trying to consolidate b6 facts

[Jmellano]

my neuro wants to watch my b6 levels and I am trying to glean what I can about b6 in this website.

please correct me if I am wrong or add to this post as you see fit

1. There are 2 types of b6, pyroxidine and P5P

2. Too much pyroxidine can be toxic and may lead to neuropathy

3. Too much b6, either form , can react poorly with levodopa

4. Too much p5p is not toxic and one cannot OD if taking P5P

I am so confused…

[park_bear]

Correcting item 3: B6, in either form, cannot be taken at the same time as C/L because they will inactivate each other.

Item 4: Some people do have trouble with large quantities of P5P, Others, such as myself, are fine with it.

In addition to the foregoing, it is important to be sure you have adequate levels of vitamin B2, riboflavin. Deficiency may cause buildup of pyridoxine.

[Jmellano in reply to park_bear]

@park_bear thnx much. PD is such a complicated disease...

[gaga1958 in reply to park_bear]

could you again remind how much time in between B6 and C/L to not cancel each other out. Thxs

[park_bear in reply to gaga1958]

Separate by 2 hours if possible, if not possible separate by a meal.

[Caro-1973]

You can take 10 to 25 mg per Day without problems. Perhaps 30mg. Without b6, levodopa do not converts in dopamine.

[Esperanto in reply to Caro-1973]

In all the test results I have received for my database, there are too high levels of B6 when supplementing with more than 5 mg of P5P or pyridoxine, as well as at high intake of carbidopa/levodopa. While a B6 overdose may be harmless for some individuals, it can be very harmful for others. It can affect both your PD symptoms and the possibility of developing PN, peripheral neuropathy. Taking this risk may not be advisable. It is best to first have your B6 levels tested and continue to monitor them regularly if you are taking higher doses. Otherwise, it would be advisable to stick to a mild B-complex supplement with lower doses of each B-vitamin to meet the recommended 100% daily intake (ADI) for each vitamin. All B-vitamins are interdependent, including the production of dopamine.

[Farooqji]

I would strongly recommend NOT to take B6 (any form) unless deficiency is proven in blood test. Remember B6 toxicity is more damaging than B6 deficiency

[Esperanto in reply to Farooqji]

‘Remember B6 toxicity is more damaging than B6 deficiency´ is not true, Farooqi, and even dangerous. A B6 deficiency, which is relatively common in people with Parkinson's is perhaps more serious than an overdose! Strangely enough, it can also lead to peripheral neuropathy, and it can cause your PD medication to be ineffective and worsen your PD condition dramatically. In addition, apart from PD, it is essential for many body functions. I experienced a serious deficit myself after my PD diagnosis, and it's hard to believe that I wouldn't have irreversible severe PN and would likely be symptom-free with a simple low-dose vitamin B-complex pill if my neurologist had continued studying after medical school.

However, your warning about B6 overdose and getting a blood test is also very important. A B6 test is actually a must for everyone with PD, especially for those taking C/L medication!

[Farooqji in reply to Esperanto]

My point has been explained in your reply's last paragraph (in bold font)