Quite an interesting article. Thoughts?

[1953bullard]

prnewswire.com/news-release...

[kaypeeoh]

So he's saying there is too much dopamine, not a deficiency. That kinda makes sense in the allergy model. If you're allergic to ragweed the doctor can inject ragweed extract. The injection floods the body with so much that the allergen can't attach to the cell wall. They're bunching up trying but are failing to attach because there's too much of it. Teachers used the hand-and-glove analogy. The cell wall has attachment sites that are like a glove. The allergen is a hand that can fit to the glove. Once it attaches that sends signals to make and secrete histamine. Which is why you take antihistamines.

However the theory doesn't explain what is causing the excess dopamine.

[LAJ12345 in reply to kaypeeoh]

My husbands DNA test shows defects in the pathways associated with seratonin and dopamine. Potentially this might cause it to not be broken down properly. I think it explains why he doesn’t do well on SSRI antidepressants anyway. Maybe the same applies to dopamine.

[Hidden]

In ALZ, it has recently been suggested that the amyloid plaques are an immune response to a pathogen. I have yet to seek out any relationship between this and the proliferation of alpha synuclein in PD. This would mean that the plaques and proteins arrive on the scene but are not the source of the problem. Maybe this is also true of the glutamate Excitotoxicity that manifests in GABA astrocytes attached to the dormant dopamine neurons as observed postmortem in PD. Too much dopamine though typically manifests in schizophrenia.

Our search for answers should expand beyond dopamine. Dopamine is a small percentage of the neurotransmitters in our brain.

Glutamate/glycine should be researched more.

And Acetyl choline.

[Gcf51]

It speaks of toxicity of dopamine, I have Googled in every way I can think of, and I have not found toxic side effects of too much dopamine in the body or gut. I believe you really don’t want excess dopamine in your system. Excessive l-dopa converted to dopamine is probably the reason for of dyskinesia and constipation.

[Hidden in reply to Gcf51]

Schizophrenia is believed to be caused by an excess of dopamine

[Gcf51 in reply to Hidden]

My search was intended to find dopamine toxicity effects in body and gut. I am thinking involuntary movements are caused by excess dopamine. Ok, a thought not associated with the post...

I grew up on a farm and recall my uncle killing chickens and seeing chickens run around and flop around for a few minutes without a head. Movements with no connection to a brain. Maybe, a better example is a snake you can chop off a snake's head, come back 20 minutes later and the body will still be moving.

[Michel0220]

Thank you very much for your post Bullard. I will have the pleasure of interviewing the author of this research publication next Monday the 21st at 7:30 pm London time. Please use the link below for a free registration:eventbrite.co.uk/e/26296819...

[JohnPepper]

May I ask you whether the excess dopamine mentioj=ned in the study was the result of medicaytion?

I don't take any Pd medication anymore. I do fast walking which preduces dopamine in the correct are of the brain. I live a normal life, after over 50 years of fist havinf Pd symptoms.

[Despe]

It sure makes sense. At times, my husband doesn't take any meds (second dose),and he feels and acts fine. He doesn't know what on/off is.

[Hidden in reply to Despe]

Despe, would you mind elaborating? When you say it makes sense, can you explain? I’m not sure if I don’t agree or just don’t understand. ☺️

[Despe in reply to Hidden]

Makes sense, I mean I agree with Dr Sackner-Bernstein's findings. I gave you a personal experience with my husband in my post above.

Another example: Today, he took Sinemet at 9:00 am (has to wait at least an hour after his first medication (Thyroid). He left home 1:00 to go shopping. He called me at 3:00 to pass on info on specific items that I asked him to bring home. He sounded so normal that I forgot he has PD. Came home about 4:00 without having any meds since 9:00 am. His mind was just as sharp as before PD. At 4:30, he took a Dopaboost and up to now, 6:40 pm, that is all the PD "med" he has taken.

As his MDS at Vanderbilt told us "Less (med) is more!" It makes sense to me even more now.

[Despe in reply to Hidden]

PS. Could it be the Ambroxol?