DL‑3‑n‑butylphthalide therapy for Parkinson's disease: A randomized controlled trial

[Farooqji]

Currently available treatments for Parkinson's disease (PD) do not delay or prevent disease development and progression. DL‑3‑n‑butylphthalide (NBP), isolated from Apium graveolens seeds, alleviates oxidative damage and mitochondrial dysfunction. It has been revealed to reduce the loss of dopamine neurons in pre‑clinical PD models, and has been approved for the treatment of ischemic stroke patients. The purpose of the present study was to examine whether NBP has the capacity provide a benefit for PD patients and to slow disease progression

spandidos-publications.com/...

[park_bear]

Thank you for finding this important piece of research. The active ingredient is actually a component of celery seed extract which can be purchased online. They found a significant improvement in treated patients, versus placebo patients who declined. I am planning on doing a separate post to make sure this comes to everybody's attention.

Kudos to the publisher who is making the full study available for no charge.

[Jjrr]

This sentence in their journal article concerns me (does not seem to be a truly blind study): "The patients knew their treatment assignment, but did not know the study hypothesis."

I am also confused that the graph of the tremor score (Figure 3B) does not appear to match the values listed in Table II -> unless i am reading things wrong, this seems like an error in the paper.