Side effects of Prednisolone

Hi all,

I've recently had a severe flare of UC and was in hospital for a week on hydrocortisone shots. I was discharged a week ago and I'm now taking Prednisolone but I'm having horrible side effects of shaking and lethargy. Has anyone experienced these side effects as my GP said it isn't normal to feel like this on Prednisolone? I also felt very fatigued on the hydrocortisone too but didn't shake.

Any advice welcome

Jo x

10 Replies

  • hi yes i have had this side affect from prednisolone as i have CD my GP gave me a mild anti depressant which helped . prednisolone is brillant at controlling but not so nice side affects . You may find you will want to eat for England and very restless but it does decrease when you lower the dose .. i hope this helps

  • Hi Tonyputt,

    Thank you for replying - it's reassuring to know that other people have experienced these side effects although they are horrible. My GP didn't have a clue!


  • Your very welcome .

    i was on these steriods for way too long . but an anti depressant will stop the shaking and any mood swings you may have from using the steriod. you are very right the side effects are horrible and they do not taste very nice either unless your lucky to have coated tablets. You should also have calcium tablets as well .

    But they do work very well

  • I ended up with steroid psychosis - not pleasant at all. that was along with the fluid retention, esp knees so walking was really painful, heartburn, palpitations, not sleeping the list goes on. It totally messed up my metabolism too so was unable to lose any weight afterwards - did when had flare up, just to be put back on steroids again. I'm unable to tolerate them now so rely on different meds.

  • Hi,

    I had a bad reaction to prednisolone too. I had uncontrollable shakes and heart palpitations to the point where one night I thought I was having a heart attack and was taken to emergency department. I also had really bad anxiety and mood swings. So I was quickly taken off it and changed to Budesonide. I've found Budesonide is working well for me with no side effects but it's not covered by the pbs so it's about $130-$160 depending on where you go to purchase this medication. I hope you feel better soon!

  • Hi Jo , I was on prednisilone for almost 7 years , this was back 25 years ago when evenn doctors hadn't heard of Behcets. What I discover is is only a plaster in that once you take it off everything comes back again. Also when you restart it you have to take a higher dose each time and it is only hiding the symptoms not helping to eliminate them. No I dont know your situation but I now have on my medical notes...NO steroids or tramadol. There are other and better meds out there such as Colchicine , azathioprine and many more. I suggest you speak with your consultant and find out your options. Hope this helps


  • Sorry I thought I was in the Behçet's disease section so the medicines I mentioned may not be suitable but the prednisilone facts remain the same.


  • Hi Stuart, I used to just drink tap water but have bought mineral water from Liddel now. I'm thirsty all day so I do drink a lot of fluids including decaf tea & coffee. I haven't heard of consuming silica so will need to research this - thank you for bringing up the topic. Regards Jo

  • Hi Stewart, I researched Silica and was impressed by the claims so ordered bamboo silica capsules to try. I'm still on steroids - down to 15mg now and have horrible side effects every time I drop down. I'm still shaking and tired so really hoping this goes away when I eventually stop.

  • I must have sent my message at the same time you did lol! I've been taking the bamboo silica for about 4-5 days now so will wait and see if it improves my bowel movements. I am always thirsty and drink loads, I started buying mineral water (Buxton) as tap water wasn't doing me any good.

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