Summary: A newly developed probiotic bacteria that can synthesize the dopamine precursor L-DOPA is safe, well-tolerated, and eliminates the side effects associated with L-DOPA use for Parkinson’s
Researchers have engineered probiotic bacteria that can synthesize the dopamine precursor L-DOPA, a powerful mainstay treatment for Parkinson’s disease. Preclinical tests show that the new treatment approach is not only safe and well-tolerated but also eliminates side effects that eventually develop when L-DOPA is taken orally.
Not yet. It appears to work in animal models, but they are in process of initiating FDA approval for clinical testing of this novel gut microbiome therapeutic technology.
Sounds great and promising. Thanks Jim. I firmly believe in probiotics and the saying all disease begins in the gut seems to ring true.
I remember Farooqi posting on the small clinical trial on PS 128 in February 2021 by Benedbiomed and how that led me to the Taiwanese PS 128 which my husband has been taking since June 2021.
It has been life changing- though my husband keeps asking me - are you sure this is helping me? He is tired of the heaps of supplements and capsules he has to swallow. I don’t blame him.
The thing is PD pervades practically every part of the body- from sleep, balance, fatigue, digestion, nocturia, constipation, brain fog etc and throw in atrial fibrillation and bladder CA as well. Hence a plethora of supplements to address the many symptoms.
It is stressful dealing with all this but Hell hath no fury than a woman who has been told I don’t want to take so many supplements after she has spent hours trying to decipher clinical trials and trying to find the best combination. Anyone looking at my supplement cupboard would think I was nuts. But hope springs eternal- like Despe, CC and many others we keep looking for that magical elixir that will make everything right again and more bearable.
So Jim, I look forward to trying the new probiotic though I am presently really happy with PS 128 ( and the coronet duo ) and what it has achieved for us. God is good.
Hi Millbrook- do you mind if I ask if there were any symptoms in particular that were helped by the PS128 and the coronet duo? I ordered the PS128 - and my husband with PD has taken it for about a month (one capsule in the morning) but I must admit not consistently (my fault- he rakes it when I remember to give it to him). Any advice you have would be greatly appreciated.
My husband takes 2 sachets of PS 128 just before bed. That is the dose used in the clinical trial by Benedbiomed. Some members have got results taking one sachet of 30 billion but others have had no results taking one.
I wrote a post on PS 128 after taking it for 2.5 weeks and the coronet duo for 6 weeks both of which we have continued since May/June 2021.
I am very religious about taking PS 128 and if we forget at night, he takes it the next morning on an empty stomach and again before bed.
Here are the most significant improvements:-
1. Balance normalised
No more stumbling
2. Akinesia - slow movements normalised.
3. Driving- normalised as opposed to snail travel and poor lane discipline
4. More alert
You can also read about the improvements delboy had taking PS 128.
This sounds similar to how Berberine works through the gut microbiome to produce more levodopa and dopamine in the brain. Berberine in studies has shown the ability to reduce levodopa dosing .
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Macuna Pruriens - people were asking about this herb and this is info of the web - but it is an interesting article. 
Rethinking Parkinson’s Disease: could dopamine reduction therapy have clinical utility. (The article)
L-carnosine
Scientists at NTU Singapore and KAIST uncover a new mechanism that causes Parkinson’s disease
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease
