Is there any treatment for PSP

[Webber1]

What are the best treatments for PSP

[PixelPaul]

Sadly there are none. Levodopa typically is far less effective (if at all) for the "atypical" or "parkinson's plus" conditions.

[jeeves19]

It’s a truly rotten disease. I watched my wife nurse her mother through it. The only thing that might work from what I have deduced is fasting which might encourage the brain to clean up some of the debris and rogue proteins that aggregate together and cause so much damage.

[chartist]

Webber1,

Although PSP and PD are different from each other, they both have a perturbed gut microbiome in common.

pubmed.ncbi.nlm.nih.gov/305...

In the 2020 and 2021 Fecal Microbiota Transplantation (FMT)/ PD studies, FMT was able to reduce test scores by 50% or greater and in turn reduced gut health issues SIBO and constipation as well as non motor and motor symptoms significantly while shifting the gut microbiota back toward less pathogenic bacteria while increasing health promoting bacteria that was similar to those seen in healthy controls. I wrote about it here :

healthunlocked.com/cure-par...

To extend this information a step further toward non-FMT treatment, read the post I put up today :

healthunlocked.com/cure-par...

The point being that since there aren't effective treatments for PSP or MSA, this may be an option worth considering.

Art

[sharoncrayn in reply to chartist]

drawing a conclusion from n= 22 psp? (Epub 2018 Dec 21.

Unraveling gut microbiota in Parkinson's disease and atypical parkinsonism )

[chartist in reply to sharoncrayn]

That was not a conclusion, that was an idea to consider out of all of the many other options for PSP. What was that number of other options again?

Art

[sharoncrayn in reply to chartist]

Chartist,

from your citation: "Although several studies have suggested that abnormalities in gut microbiota may play a critical role in the pathogenesis of PD, data are still extremely heterogeneous. " Sums it up IMO.

Chartist asked: "What was that number of other options again?"

Answer: none

Right now, I don't think FMT is an option for most PSP 1) given you would want to go to Mayo , and 2) evidence is very scarce for human PD let alone PSP effectiveness (but excellent for CDI regardless of the route for administration). PSP is not related in my mind to CDI, which is related to aging, diet, and lifestyle(no exercise) as is constipation.

Nor do I think any other "options" exist for PSP and its subtypes, at least valid ones that work.

PSP? The clinical heterogeneity is associated (in PSP) with variability of regional distribution and "severity" of abnormal tau accumulation and neuronal loss. No easy answers, or options.

Read Boxer: "There are currently no effective treatments for PSP, but because PSP is strongly linked biochemically and genetically to tau protein abnormalities, there is a growing interest in pursuing clinical trials of new tau-directed therapies for this disorder. " Boxer 2017 New diagnostics and therapeutics for progressive supranuclear palsy

TAU BASED CTs EXIST, BUT ARE ORIENTED TO ALZ....why? because Age-adjusted progressive supranuclear palsy prevalence was 2.95/100,000 in 2016.

Sharon

[LostinHeadSpace]

Webber, there's a specific PSP group on Health Unlocked, with lovely people focusing just on that. Best to you!

[condor39]

Webber1. There are lots of treatments, and most cases respond to them very well. Your question is not answerable - you need to educate yourself, and get your advice from a neurologist , and preferably one who is a Movement Disorder specialist - not from a website. !