PK protocol

[akgirlsrock]

Patricia Kane protocol

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The Patricia Kane protocol (PK protocol) is an experimental treatment for neurological disease involving intravenous infusion of phospholipids and methylation factors, along with dietary changes and supplements.

It is based on the theory that in diseases Kane classes as those of neurotoxicity (e.g., multiple sclerosis, Parkinson's, Chronic Fatigue Syndrome), toxins destabilize cell membranes leading to dysfunctions in cell signaling and homeostasis and neurodegeneration.

Contents

1Theory

2Protocol

3Medical applications

4Evidence

4.1Sodium phenylbutyrate

5See also

6References

Theory

She seeks to correct deficiencies of Omega-6 and arachidonic acid in cell membranes and correct the over-expression of very long chain fatty acids.

Protocol

The protocol is individualized but involves several key components: intravenous infusion of phosphatidylcholine and sodium phenylbutyrate, pushes of glutathione and folinic acid, methylcobalamin injections, and increased intake of essentially fatty acids.

Patricia Kane recommends elimination of all processed foods, especially those containing Omega-6 oils, regular intake of pastured eggs, and a "cell membrane stabilizing drink" consisting of liquid phosphatidylcholine, evening primrose oil, whey protein, and a blend of safflower and flax seed oil in a 4:1 ratio of Omega-6 to Omega-3, and a blend of seeds. She also recommends a low carbohydrate, high fat diet.

Medical applications

Kane believes her protocol can offer clinical benefit in a range of neurological disorders including ALS, Parkinson's Disease, Multiple Sclerosis, Alzheimer's, Autism, pervasive developmental delay, seizure disorders, Post Stroke, traumatic brain injury, metabolic and genetic abnormalities.

Evidence

There have been no clinical trials of the PK protocol for the treatment of any disease.

Some of the individual components of the protocol have been studied.

Sodium phenylbutyrate

In mouse models of Parkinson's, sodium phenylbutyrate was found to protect the loss of dopaminergic neurons.[1][2][3]

See also

Omega 3 fatty acid hypothesis

References

ncbi.nlm.nih.gov/pmc/articl...

jbc.org/content/286/17/1494...

journals.plos.org/plosone/a...

The information provided at this site is not intended to diagnose or treat any illness.

From MEpedia, a crowd-sourced encyclopedia of ME and CFS science and history

Categories: Medical hypothesesProtocols

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This page was last edited on 24 April 2019, at 15:38.

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[SilentEchoes]

THANKS!!!!!!

[condor39]

NO trials? No evidence? Why is our Time being wasted with this nonsense theory?

[PDDBSwife]

My husband (PD x 20+) and I went to Patricia Kane's [then] Philly clinic back in 2001 and spent a fortune on her 'protocol'. I clearly remember seeing ALS patients on their last legs and a prematurely aged mother of a grown son with severe autism. They didn't get better either. We spent a couple months there and hubby just got worse. Her theory of long chains of fatty acids blocking receptors being 'purged' by her phosphatidylcholine and glutathione pushes was the sort of thing that led me to write about 'snake oil' much later. It's that smidgeon of validity that sells. I am appalled and saddened to see her theory being revived.

[akgirlsrock]

Thank you