Harnessing Probiotics to Deliver Parkinso... - Cure Parkinson's

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Harnessing Probiotics to Deliver Parkinson’s Disease Treatment

jimcaster profile image
35 Replies

Summary: A newly developed probiotic bacteria that can synthesize the dopamine precursor L-DOPA is safe, well-tolerated, and eliminates the side effects associated with L-DOPA use for Parkinson’s

Researchers have engineered probiotic bacteria that can synthesize the dopamine precursor L-DOPA, a powerful mainstay treatment for Parkinson’s disease. Preclinical tests show that the new treatment approach is not only safe and well-tolerated but also eliminates side effects that eventually develop when L-DOPA is taken orally.

neurosciencenews.com/parkin...

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35 Replies
WinnieThePoo profile image
WinnieThePoo

Fabulous. I always knew Parkinson’s was poo

Smittybear7 profile image
Smittybear7

Thanks for sharing. Is this available now?

jimcaster profile image
jimcaster in reply toSmittybear7

Not yet. It appears to work in animal models, but they are in process of initiating FDA approval for clinical testing of this novel gut microbiome therapeutic technology.

Despe profile image
Despe in reply tojimcaster

How long before FDA's approval and when the results of this clinical testing? :)

redhawk1 profile image
redhawk1

Sounds very promising! Thanks for sharing, Jim!

MBAnderson profile image
MBAnderson

Pretty amazing. Good find, Jim.

saraoutwest profile image
saraoutwest

This could be a gamechanger. Fingers crossed

John_morris71 profile image
John_morris71

Thanks for sharing. Hope the FDA fast tracks this. Else this is going to take a few years.

Ccihelka profile image
Ccihelka

I'm very excited to hear this. Thank you!

Jennyjenny2 profile image
Jennyjenny2

Thanks, Jim. 🤞🤞🤞

jeeves19 profile image
jeeves19

Cheers Jim 🙏

akgirlsrock profile image
akgirlsrock

Nice🌺

Zardoz profile image
Zardoz

If this is eventually available, let's hope they don't price gouge like the manufacturers of PS128.

akgirlsrock profile image
akgirlsrock

Will we still have to watch the timing on protein intake?

jimcaster profile image
jimcaster in reply toakgirlsrock

Good question. I don't know the answer.

Annieartist profile image
Annieartist

Fantastic

SusanRenee profile image
SusanRenee

What can we do to get priority on FDA to fast track such things?

Millbrook profile image
Millbrook

Sounds great and promising. Thanks Jim. I firmly believe in probiotics and the saying all disease begins in the gut seems to ring true.

I remember Farooqi posting on the small clinical trial on PS 128 in February 2021 by Benedbiomed and how that led me to the Taiwanese PS 128 which my husband has been taking since June 2021.

It has been life changing- though my husband keeps asking me - are you sure this is helping me? He is tired of the heaps of supplements and capsules he has to swallow. I don’t blame him.

The thing is PD pervades practically every part of the body- from sleep, balance, fatigue, digestion, nocturia, constipation, brain fog etc and throw in atrial fibrillation and bladder CA as well. Hence a plethora of supplements to address the many symptoms.

It is stressful dealing with all this but Hell hath no fury than a woman who has been told I don’t want to take so many supplements after she has spent hours trying to decipher clinical trials and trying to find the best combination. Anyone looking at my supplement cupboard would think I was nuts. But hope springs eternal- like Despe, CC and many others we keep looking for that magical elixir that will make everything right again and more bearable.

So Jim, I look forward to trying the new probiotic though I am presently really happy with PS 128 ( and the coronet duo ) and what it has achieved for us. God is good.

kevowpd profile image
kevowpd in reply toMillbrook

Has your husband been dx with PD, Millbrook?

Millbrook profile image
Millbrook in reply tokevowpd

He has not been diagnosed though a neurologist did say he was slower on one side. My dad had PD and I am seeing a replay of the symptoms.

Shorebird profile image
Shorebird in reply toMillbrook

Hi Millbrook- do you mind if I ask if there were any symptoms in particular that were helped by the PS128 and the coronet duo? I ordered the PS128 - and my husband with PD has taken it for about a month (one capsule in the morning) but I must admit not consistently (my fault- he rakes it when I remember to give it to him). Any advice you have would be greatly appreciated.

Despe profile image
Despe in reply toMillbrook

My thoughts and best wishes are always with you, Millbrook.

Millbrook profile image
Millbrook in reply toDespe

Thank you Despe. 🥰

Zella23 profile image
Zella23

Sounds very promising! Thanks for posting Jim 🙏

Pinca6 profile image
Pinca6

Thank you, Jim!

Millbrook profile image
Millbrook

Hi Shorebird.

My husband takes 2 sachets of PS 128 just before bed. That is the dose used in the clinical trial by Benedbiomed. Some members have got results taking one sachet of 30 billion but others have had no results taking one.

I wrote a post on PS 128 after taking it for 2.5 weeks and the coronet duo for 6 weeks both of which we have continued since May/June 2021.

I am very religious about taking PS 128 and if we forget at night, he takes it the next morning on an empty stomach and again before bed.

Here are the most significant improvements:-

1. Balance normalised

No more stumbling

2. Akinesia - slow movements normalised.

3. Driving- normalised as opposed to snail travel and poor lane discipline

4. More alert

You can also read about the improvements delboy had taking PS 128.

Presently he only uses the coronet once a day.

in reply toMillbrook

Is this where you get it from?

solaceprobiotic.com/?utm_so...

Appears they are out of stock. I thought it was pills only. Sachets are preferable I think

Millbrook profile image
Millbrook in reply to

Hi CC,

I bought it from wellbeingsg.com

If you purchase 10 boxes you get 2 free.

I get the green one with PS 128 +K21- ACTIVE

It is in powder form and one sachet is 30 billion so he takes 2 sachets =60 billion as per clinical trial.

kind2animals profile image
kind2animals

This looks very interesting!

chartist profile image
chartist

Jim,

This sounds similar to how Berberine works through the gut microbiome to produce more levodopa and dopamine in the brain. Berberine in studies has shown the ability to reduce levodopa dosing .

ncbi.nlm.nih.gov/pmc/articl...

Art

Propertytyphoon profile image
Propertytyphoon

Thanks for sharing

ryant123 profile image
ryant123

Hello, Good day.

What about non engineered probiotics? Using them to ferment foods that would raise L-Dopa? There's the Mucuna Pruriens bean.

studyfinds.org/gut-power-st... An article was pretty upbeat about Bacillus Subtilis.

Has anyone used Bacillus Subtilis?

jimcaster profile image
jimcaster in reply toryant123

If you use the search function on this site, you will find several posts regarding Bacillus Subtilis. Good luck!

gaga1958 profile image
gaga1958

interesting, any update on this?

jimcaster profile image
jimcaster in reply togaga1958

I'm not aware of any updates. The pace of progress is sooo frustrating.

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