Sulfasalazine side effects? UC and Enteropathic Arthritis

I've had UC since 1990 well controlled on Olsalazine which is now unavailable hence the move to Sulfasalazine. Enteropathic Arthritis since May 2015, on prednisolone 10mg until 2 September when reduced to 7.5mg, as full dose of 2gm Sulfasalazine finally achieved in August. Since dropping the pred my fatigue is horrendous, also muscle weakness, some headaches, and occasional dizziness. Terrible "brain fog". I work 16 hours a week over 3 alternate days and seem to spend my days off recovering.

I know that fatigue is part of the arthritis but could it be the Sulfasalazine causing it? I have always had such high energy and been very active with strenuous dog walking, riding and yoga part of my daily routine. I now struggle to walk for only 15/20 minutes and hills are impossible, my legs just won't do it.

I see the rheumatologist in a weeks time so if anyone has experienced something similar I'd love to hear from you.

Thank you

2 Replies

  • I have been taking Sulfasalazine for almost a year, and have only slight changes in my muscle strength. In my case, at 85, I attribute my diminished capacity to my age. At this point in my life, I'm just glad my mind is working well.

  • It's good to hear it seems to be working well for you Jaykay. As I'm 58 I don't think I can blame my age, but it will be interesting to hear what the rheumatologist thinks.

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