Was waiting to see if anyone posted but nobody did yet. This seems to me something more than a tenuous prospective link and would be interested in critical thoughts.
Gut Inflammation Linked to Brain Disease Onset in Preclinical Study parkinsonsnewstoday.com/202...
Hi Marion,
This paper was previously published on BioRxiv in 2019, under the title "Experimental colitis drives enteric alpha-synuclein accumulation and Parkinson-like brain pathology".
In the interim, four more-recent papers have cited the 2019 version.
Grathwohl: Experimental colitis drives enteric alpha-synu... - Google Scholar
scholar.google.com.au/schol...
I'm not sure how helpful this information is, but I'll leave that up to you.
Jeff
See also the following 2019 AlzForum article, which includes some discussion the 2019 version of the research paper.
Do Immune Cells Promote the Spread of α-Synuclein Pathology?
This is very interesting. My husband had a bleeding colon in which he lost about half of his blood. He was diagnosed with IBS and colitis after that in 2015. He was just diagnosed with Parkinson’s June 2020. We had been thinking he has had Parkinson’s since 2016. So this is a very interesting article. Thank you for sharing.
Yes, I would believe this. My husband definitely had some kind of gut problem and also skin problems with acne and rosacea as long as I’ve known him. After changing diet and treating with berberine and Allimed (allicin) and alternating with probiotics for over a year his rosacea finally left along with his Parkinson’s smell which indicates to me there is a gut connection. His swollen belly has flattened out too and he has lost his extra weight.
I have had facial skin issues as well as my recent PD diagnosis. I have noticed a change in my skin issues by removing almost all dairy and going more vegan. I eat way less red meat and try to avoid processed foods. Its a bit tough at times but with noticeable results its worth the struggle. I also belive they are all linked.
They are the same diet changes we made. And eliminated sugar and most seed oils and gluten.
So remove dairy, sugar, gluten and seed oils(??)
And go more vegan
We do meat night, vege night, fish night, Vege night in rotation.Vege night might be vegan like tonight we had potato, pea and cauliflower Indian curry with rice. Or it might be say eggs in quiche or omelette. Or chilli beans, or paneer curry or Vege curry with peanut in sauce.
We eat lots of Vege or salad on the meat and fish night too.
Also remove additives so only eat things that aren’t processed except say tomato purée, frozen peas, canned fish with no additives.
Use olive oil, butter, coconut oil. No soya oil, canola oil, margarine, sunflower oil.
Also uses digestive enzymes - NOW super enzymes, and takes NOW pantethine double strength to help oil and fat digestion.
No constipation, acne and rosacea gone and Parkinson’s smell gone🙂
Great. Will try to incorporate. Thank you Laj
When I cut back on the dairy I noticed my skin issues cleared way up. Next was going more vegan for the fiber and benefits to my colon health/ gut biome. Now I still eat meat, just cut it way back, and almost no red meat. You should look into it even just having more vegan meals. Since I have also made these changes I have started loosing weight and feeling better. Indian food is great,.because of the turmeric and peppers. Also many of their spices are beneficial. I have a friend who has kidney issues and since she has gone full vegan her issues have all but gone.. I also know a guy who went full vegan, lost 180lbs and his blood test are completely back to normal. Its all about life style choices, we have to take care of ourselves.
Thanks for sharing
This is very interesting to me. No one in my family has ever had Parkinson's Disease (that I know of). The environment can be a culprit, but I have no idea how that would have caused me to have PD. I've been reading more and more about the connection between the gut and brain. I did have what was called a "non-specific colitis" for many years. I had pain and diarrhea then "something happened" about 25 years ago and I went in the other direction and I became seriously constipated. I was diagnosed with PD in 2014. I have many non-motor symptoms, cognitive, as well as loss of smell and taste. If anyone can direct me to other articles/studies I would appreciate it.
Here is an article that may be of interest - Altered Gut Microbiome and Intestinal Pathology in Parkinson’s Disease (Journal of Movement Disorders)
ncbi.nlm.nih.gov/pmc/articl...
“Recent advances in understanding the gut–brain axis have linked microbiota and intestinal pathology to PD pathogenesis.
Based on animal and clinical studies, changes in the composition of the gut microbiota are proposed to induce a pro-inflammatory response in the gut. According to this conceptualization, the inflammatory response increases gut permeability and exposure to endotoxins or other bacterial products and induces α-synuclein aggregations, which in turn propagate to the CNS via the vagus nerve.
In addition, a systemic inflammatory response might disrupt the blood–brain barrier, which, in combination with α-synuclein delivery from the gut, further activates microglia and results in dopamine neuron degeneration….”
Thank you.
CI,
In the 2020 and 2021 FMT/PwP study results, they essentially offer a bit of confirmation to this whole idea. Patients with symptoms and gut dysbiosis, rebalanced their gut microbiota via FMT and shifted their gut microbiota from excess pathogenic bacteria toward more health promoting bacteria and constipation and SIBO were very significantly reduced while motor and non motor symptoms were significantly reduced steadily over the 12 week study period. Test score reductions for motor and non motor symptoms were reduced by about 40% in the 2020 study and by 50% or greater in the 2021 study.
These are very impressive results in actual PwP!
healthunlocked.com/cure-par...
Art
"SIBO" ??
Small Intestinal Bacterial Overgrowth = SIBO. This is common in PD varying between 25% to 50%+, depending on the study referenced.
pubmed.ncbi.nlm.nih.gov/246...
gutpathogens.biomedcentral....
parkinson.org/blog/tips/non...
Art
So would probiotics and prebiotic be worth taking? Also what type of diet would help? I take both as well as Cinnamon and have gone more vegan to benefit my colon flora. I have read many articles all talking about gut biome and a. PD link.
This kind of relates to the FMT posts. Fix your microbiome fix your health.
What i have done since I was diagnosed with REBSBD Apr 2nd is change my diet to the Wahls Paleo Plus protocol, which is a popular auto immune diet and is keto (which should help with PK), and I have combined it with the Specific Carbohydrate Diet (SCD).
By combine I mean I only eat foods that are approved for both diets.
There is good evidence that the SCD normalizes the microbiome:
The Specific Carbohydrate Diet and Diet Modification as Induction Therapy for Pediatric Crohn's Disease: A Randomized Diet Controlled Trial
pubmed.ncbi.nlm.nih.gov/332...
Here is a good link to the SCD: breakingtheviciouscycle.inf...
And here is the Wahls Paleo Plus food list: elmmedicine.ca/wp-content/u...
Bolt
This is a really interesting and well made video about the gut mucosa x
Like Champman, I also have Crohn's disease, and was diagnosed with it decades before my PD. So I do believe in the gut to vagus nerve to brain connection (just as the Chinese have for centuries) - "Over the course of the 10 month experiment, the researchers saw evidence that the alpha-synuclein began building where the vagus nerve connected to the gut and continued to spread through all parts of the brain."
sciencebeta.com/parkinsons-...
Which of course is why I take Ambroxol, to address this alpha-synuclein aggregation in the brain now that it's there. Short of cutting the vagus nerve to prevent transmission (a vagatomy) which appears to materially lower the risk of getting PD scienceofparkinsons.com/tag..., and now that we already have PD, yes a probiotic could be helpful, solace is one of note: parkinsonsnewstoday.com/202...
Hi MarionP , you might find the information in these videos interesting, go to gutsolutionseries.com . All the best
An Australian company Symbyx sells a light device that treats the gut biome.
Parkinson's: Dietary compound moves toxic protein from gut to brain
Study links Glyphosate in Roundup to Neurodegenerative Disease 
The Gut-Brain Connection: How it Works and The Role of Nutrition; Explained in layman's language as per Healthline
Informative article with links re PD and Gut microbiome
LL-37, a natural antimicrobial molecule present in the brain and gut, Suppresses Alpha-synuclein Clumping in Parkinson’s
