Found this article on CBS

[pdpatient]

Doctors stumped on why there's a trend of younger people diagnosed with Parkinson's disease

cbsnews.com/philadelphia/ne...

[SilentEchoes]

Parkinson's Disease is a toxic syndrome. It's an environmental illness caused by subacute poisoning. It's not just PD either, young people (teenagers) are being diagnosed with ALS and MS too. "Research shows there's been a 50% increase in Parkinson's cases over five years, many patients are under age 50."

50% in 5 years, this statistic is alarming and is a wakeup call for all of us to take action. Future generations are going to be decimated by chronic and fatal illnesses if we, as the ones who go before, don't act.

[WinnieThePoo in reply to SilentEchoes]

You are sure it's a toxic syndrome? Can you describe a mechanism of action for the disease process? You are sure it's not diet? Or stress?Of course you are sure. But unlikely to offer a viable solution to share. Meanwhile, those less blinkered research solutions on our behalf, for which I am grateful

[kevowpd in reply to WinnieThePoo]

She's sure that what she has concluded happened to her is the same thing that happened to everyone even though by her own admission she doesn't have PD. Makes perfect sense.

[curlscurls in reply to WinnieThePoo]

All of those have shifted dramatically in the last 40 years.

[WinnieThePoo in reply to curlscurls]

You mean toxins, stress and diet have changed dramatically in the last 40 years. But that wasn't SilentEchoes point. She asserts PD is a toxic syndrome. It is caused by toxins. Exclusively. Without an explanation of how 99% of the population, exposed to the same toxins (and diet , and stress) don't get the disease.

Of course if you jump to conclusions which suit your preconceived mantra, you fail to appreciate the real cause of the 50% "jump"

The research mentioned in the article is not referenced, but do you think it might be this ?

"A 2022 Parkinson’s Foundation-backed study revealed that nearly 90,000 people are diagnosed with Parkinson’s disease in the U.S. each year. This represents a steep 50% increase from the previously estimated rate of 60,000 diagnoses annually."

(I think it very likely)

So we have lies, damn lies, and statistics to blame - not toxins or diet (but maybe an ageing population due to improved healthcare and much reduced casualties of war post 1945.

In the first place the previous research, 40 years ago, from which this "increase" has occurred was - well, flaky

"the previous prevalence study, conducted 40 years ago, extrapolated the 26 people with PD in a rural Mississippi county as a benchmark estimate for PD prevalence in the U.S."

So the 50% dramatic increase over 40 years is primarily due to the original number being a bit of a joke.

It's also worth reading the new studies conclusions, before rushing the toxin " I told you so"

"The study, titled "Incidence of Parkinson Disease in North America ," found that:

PD incidence estimates increase with age in the 65+ range.

The primary risk factor for PD is age.

PD incidence estimates are higher in males as compared to females at all ages.

The increase in the incidence of PD aligns with the growth of an aging population."

[SilentEchoes in reply to WinnieThePoo]

Genes load the gun, environment pulls the trigger. There are common gene mutations that make some people more vulnerable to toxic exposures. I didn't define toxin - you did. Bacteria, viruses, drugs, and pesticides that I group as poisons, use the same biological pathways to cause illness. Your genes influence how the toxic exposure expresses itself. Some genetic mutations are MTHFR, PON and ATP13A2.

Without my acute exposure I would not have gotten ALS. I was more vulnerable to injury because of my genetic makeup. My mother's exposure was related to her occupation as a hairdresser, and insecticide use in the house. These were low level exposures over time and she got PD. There is no family history of PD or ALS.

ATP13A2 is called PARK9. I inherited this from my mother. It's a missense mutation and I only have one copy of the gene.

PD - nature.com/articles/s41467-....

ALS- humgenomics.biomedcentral.c...

ATP13A2 is not considered one of the genes that causes ALS. It's a risk factor that requires a trigger.

The underlying mechanism of PD is not well defined, however, both genetic and environmental causes contribute to it. The promoter region of the human ATP13A2 gene contains hypoxia response elements which can bind to transcription factor hypoxia-inducible factor 1α (HIF-1α). Hypoxia up-regulated ATP13A2 transcription via HIF-1α in HEK293 and dopaminergic MN9D cells. Our study indicates that hypoxia signaling plays a very important role in the regulation of human ATP13A2 gene expression. pubmed.ncbi.nlm.nih.gov/222...

Hypoxia (exposure to asphyxiants like carbon monoxide and cyanide) triggers the dysregulation of ATP13A2, which as the name suggests is involved with ATP mitochondrial energy production.

Organophosphates contain cyanide.

[Edge999 in reply to WinnieThePoo]

It’s sugar….

[MBAnderson]

"Doctors stumped on why..." but, I know. There are more toxins in the environment. Hello?

[SilentEchoes in reply to MBAnderson]

They're not stumped, they're beholden to the pharma/medico complex.

Our funding isn't at risk - our lives our.

[CuriousMe12 in reply to SilentEchoes]

Silent It looks like the Gang have picked on you today to vent their keyboard aggressions.I'm not sure you meant that all PD was caused by toxins as there will be other causes. However I do agree there is a high incidence among certain groups working with chemicals e.g. dry cleaners, farmers...

And the stats of the report do show incidence is 50% up, whatever the reason.

[WinnieThePoo in reply to CuriousMe12]

"the previous prevalence study, conducted 40 years ago, extrapolated the 26 people with PD in a rural Mississippi county as a benchmark estimate for PD prevalence in the U.S."Read that a couple of times. And then a 3rd. For 40 years the figure for prevalence in the USA was based on extrapolating 26 people in one rural Mississipi county.

And now they've done a survey of thousands of people across the USA, when life expectancy is 10 years more than in 1972.

The only thing you can conclude from that is that survey techniques in this field have improved.

26 people. One county. For the whole usa. You couldn't make it up 🤣

[CuriousMe12 in reply to WinnieThePoo]

Two flumuxing points there.1 that they'd produce a 50% increase headline from useless prior comparative data.

2 that countries don't have a central up to date national count of their diagnosed diseases.

[kevowpd]

Research shows there's been a 50% increase in Parkinson's cases over five years

That's crap. Utter crap. There's been an update in the estimates of incidence but that is driven by historically poor data collection. It does not mean a "50% increase in cases". Anyone that thinks cases (in the young or old) have increased 50% in 5 years needs to take a good hard look at their ability to analyse information before going online to be alarmist about it.

There's also nothing in the actual article that attributes this 'stumped' status to an actual doctor.

[cgreg in reply to kevowpd]

My MDS doctor is aware of the severe shortage of trained physicians who can competently diagnose PD. I once asked him about my symptoms and his reply was "a lot of people, including some neurologists, would think you had a stroke because your arms are not swinging". Clearly, it would mean that an increase in the number of competent MDS doctors would also lead to more PD diagnoses.

[curlscurls]

If it's related to chemicals then that's not a mystery. We now have more chemicals we're exposed to earlier.

[LAJ12345]

the first generation of fast foodies coming of age

Side effects from covid or an historical virus

more sedentary/ less manual occupations

Increased numbers people prescribed various medications eg ssri, adhd drugs and others

Effects of wifi affecting mitochondrial function

Effects of various pesticides

Effects of mercury amalgams

First generation to have too much food

Ultra insulated and airtight houses increasing hidden mould

Use of modern building materials.

Exposure to new industrial processes,

Greater exposure to petrol and diesel emissions

Plenty of possibilities.

[Manypony]

I call it JENGA! All of the above, and likely more….

[bassofspades]

no, no, no. all that stuff is safe, they tell us that all the time. Its probably that theyre getting better at testing and diagnosing the disease.

[gomelgo]

so much "no but" ... what about some more "yes, and"?