Experiences with

Alzheimer's disease

https://www.google.com/amp/s/newsroom.clevelandclinic.org/2021/12/06/cleveland-clinic-research-identifies-sildenafil-as-candidate-drug-for-alzheimers-disease/amp/

Reduced risk of incident #Alzheimers disease in 15,820 people with #T2D randomized to GLP-1R agonists in clinical trials and in Danish registry data https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/trc2.12268

https://fortune.com/longform/alzheimers-disease-cure-breakthrough/amp/

A 2021 study suggests that sildenafil (Viagra, Revatio), which is used to treat erectile dysfunction and pulmonary arterial hypertension, might also protect against Alzheimers disease: https://www.health.harvard.edu/mens-health/erectile-dysfunction-drug-may-lower-alzheimers-risk?

Is Alzheimer’s Disease a Liver Disease of the Brain? 2020 https://content.iospress.com/articles/journal-of-alzheimers-disease/jad190848 If Alzheimer’s Disease can be caused by the liver, well maybe PD can too.

The article is: https://www.aftau.org/news_item/hyperbaric-oxygen-therapy-reverses-hallmarks-of-alzheimers-disease-and-dementia/ This is the full strength version of the article: https://www.aging-us.com/article/203485 Appreciate feedback from the wonderful members of this amazing group.

https://scienceofparkinsons.com/2022/04/13/b1/ Please excuse if it's been already posted. Also talks about Alzheimer's, benfotiamine. Interesting.

Although this study is about Alzheimer's Disease (AD), it is very interesting in showing how the gut microbiota can be manipulated to very good effect and that fact is very important for many diseases including PD. It is also worth noting that some of the methods of action that have so far been discovered

L-Tryptophan metabolism through the kynurenine pathway is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in tryptophan metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the kynurenine

AMX0035 is a drug combination of sodium phenylbutyrate (PB) and tauroursodeoxycholic acid (TUDCA). It works by regulating the mitochondrial (cell power supply) and endoplasmic reticulum (quality control centers). Put simply, both processes should work in unison, but when they don’t, cells in the body

I've watched several interviews with biochemist Dayan Goodenowe PhD (https://drgoodenowe.com/) where he discussed increasing plasmalogen levels to prevent Alzheimer's and other dementias. He mentioned that higher plasmalogen levels also help in Parkinson's by improving function in dopaminergic neurons

https://irpages2.eqs.com/websites/annovis/English/431010/us-press-release.html?releaseID=111474&d=202201250900 The U.S. Food and Drug Administration (FDA) has given positive feedback to Annovis Bio’s plans to start two Phase 3 clinical trials of buntanetap (ANVS401) as an oral therapy for early- and

The Potential Utility of Prebiotics to Modulate Alzheimer’s Disease: A Review of the Evidence 2021 https://www.mdpi.com/2076-2607/9/11/2310/htm 6. Concluding Remarks Although human clinical studies examining the effects of specific prebiotics on gut microbiome-mediated cognitive health outcomes in AD

https://parkinsonsnewstoday.com/forums/forums/reply/20641/ The concept that Parkinson’s disease is essentially a vascular dysfunction disorder comes from the pioneering work of Dr. Berislav Zlokovic and his research team at the Keck School of Medicine at the University of Southern California. These USC

You don't need a niacin prescription either. https://www.mdlinx.com/news/researchers-discover-intake-of-fda-approved-drug-modulates-disease-progression-in-alzheimers-disease/76FINpPCpzJfueriPH2eRN?

https://medicaldialogues.in/amp/neurology-neurosurgery/news/mind-diet-associated-with-better-cognitive-functioning-in-elderly-study-82227 Aging takes a toll on the body and on the mind. The neurodegeneration menifests in form of tissue of aging human brains sometimes developing abnormal clumps of proteins

There is a whole lot more information in this 2018 paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5734125/ Here is one more amazing story about LMTM: https://content.iospress.com/articles/journal-of-alzheimers-disease/jad210390

I'm excited by the results being reported by Bredesen and other doctors he's trained. Results mean a LOT when it comes to complex brain disfunction (such as Parkinson's and Alzheimer's), and he's getting them! My goal here is to start a discussion, explore what he's doing in his "protocol", and how

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson’s disease: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8116202/ Neuroregulatory role of ginkgolides: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8338821/ Vinpocetine Biloba Stack: https://www.braintropic.com/nootropics/vinpocetine

A very interesting and well done study out of NYU. While focusing on ALZ, it obviously has ramifications across all neurodegenerative diseases, such as PD. In many respects this answers the question that many PwP had regarding infection from Covid-19 or its variants. COVID-19 Infection Associated with