Findings
A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy.
Link:
sciencedirect.com/science/a...
" INTRODUCTION Citicoline or cytidine-5’-diphosphocholine is a natural precursor of phospholipid synthesis, chiefly phosphatidylcholine, and serves as a source of choline in the metabolic pathways for biosynthesis of acetylcholine in the body.1"
I mix lecithin with MCT Oil and use in place of butter:
healthunlocked.com/cure-par...
sciencedirect.com/topics/ne...
"Lecithin (phosphatidylcholine) is a precursor for choline. As such, it is involved in the synthesis of the neurotransmitter acetylcholine, and levels of lecithin correlate with levels of choline and acetylcholine. ... Thus, supplementation with lecithin apparently stabilizes the membrane and changes action potential."
healthunlocked.com/cure-par...
Thanks for reminding me. I just read through all of those posts. Does not look worth adding to my stack.
I recommend looking in to what is said about Citicoline for ALZ. At present, LBD is addressed in much the same way as ALZ. Until there is better research, that’s all we’ve got. As I’ve mentioned before, Dr. Dale Bredeson is a good source for this.
Why not try? It just might give you some relief
Thanks JayPwP, I have not been diagnosed with PD (although I do have a tight left shoulder. Praying it is mouse shoulder from 20 years of 12 hour days using a mouse). I have REM Sleep Behavior Disorder (my doctor says pre-PD). So my symptoms are just the occasional outburst in my sleep, and a sore left shoulder and arm.
Now is Citicoline can stop progression, that would be sweet. I'd like to get down to just a few supplements. I put the most trust in Niacin and B1 so far. But will be adding B12 soon. And I trust Zeolite will do good things for me over time.
So you are doing both the B1 thiamine HCl and the niacin B3 protocol together?
I'm doing B1 1000 mg around noon.
Niacin 250 mg Time Released before bed with 10 mg of Melatonin.
1000 mg of Taurine, 1200 mg of NAC and 1000 mg of Glycine about an hour before bed.
750 mg of Inositol and 100 mcg of Selenium (to lower my thyroid anti-bodies).
Curcumin, butyric acid, Magnesioum l-threonate and Lion's Mane twice a day.
And 9 grams of Zeolite Cliniptilolite in water in the morning to clean out metals, toxins and pathogens.
I have a High School degree. Please nobody be under the impression I know what I am doing.
My understanding is that Dr. Mischley uses Citicoline to help patients reduce their dose of C/L if the C/L dose level is causing problems like dyskinesia. From what I remember she said it takes around a month to take effect, and that the sign that you're ready to reduce C/L is increased dyskinesia. So she uses this when patients get to the point that C/L dose is causing problems, which as I remember is going over 200 mg of levodopa per dose for many patients.
mdpi.com/2072-6643/12/10/31...
Recent survey article of research on Citicoline for different brain diseases:
Conclusion: "This systematic review showed that citicoline has a wide range of uses in neurological conditions. In dementia, it is useful primarily in inhibiting disease progression, and, according to the results of some studies, reversing adverse changes. Citicoline also improved memory and other cognitive functions among healthy volunteers. For this purpose, they were assessed with various tests, which adds credibility to these studies. Citicoline has also been shown to be a promising drug in reducing neuropathic pain and accelerating nerve regeneration. Unfortunately, these studies were only conducted in animal models. Citicoline may prove to be a potentially beneficial adjunct in the treatment of stroke. However, citicoline has unclear effects in the treatment of brain injuries. Citicoline, depending on its application, can be considered both as a dietary supplement and as a medicine. Further research on this substance should be carried out, including other neurological and non-neurological diseases."
Personally, I'd wait until my C/L dose is causing me problems to add this, but it does have additional benefits besides lowering C/L dose, so I would add if needed.
Jarrow has a product that would cost between $30-$40 per month, depending on how much you need to get the desired effect.
This looks interesting: "In dementia, it is useful primarily in inhibiting disease progression, and, according to the results of some studies, reversing adverse changes"
Where did you find that please?
Copy and paste the link 
This is a link to your local C drive:
file:///C:/Users/Lotus/Downloads/nutrients-12-03113-v2%20(1).pdf
sorry, you're right. Let me look for it...
And thanks for sharing the detail of the timeline. It is important to remember these things take time.
I started Citicholine a week ago, and I feel good, legs are not as week, I can get up from sofa now.
Thanks for sharing LauraYu. I'm glad it is helping.
What dosage are you using please?
I am just on 250 mg per day. I also take a small dose of B complex( a full spectrum B). The first benefit I noticed is slightly improved balance, followed by reduced leg weakness. I did some research, apparently citicholine impacts many neurotransmitters, including dopamine
how r you doing now? Which brand of Citicoline you’d recommend?
I stopped citicholine supplements. It brings benefits, but also made my dyskinesia worse, up to a point that I couldn’t tolerate. I can’t afford to give up on taking Sinemet
Did you reduce your dose of Sinemet when taking Citicoline? People have reported reducing their Sinemet by up to 50% when adding Citicoline. Too much dopamine can increase dyskinesia. Citicoline has levodopa sparing effects as it increases dopamine in the brain.
pubmed.ncbi.nlm.nih.gov/332....
A relevant quote the systematic review of Citicoline studies :
' Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy. '
naturalmedicinejournal.com/...
A relevant quote :
' Levodopa is often used in the long-term management of Parkinson’s disease; however, prolonged use of levodopa is marked by a progressive decrease in efficacy and the development of dyskinesia and other side effects, which often occur after about 3 years of treatment. Citicoline has been found to have a levodopa-sparing effect and an ability to increase dopamine synthesis. This nutrient was studied in a trial in which 85 Parkinson’s disease patients were randomly assigned to 2 groups: patients were to receive either their usual dose of levodopa (mean 381 mg/day) or half their usual dose (mean 196 mg/day); both groups were simultaneously administered 1,200 mg citicoline (as 400 mg by mouth, 3 times/day). The Webster Rating Scale, a measure of neurologic and clinical symptoms, showed no significant changes in either group. A drawing test was used to evaluate degree of tremor. In the group taking the full levodopa dose plus citicoline, there were no significant changes on this test. However, in the group consuming half of their usual levodopa dose plus citicoline, significant improvements were noted at week 6 (which was the end of the 4th week of citicoline administration).
If you took Citicoline and did not reduce levodopa, there is a good chance that the increased dopamine caused by Citicoline in conjunction with the increased dopamine caused by levodopa could have been the cause for increased dyskinesia via too much dopamine.
There is also the possibility that the levodopa sparing effects of Citicoline may potentially extend the useful life of levodopa products such as Sinemet over your lifetime.
One question regarding Citicoline, what benefit did you notice before the dyskinesia made it impossible to continue using it?
Art
no, I didn’t adjust my sinemet dosage. I was expecting longer sinemet on-time if dopamine was higher, which wasn’t the case. I did see some improvements when I was on citicholine, my balance was slightly better and my leg weakness was also improving
Thank you for your reply, and wish you and your family a Very Merry Christmas!
I reread everything I could find and was just not convinced. Will keep coming back to this to review. Ordered some Vinpocetine.
Transcranial magnetic stimulation improves cognition over time in Parkinson's disease September 2019UM-Palmitoylethanolamide can slow down Parkinson's disease 2017
Anavex Life Sciences achieves statistical significance for potential disease modifying therapy for Parkinson's Disease.
MRgFUS Pallidothalamic Tractotomy for Chronic Therapy-Resistant Parkinson's Disease in 51 Consecutive Patients: Single Center Experience
Is Parkinson's disease a lifestyle disease? 1. Parkinsonian lifestyle (higher risk).
