Here are several different articles about prebiotic and probiotic(s)
(possibly in combination with each other). And the final article relates
to PwP oral infestation with gram negative bacteria and
aspiration pneumonia.
1) Fenugreek as adjuvant therapy with L-dopa
First of all, Fenugreek has been shown to be good adjuvant therapy with L-dopa:
Efficacy and safety of standardized extract of Trigonella foenum-graecum L seeds
as an adjuvant to L-Dopa in the management of patients with Parkinson
PwP consumed 300 mg of fenugreek capsules twice daily.
"In conclusion, IBHB can be useful adjuvant treatment with L-Dopa in management
of PD patients."
forum.parkinson.org/topic/1...
extract-of-trigonella-foenum-graecum-l-seeds-as-an-adjuvant-to-l-dopa-in-the-
management-of-patients-with-parkinson/
2) Prebiotic + probiotic
Galactomannan from Trigonella foenum‐graecum L. seed: Prebiotic application
and its fermentation by the probiotic Bacillus coagulans strain MTCC 5856
"Galactomannan was extracted from the fenugreek seeds as per the proprietary
method (chemical and enzymatic) of Sabinsa Corporation, USA, by following
current good manufacturing practices (cGMP). This commercial product is sold
under the brand name Fenumannan® which contains minimum 60% of galactomannan."
"The galactomannan was fermented and utilized (71.4%) by the B. coagulans
MTCC 5856, and also significant amount of short‐chain fatty acids production
was also observed."
onlinelibrary.wiley.com/doi...
My previous posting on short chain fatty acids:
healthunlocked.com/parkinso...
fatty-acids-sodium-butyrate-phenylbutyrate
Lactowise = Fenumannan combined with Lactospore (B. coagulans) so both pre and probiotics are combined in the same drink.
ulprospector.com/en/na/Food...
-----------------------------------
A probiotic only:
Probiotic correction of intestinal dysbiosis in Parkinson’s disease
"Constipation is an important non-motor symptom in PD."
"Compared with pre-treatment, NMSS scores decreased from 30.1±11.0 to 17.3±5.4
(p<0.01), defecation frequency increased from 1.8±0.6 to 3.7±1.1 per week
(p<0.01)."
"Conclusions: PD accompanied with the development of intestinal dysbiosis.
The introduction of probiotics (E. faecium L3) may contribute to correction of
microbiota imbalance and reduce manifestations of dyspepsia and constipation."
mdsabstracts.org/abstrcact/...
-dysbiosis-in-parkinsons-disease/
------------------------------------
Probiotics which generate B vitamins or butyric acid. In my 'short chain fatty
acid' posting it was noted that butyric acid is good for constipation. But if
you are not constipated you can choose a specific probiotic which produces,
thiamine, riboflavin, or folate. Certain probiotics produce all three
B vitamins. Having an inbuilt bacterial-producing multi B vitamin is an interesting idea. There is an chart listing each probiotic and its associated short chain fatty
acid/B vitamin. I found this article after noting that Park Bear's constipation
is improved by taking thiamine.
Beneficial effects on host energy metabolism of short-chain fatty acids and
vitamins produced by commensal and probiotic bacteria
microbialcellfactories.biom...
s12934-017-0691-z
-----------------------------------
The following article notes the relationship of gram negative colonization
in Parkinson's disease patients mouths with aspiration pneumonia.
The incidence of oral Gram-negative bacteria in patients with Parkinson's
disease
"We found that the oral cavity of 16 (32%) of the patients with Parkinson's
disease was abnormally colonised with Gram-negative bacteria and that
Gram-negative bacteria were more likely to occur in those patients in whom
oromuscular dysfunction was present (88% vs. 21%; p<0.05). Conclusion:
Further work is required to determine the association between oral flora
and the pathogenic organisms found in aspiration pneumonia as well as work
on innovative treatments to reduce oral Gram-negative bacteria in those
patients at particular risk of aspiration pneumonia."
sciencedirect.com/science/a...
So what can be done about gram negative bacteria in your mouth?
Years ago I had poor gums and poor dental insurance. I had receding/bleeding gums and my insurance would not cover going to a periodontist.
Having no option I did an internet search and tried OraMD, the botanical oil
blend of peppermint, spearmint, and almond oil(s) and in short order I could
see the bleeding stop and my gums re-grow. It was the first natural product I
tried and it worked well. I recommended it to a co-worker who had terrible
gums from having a prior drug problem and it too regrew his gums.
"Conclusions: The composite mixture of peppermint, spearmint, and almond
oils has effective antibacterial activity against Gram positive and Gram
negative oral bacteria although appears to be most effective against
Gram negative species."
On the bottle they recommend brushing your teethe with 2-5 drops. I have
never used more than 3 because it is a powerful oil and your mouth will
never taste fresher.
Reductions in fecal short-chain fatty acids (SCFAs) but increased plasma SCFAs were observed in patients with Parkinson's disease
Mucuna pruriens in Parkinson’s
5-HTP in patients not taking Sinemet can worsen symptoms of PD
Researchers Discover Why L-Dopa Stops Working
