorbed.

Day 4 out to a good start...........

It is so effective, I have to question, do I have Parkinson's or did I have a B1 deficiency.

😀

I add judging from my reaction - I wouldn't recommend taking more than a 50mg dose.

Please excuse me... I'm so excited I can't stop editing/posting. Reminds me of DSMO - Stuff so absorbable, you can put a drop on your big toe and "with little or no delay" taste it in your mouth (major side effect bad breath).

Maybe, researchers need to attach TDF to more stuff

😀😀😀😀

DSMO, so absorbable you have to be careful what you mix with it, it will sucks contaminates in with it. The stuff in the movies, spy's mix with poison, put of a glass, someone picks up the glass and they fall over foaming at mouth.

I googled (dmso vs "tetrahydrofurfuryl disulfide") and got so many hits, but can't find one that says TDF is a component of DSMO....

TTDF was developed in Japan where/when/while Beriberi was a major problem – Did the researchers there have DSMO in mind. B1 treats Beriberi.

Again excuse me, I have an engineering degree and had major problems passing English courses.

I got stressed and started shaking. Do take more C/L or more TTDF. I chose C/L after all as I understand mega dosing B1, you must mega B1 for life (Oh well, could justify both choses with that).

rescuema profile image
rescuema in reply to Gcf51

" as I understand mega dosing B1, you must mega B1 for life"

- No. Most people titrate down.

Your requirement for magnesium will go up with TTFD, so be sure you're supplementing, especially in times of stress.

Gcf51 profile image
Gcf51 in reply to rescuema

Magnesium is in my stack... And is on my list of must have, Been there every since I read an article "Is it Parkinson's or Magnesium Deficiency" which was pretty near to when I was diagnosed with parkinsonism and later a Dat-Scan showed positive for PD.

According to RDA 25mg of B1 is more than 2000% of what you need to function and most doesn't get to the brain.

I wonder if just adding more garlic to your diet works. It would be unadulterated and unprocessed so one would think it would be better than adding another supplement. Have you found any information related to allithiamine from food versus supplements?

Gcf51 profile image
Gcf51 in reply to wifeofparky

might, but according to what I have read might take a ton...

I had a great night of dancing with more energy than I have had in a long time.

Update Day 5… other things are stressful in my life (It’s not just that my PD was getting worst, which was very depressing).

About breath - Yesterday, I told my favorite dance partner to let me know if my breath was bad. Last night she didn't say anything. So, I asked at the end of night. She replied, not that I noticed and nothing offensive. All I ready can say, Mosquitoes don't love me anymore. Maybe, breath is not a problem a 50mg a day.

Yesterday, I noticed I now have a tendency to walk to left (probably because, I have had a tendency to walk to the right and my brain needs a little retraining). I had been told the reason I walked to the right was because my brain told my foot to take a 2 ft step but my foot moved slightly less.

I had a great time dancing last night. I had more energy and better balance & coordination. And, my shoulders didn’t ache like my arms had been holding up 50 lb weights for hours (90% better).

Odd… I have a bad neck. My neck pain has been much less (90% better) since starting TTDF. The odd part is my pain got worst shortly after taking my C/L for maybe 45 minutes (at one time I was using my neck pain as gauge for is I was taking enough C/L healthunlocked.com/cure-par....

Still wondering, did I have PD or a B1 deficiency, but at only day 5 and I cannot rule out placebo effect.

I am a sugar Junkie. I don't buy bags of candy because I will eat the whole bag in a few hours.

healthunlocked.com/cure-par...

The problem(s) with being your own human guinea pig: Copied from Profile Bio.

- In PD the Placebo Effect is STRONG because thinking you feel better produces dopamine and too little dopamine (in your brain) is the reason you were prescribed Levodopa.

- I practice a little of what doesn’t kill you, makes you stronger. (On this Forum I don’t want to be the cause of someone else’s death – I don’t tell all).

- What to use as a gauge (Currently, how often does my right hand shake – presently almost only when I am trying hard to have a bowel movement)(one time neck pain, I got up to 12 Levodopa a day). (after taking TTDF, I am considering cutting cutting back)

- I try to stay with recommended dose, but sometimes there is no recommended safe dose.

- I don’t want to kill myself, but I look at those in a support group with advanced PD and think I don’t want to be like them (I don’t know how I will feel, if get that bad,)

- I don’t want to be a part of a clinical trial; I want to know, I am taking the real thing and not a placebo; I want to try more than one thing(s) at time.

- How many things do I try at the same time and for how long do you try each?

Update Day 6 of 50mg of TTDF

I feel, I am at where I was way before being diagnosed with Parkinsonism (6 months later PD was confirmed via DatScan).

I tried to cut back, but I am back to 2-1/2 C/L twice a day (I got stressed and had a little Tremor). Tremor isn’t nonexistent, but I can stop it. I can remember periods way back (more than 15 years ago) of spilling stuff.

I was diagnosed with Parkinsonism when I went to the ER due to Vertigo (I was rolling my fingers and it was very uncomfortable for me to stop it). I have not notice doing this since starting TTDF. Yesterday, I notice while wearing a fairly new pair of shoes a little vertigo (they are now in the trash).

I have x-rays showing I have a bad neck (neck pain improvement - 90% improved).

I understand TTDF is also good for fibromyalgia pain too (pain in general down 90%).

Fatigue – Energy level is very high (maybe too high).

I still need fiber for a good bowel movement.

Sleep for 2 days has been back to my normal of 5 to 6-1/2 hours.

Mosquitoes now hate me… A google search indicates B1 keeps insects away (I sure hope Deer Flies too). I will pay the cost of TTDF just for insect repellant…

Still wondering, did I have PD or a B1 deficiency, but at only day 6 and I cannot rule out placebo effect.

I was diagnosed as having Bipolar Tendencies 4 decades ago. After 6 months of being on as many as 4 antidepressants and 3 mood stabilizers (at the same time) I concluded if one of us (doctor and me) is Bipolar he is. Maybe, I am feeling too good and should take a mood stabilizer before I crash. I understand... why someone with Bipolar will go off meds - WHY KILL A GOOD THING.

park_bear profile image
park_bear in reply to Gcf51

Three different substances that should result in improvement have caused me vertigo. My theory at this point is that they are improving the neurological connection to my vestibular organs, and that improvement is causing vertigo. I am trying low doses of one of these substances (fish oil) and hope to be able to gradually increase my dose.

----

Feeling good is great! Unless something extreme is going on - like a manic episode - just enjoy it.

in reply to park_bear

Are you aware that vertigo can be a sign of or result of autoimmunity?

involvement. Vertigo and other audiovestibular symptoms may be the first manifestation of an autoimmune disease and if correctly addressed could significantly contribute to early diagnosis of the underlying autoimmune disease. Early diagnosis of immune-related vertigo can lead to prompt initiation of targeted therapy

pubmed.ncbi.nlm.nih.gov/302...

park_bear profile image
park_bear in reply to

In my case I am vulnerable to vertigo due to an acoustic trauma I suffered many years ago.

in reply to park_bear

I’m sorry to hear that PB. My mom has vertigo that comes and goes. I still am albeit stubbornly holding on to that there could be an autoimmune component in addition to that acoustic trauma. This is relevant bc the autoimmunity can be a contributor to PD so it’s not isolated.

I just ordered Thiamat from nnotropics. Ill keep you posted when i take it.🙏

1 week of taking 50 mg of TTDF At one week could be a Placebo

(Probably longer than most will Read)

This being a week I will try to be more specific

Recommendation: Don’t take more than one 50mg dose. If anything try to somehow to take only half a cap for a couple days. I don’t know what it tastes like. The bottle doesn’t smell bad today (maybe because I have been taking). Since the RDA of B1 is only 1.1 mg daily, it is a shame you can’t buy a smaller dose. TTDF is water soluble. Analysis of human urine for the byproduct indicates it is 100% adsorbed. TTDF crosses the Blood Brain Barrier (thiamin HCL does not). The TFD component which is shed when entering your cells does require methylation. Both folate and vitamin B12 are the important regulators of DNA methylation .

When a Cure is found I believe it won't be just one thing - It may be something else in my stack working in conjunction with.

Processed food are fortified with B1 (thiamine HCL is the most common which doesn’t cross the BBB). With the rise of neurological diseases they should fortify with TTFD.

Sorry, just noticed the product I am taking is labeled on the back (50mg of TTDF) - I have no idea of the weight of the TDF component, therefore no idea of how much B1.

Supposedly, TTDF gives you bad breath. I went to my daughter’s and she didn’t notice anything on day 3. On day 5 my dance partner, said “not that I noticed and nothing offensive” when I asked. I have not tried to kiss anybody. There are a few ladies, I dream of kissing, but have not and I doubt if they would let me. Mosquitoes now hate me. I just went outside and I did not see any of them flying around me. Deer flies still buzz my head (those things hurt and I tried not to let them land on me). No noseeums are not repelled.

I will try to be candid (list from a source, not my list) and this is what made so long.

Tremors (99% improvement): I have not caught myself rolling my fingers, but tremor is not nonexistent.

Rigidity: (90% improvement) My shoulders no longer feel like I have been holding 50lb weights for an hour.

Bradykinesia: I will have to wait for my Motion Specialist (MS) to determine, my next appointment is 7/14/22.

Vocal Symptoms: I have always stuttered and stumbled on my words (I do feel more confident and I am more talkative).

Postural Instability: I will have to wait for my Motion Specialist (MS) to determine, my next appointment is 7/14/22.

Walking or Gait Difficulties: I walked a mile yesterday with no problem.

Cognitive Changes: I feel my thinking is a lot clearer.

Depression and Anxiety: If anything, currently in a mania phase.

Disturbances in the sense of Smell: I think improved.

Eye & Vision Issues: Yesterday during my 20 minute fast walk, I did not wear by glasses and without my glasses I see 2 birds on a power line instead of one; when I got back I had cover one eye to read (problem reading only lasted 5-10 minutes). I intend to try to only wear when reading.

Fatigue: My energy is much higher

Gastrointestinal Issues: Still need fiber for a good bowel movement. My belief, this is cause by med of PD which I am still taking.

Lightheadedness: I never have had major problem and have had no occurrences since starting TTDF. I have had no Vertigo since starting TTDF.

Melanoma: My last visit with a specialist revealed no areas of concern. A couple of areas of dry skin (seborrheic dermatitis) cleared with medication but returned.

Pain: My bad neck hurts 90% less. With my increased energy I have noticed burning sensation on top of my thighs, I may have pinched a nerve in my back, I am standing, I am walking; if so 99.999999% improvement.

Psychosis: Never had this problem.

Sexual Concerns: Judging from my dreams greatly improved. Concern: What's Sex? LOL

Sleep Problems: TTDF has increase my energy and increased rapid/random thought and I wake early (-50%)

Sweating: I have not broken out in a heavy sweat since starting TTDF. I don’t seem to be as temperature sensitive.

Urinary Issues: I was on (MIRABEGRON 25MG SA TAB) because of problems of holding it, but I have had major dry mouth problems and quit because that was listed as a possible side effect.

Weight Loss: None since starting TTDF.

Levodopa and Carbidopa side effects.

Dizziness (see above)

Loss of appetite: Opposite since starting TTDF

Diarrhea (see above)

Dry mouth: I am having major problems which seem much worst with TTDF, but may be because I have Botox injections for drooling 6 weeks prior to starting, and botox probably won’t be wearing off any time soon.

Mouth and throat pain: None

Constipation: (see above)

Change in sense of taste: (see above)

Forgetfulness or confusion: (see above)

FYI-

I was diagnosed as having Bipolar Tendencies 4 decades ago. After 6 months of being on as many as 4 antidepressants and 3 mood stabilizers (at the same time) I concluded if one of us (doctor/me) is Bipolar he is. Maybe, I am feeling too good and should take a mood stabilizer before I crash. I understand fully... why someone with Bipolar will go off meds - WHY KILL A GOOD!!! I also, have kinfolk with Asperger's..

You will have to look at the whole post and read my comments for days 1-4 healthunlocked.com/cure-par...

Update Day 5 healthunlocked.com/cure-par...

Update Day 6 healthunlocked.com/cure-par...

park_bear profile image
park_bear in reply to Gcf51

Great news GCF!

> Deer flies still buzz my head

Biting flies are attracted by heat not smell

This part not abnormal:

> Still need fiber for a good bowel movement.

Gcf51 profile image
Gcf51 in reply to park_bear

Agree

chartist profile image
chartist in reply to Gcf51

Thank you for the one week update report and I look forward to your future updates!

Art

Fed1000 profile image
Fed1000 in reply to Gcf51

Hi GCF, which product are you using?

Gcf51 profile image
Gcf51 in reply to Gcf51

I keep editing so might want to look at again.

I intend on posting a link on my Facebook as life changing event. Maybe, I will wait a little longer, so I am positive it's not 95% Placebo.

Gcf51 profile image
Gcf51 in reply to Gcf51

I opened a capsule and poured the contents into a spoon. There was not a lot of small grainy powder. I wet the tip my finger, touched the contents and put on my tongue; a not good taste but not totally repugnant either; and not completely unlike the odd taste in my mouth after taking 1 50mg for 8 days. The little bit on my finger probably exceeded the RDA of B1 (Not a very scientific test). I wonder what the half life of TTDF is? I understand B1 is recycled in body. What is consumption?

I am using and I now have more than 490 day supply of worst case insect repellant walmart.com/ip/Allithiamine... Fed1000

Maybe, I am saying dry mouth wrong; it’s more of a cotton mouth. I had this dry mouth before starting TTDF, so it’s not TTDF.

11:30pm. I had a dream. I was standing on the new roof that I just had install at my daughter’s house. Buckets of water were being thrown at me. I couldn’t see who was throwing the water. I was about to be washed off, when I woke up... My excessive dry mouth is mostly normal and I have the thought in my head “stop the 100mg of B1 HCL”. I got up and ate some ice cream. And, decided to write the dream down. My sinuses are draining and my lungs are a little congested. So, I took a NAC. I just heard the sound of a very short/light rain shower on my roof. I stepped outside the rain is very light. My bottle of 100mg B1 is now on the shelf of stuff I don’t take. I ate a little more ice cream. Its 12:50, I’m going brush my teeth and try to go back to sleep.

2:30 I woke up again. I don’t have a clock that I can see from my bed (too irritating if I have problems sleeping). Hungry, TTDF has defiantly increased my food consumption. Dang… my dry mouth is back. This time a cup of decaf and 8 saltines (unsalted tops) and peanut butter. I didn’t go right to sleep, so maybe more than an hour. I’m walking around barefoot every since I threw away the scandals in day 4 or 5. Defective K-cup a few grounds in coffee. This is differently not my normal sleep pattern. I am rock steady with coffee cup. Not enough to shut down hunger, maybe a little more bulk is needed, I will try a little equate Metamucil. Feel wide awake probably couldn’t fall asleep if I go back to bed.

Oh…. I don’t think, I have mentioned, Antibiotic… I have taken Cephalexin before and it didn’t do what the 4 course antibiotic did when I had Sepsis (see healthunlocked.com/cure-par.... I had an abscessed tooth; my dentist says not a cavity, so has to be from dry mouth which brings up another story that should be mentioned too.

I smoked from 16 to 55 years of age. I was a 3 pack a day when I quit. I tried many times, patches leave red spots with white centers on my body (I was allergic to the glue), I finally quit with lozenges. Even got to the point I could smoke 1 and not want another. Anyway, I thought I would try lozenges to see if they would help with PD (my opinion, little to no effect). But, I am hooked again. The problem with lozenges is sometimes, you have white colored lips. And, with dry mouth always. The sweetener also hurts my tooth. I question, if the lozenges caused my abscess. I now am on a second course of antibiotic, if the tooth tightens back up I will have a root canal, but I am concerned that I will spend the money and still have to have the tooth pulled. I have posted bad reviews on product pages and have asked on a smoking forum “Does anybody make a lozenge that doesn’t leave white chalky lips with a sweetener that doesn’t hurt a bad tooth”, I have not gotten a reply.

5:33 I just took my morning meds which included TTFD and going have my 2 cups of regular coffee.

I must have a Thrush infection, brushing my tongue with salt water really helped with my cotton mouth, I wish my gag reflex wasn’t strong….

Very short lived.

Maybe this is a supplement to take for just a few days then a break etc.

I plan to open a cap and see how it taste. If I don't sleep tonight I won't be taking in the morning. Sydney75

I opened a capsule and poured the contents into a spoon. There was not a lot of small grainy powder. I wet the tip my finger, touched the contents and put on my tongue; a not good taste but not totally repugnant either; and not completely unlike the odd taste in my mouth after taking 150mg for 8 days. The little bit on my finger probably exceeded the RDA of B1 (Not a very scientific test). I wonder what the half life of TTDF is?

The bottle says 50mg of TTDF and doesn't say % RDA of B1.

It is supposedly water soluble, 100% absorbable; once in your cells how long to get used up!!!

Ok, some of you chemist out there; what's the weight of T and what's the weight TDF?

park_bear If I mixed a 50mg cap of TTDF with 10 mi of water, add a little sweetener; how much of the mix equals 25mg of B1?

Gcf51 profile image
Gcf51 in reply to Gcf51

Awful, after taste 50 minutes later.

day 9 I got my normal sleep about 7 hours

I have decided to take some off-time from TTDF. I did not take this morning.

How long: I will gauge by maybe; when Mosquitoes start biting me again, when energy level is a problem, when Tremor returns or something else.

I did have blood test run on day 3 for B1. No results yet.

Sorry, I noticed the product I am taking is labeled on the back (50mg of TTDF) - I have no idea of the weight of the TDF component, therefore no idea of how much B1.

Day 10 and 2 days of no TTFD, 5/25 4:00am: I did not take a dose of TTFD yesterday with my morning meds (last dose more than 47 hours ago). I won’t be taking today either. I do plan on taking a 50mg dose Saturday morning for energy to enjoy dancing that night. I am going to drink 2 cups decaf and might lie down again.

I still feel fine, but less mania (my night meds did not shut down the thoughts in my head. They were not as rapid). I will try not to rant and rave like I did the other night. I still have no major symptoms of PD. My neck pain is a little worst, but nothing Advil and Tylenol won't handle. I am still taking my 2-1/2 tabs of C/L. Yesterday afternoon, I did notice a few mosquitoes flying around my legs (one landed on my leg, I let it stay for a few seconds, it did not fly off so I killed it and I killed another while it was flying). Last night I wore long pants and long sleeves while outside.

Last night: went to bed a little before 10, woke from a dream at 11:30, went back to bed at 2:19, up again at 3 (not a good night’s sleep).

I would have probably not have posted my Event with my current state of mania or none of a few other things. Maybe, I should delete/edit some things, but they are all notes of an n1, non-placebo experiment (Note, one of the problems with being a self medicated human guinea pig). It’s now 5:30 and there is not a lot of sense in going back to bed.

I plan to try to calculate the % T in TTFD today (I want to know).

easier than I thought:

TTFD C17H26N4O3S2 398.5 thiamine C12H17N4OS+ 265.355 66.6% thiamine

50mg = 33.3 mg thiamine 2,775% of RDA (for men ages 19 and older RDA is 1.2 mg)

Maybe, I should have tried what Dap1948 is promoting, but I had never heard of it till posting. And, I now have more than 490 caps of TTFD. I wonder if it is as good of insect repellant.

Added at 9:10 am. I just went outside in shorts for 30 minutes - No Mosquitos. I have little neck and did not take anything for pain. I may not take any TTFD tomorrow (depends on how I sleep tonight).

At one week healthunlocked.com/cure-par...

Note: When I put on my tongue to taste. It taste bad, 45 minutes later after taste Awful.

Trying to steal a video clip Bolt_Upright posted from Nutty Professor youtu.be/zJbuxoZVPIg

Bolt_Upright profile image
Bolt_Upright in reply to Gcf51

I love that scene.

Bolt_Upright profile image
Bolt_Upright in reply to Gcf51

I was a huge Jerry Lewis fan and wanted to be like Buddy Love (I was not like Buddy Love).

5/28 Day 11, Day 3 no TTDF: Occasional very slight tremor, took my last of 2 weeks of Cephalexin 500g 4 times a day at 11:52am (hope tooth doesn’t abscess again and antibiotic is not part of the reason my PD is better). I am having dreams, so must be getting some REM sleep. I walk around mostly barefoot, every since I threw in the trash the sandals that made me walk drunk. I have a cold and won’t be going to dance tonight. Going to cut back C/L to 2 twice a day. The video I shared yesterday of Nutty Professor was more in reference to taking other stuff, than I mixed up a concoction. Mania: is much less. Energy: still high. Personally, I feel as if I have rolled back my life-clock more than 10yrs.

Last night’s Sleep: I remember thinking I wanted to go to bed early, so before 10pm and don’t remember taking forever to go to sleep. 1:30am: Woke up with a summer cold (squeezing, runny nose, cough, no fever), took a dose of Nyquil. 3:00am Try to go back to bed. 4:16am Woke up startled from a dream, still have cold, I remember dreaming I was at a picnic, then someone saying you are dreaming, I do not recall what startled me (thinking someone poked me with a stick). 4:30am made a cup of decaf. 6:05am Took morning meds and made a cup of regular coffee. 8:10am I took my morning meds which are best with food and are at least 1 hr after taking c/l. I got maybe, more than 4-1/2hrs of sleep. Note: Any trips outside after going to bed, I wear long pants and long sleeves.

Notes: . 1) Dap1948 She thinks I have overdosed on B1 (I thank her and wished I had listened sooner). 2) I like mania, but sometimes it makes you do stupid, embarrassing things. 3) I have received a few warnings about developing a pear shaped body,

5/29 Day 12, (Day 4 of no TTDF) I am at a good place 😀 Occasional slight tremor, I have been informed by Dap1948 that Pear-shape in England refers to any negatives (a), Mania: I think at good level (b), I got a good 8+ hours sleep last night. Pain: acceptable level. Insect repellant (c): acceptable level). I am taking (d). Appetite: very good (at some point I may need to watch my weight. I may edit so check this post later.

Most processed foods are fortified with B1 (which is most likely hcl which doesn't easily cross the BBB), with the raise of neurological diseases, maybe it should be as TTDF.

Notes, References, links, etc.:

😀 For me (everybody may require a different dose) and please consult your doctor and do your research. 🥵

🥵 Please (hover over or click-on) my profile pic and read the first line of my Bio.

(a) Dap1948 has inform me, that in England pear-shape refers to any negatives. and my reply. Oh... did not known that... Mania, Ranting & Raveling (more of caring on about nothing than loudly), (b), Seems to make dry mouth worst, Seems to increase need for more fiber, sleep disturbance.

(b) Mania: I like mania, but sometimes it makes you do stupid, embarrassing things (i.e. Posting a Pray Event on Facebook, etc,),

(c) Insect repellant: I have read that B1 repels mosquitoes (I will try to find a reference), all I can say, I was taking 200mg of (B1) HCL and it never helped me and mosquitoes now hate me. Dap1949 has indicated what she takes helps.

(d) walmart.com/ip/Allithiamine... Labeled as B1 on front label but only declares 50mg of TTDF on back (*). I calculated 33.3mg of B1 which is too much for me to take daily. The powder contained in caps taste bad with a very awful aftertaste lasting more than 50 min later. Maybe what Dap1948 takes works as well, she takes a half tab of hers.

(*) I would think not labeling in Nutrition Label would be a clear violation of FDA guidelines.

Gcf51 profile image
Gcf51 in reply to Gcf51

I have been told on mega dosing, you still have to take C/L. I would caution anybody on high dose about trying. All I can say is, for me it didn't matter and after a few days I quit most of the B1 I was taking.

Gcf51 profile image
Gcf51 in reply to Gcf51

Religion:

When I was on the board of Augusta Christian researching Robert’s Rules of Order, I remember reading the worst arguments in organizing is religious because each side thinks God is on their side. I will say if your say, if your side didn’t win, it’s might be time to reevaluate your beliefs, God is on the side of the righteous and the side that does to least harm to His plan. All Things are possible for those who believe.

Note: I have been using an old Version of word to spell check and grammar check what I write. Unfortunate it does not transfer my entire format to this forum. I cannot find a more recent bootlegged version.

GCF. Big ask but. Could you do a short consolidated (maybe 3-5) key takeaways at D=14? Word count <100? 😬I’m equally mesmerised and confused by the experimentation and the ebb and the flow that you’re going thru. Sorry if I’m being slightly thick. Just FYI I’m doing the Laurie Mischley ND protocol with some serious amendments but might argue that she’s potentially as of now myopic around B1, B2 and B3. She’s absolutely all over almost every other therapeutic supplement in the world tho. Ex Mischley I’m taking 300mg of Thiamine daily and about 750mg of TruNiagen the last month. As well as 2 tabs of PS128. And in short I actually feel worse the last month. Throwing money at the problem ain’t making it go away. Yet. 😉

Gcf51 profile image
Gcf51 in reply to JCRO

I am confused by "Could you do a short consolidated (maybe 3-5) key takeaways at D=14? Word count <100? 😬" I don't understand what you are asking me to do.

in reply to JCRO

What do you mean by Mischley being myopic about B1 , B2, B3? 300 mg of thiamine is so low but it’s safe so why so low? That’s too low to even cross the Bbb I think? And 750 of TruNiagin is lower than the trial using 1000. That said, last month I was using 750 TN and 250 regular niacin in the PM.

Regarding being all over every other therapeutic, other than Lithium, I thought she was really standard??

Gcf51 profile image
Gcf51 in reply to

Mischley what does this mean

Gcf51 profile image
Gcf51 in reply to Gcf51

Maybe "Nutty Professor". or Dr. Hide

A simple synopsis for the academically challenged. 3-5 key points or bullets of your Patient Reported Outcome(s) as at Day 14 of your journey.

Gcf51 profile image
Gcf51 in reply to JCRO

I just sent a message to you. I don't know what "Patient Reported Outcome(s)" is

Well. You’re reporting on what you see happening to you after taking what you say you’re taking. That’s Patient Reported Outcomes. Not a Neuro or medical team administering potential therapeutics or placebo and measuring the effects under say the UPDRS and other rating scales or systems. Sorry if that wasn’t clear.

Gcf51 profile image
Gcf51 in reply to JCRO

It's too early not to rule out Placebo.

Because External Links are going to page “Not Found” I am adding up dates to: BAD LINK: healthunlocked.com/cure-par... This Link takes you Page not Found,

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