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Combination therapy
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My path to combination therapy
I was diagnosed with hypothyroidism about 25 years ago, in my mid-thirties. For almost 20 years, I took only Levothyroxine. I realise now that I was probably depressed for the whole period. Back in 2016, I decided to quit drinking alcohol. I wasn't an alcoholic, but I was drinking every day, and sometimes
I was diagnosed with hypothyroidism about 25 years ago, in my mid-thirties. For almost 20 years, I took only Levothyroxine. I realise now that I was probably depressed for the whole period. Back in 2016, I decided to quit drinking alcohol. I wasn't an alcoholic, but I was drinking every day, and sometimes
Morphiouso
in
Thyroid UK
2 months ago
Suppressed TSH on combined therapy
Is there data/medical papers I can give my doctor as to why T3 is suppressed on
combination
therapy
? I have tried looking at the Nice guidelines but they all seem against using combination therapy.Thanks Sue
Is there data/medical papers I can give my doctor as to why T3 is suppressed on
combination
therapy
? I have tried looking at the Nice guidelines but they all seem against using combination therapy.Thanks Sue
redhead41
in
Thyroid UK
3 months ago
Blood results
Should T4 still be within range when on
combination
therapy
? Does it sound right that I should be on the same dose of Levo now during
combination
therapy
as I was before adding in T3? No meds taken before early blood draw.
Should T4 still be within range when on
combination
therapy
? Does it sound right that I should be on the same dose of Levo now during
combination
therapy
as I was before adding in T3? No meds taken before early blood draw.
Turquoisenona
in
Thyroid UK
13 days ago
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Treatment Preferences in Patients with Hypothyroidism: an Analysis of Eleven Randomized Controlled Trials
[/i] [i]L-T4, L-T3, DTE, Hypothyroidism, Patient preference,
Combination
therapy
[/i] Behind a paywall - as so often: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae651/7759898
[/i] [i]L-T4, L-T3, DTE, Hypothyroidism, Patient preference,
Combination
therapy
[/i] Behind a paywall - as so often: https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae651/7759898
helvella
Thyroid UK
in
Thyroid UK
4 hours ago
combination therapy for ADHD
I read about
combination
therapy
and I'm going to ask my doctor about it tomorrow.
I read about
combination
therapy
and I'm going to ask my doctor about it tomorrow.
starsallover
in
CHADD's Adult ADHD Support
5 months ago
Side effects on combination therapy : thyroxine and T3
I have been on
combination
therapy
for about 7 weeks. I have noticed I am quite breathless and this looks like it can be related but unusual. Does this sound familiar to anyone?
I have been on
combination
therapy
for about 7 weeks. I have noticed I am quite breathless and this looks like it can be related but unusual. Does this sound familiar to anyone?
TheaW
in
Thyroid UK
4 months ago
Subcutaneous combination therapy improves ‘good on’ time in Parkinson’s
https://www.healio.com/news/neurology/20240709/subcutaneous-
combination
-
therapy
-improves-good-on-time-in-parkinsons
https://www.healio.com/news/neurology/20240709/subcutaneous-
combination
-
therapy
-improves-good-on-time-in-parkinsons
Farooqji
in
Cure Parkinson's
2 months ago
B.A.T and Provenge trial.
I will be starting a
combination
therapy
trial through Yale using B.A.T. And Provenge. This is the first time I’ve heard of such a combo. There are only 6 of us in this trial. Is there anyone else on this trial or have any experience with using both treatments?
I will be starting a
combination
therapy
trial through Yale using B.A.T. And Provenge. This is the first time I’ve heard of such a combo. There are only 6 of us in this trial. Is there anyone else on this trial or have any experience with using both treatments?
No_stone_unturned
in
Advanced Prostate Cancer
4 months ago
EMBARK Trial: Combination-therapy is better.
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron
combination
therapy
.
This chart compares the risk of developing metastasis from prostate cancer, after 5 years from curative treatment, between three different arms of the EMBARK study (published in 2023): (1) Lupron monotherapy; (2) Enzalutamide monotherapy; and (3) Enzalutamide + Lupron
combination
therapy
.
janebob99
in
Prostate Cancer Network
5 months ago
NDT vs T4 T3 combination therapy
Please share your experience NDT vs
combination
therapy
. Currently I am on combo but still have symptoms (I have no thyroid). I am doing better on combo than on T4 only. I want to try NDT and see if it will make me feel better.
Please share your experience NDT vs
combination
therapy
. Currently I am on combo but still have symptoms (I have no thyroid). I am doing better on combo than on T4 only. I want to try NDT and see if it will make me feel better.
Alex_N
in
Thyroid UK
5 months ago
T3 T4 Dosing
Just seen endo (well endo's registrar actually) and started on T3/T4
combination
therapy
.
Just seen endo (well endo's registrar actually) and started on T3/T4
combination
therapy
.
JoanC645
in
Thyroid UK
25 days ago
Debate on T3 between Prof Bianco & Prof Pearce
Prof Bianco was 'for' the use of T3 in
combination
therapy
, and Prof Pearce was 'against' it. We know that these are their personal stances anyway, even when not in a formal debate setting. Prof Bianco 'won' the debate, though I can't recall the actual voting numbers.
Prof Bianco was 'for' the use of T3 in
combination
therapy
, and Prof Pearce was 'against' it. We know that these are their personal stances anyway, even when not in a formal debate setting. Prof Bianco 'won' the debate, though I can't recall the actual voting numbers.
TaraJR
in
Thyroid UK
3 months ago
T4 and T3 split dosing
For those who are on T4 / T3
combination
therapy
, please can you share your regime and also what were your symptoms before and after splitting ?Thank you in advance.
For those who are on T4 / T3
combination
therapy
, please can you share your regime and also what were your symptoms before and after splitting ?Thank you in advance.
Lavender-Blue
in
Thyroid UK
6 months ago
Digoxin with Bisoprol
'[i]
therapy
of beta-blockers and digoxin is associated with increased risk of major adverse cardiovascular events and all-cause mortality in patients with atrial fibrillation: a report from the GLORIA–AF registry[/i]'. Published on 23 May 2024.
'[i]
therapy
of beta-blockers and digoxin is associated with increased risk of major adverse cardiovascular events and all-cause mortality in patients with atrial fibrillation: a report from the GLORIA–AF registry[/i]'. Published on 23 May 2024.
priya_uk
in
Atrial Fibrillation Support
8 days ago
Abiraterone/prednisone plus olaparib extends time to progression in BRCA/ATM mutated prostate cancer.
“Our data showed that the
combination
therapy
resulted in more than two-fold increase in the median time to disease progression compared to single-agents or sequentially following progression,” Hussain said.
“Our data showed that the
combination
therapy
resulted in more than two-fold increase in the median time to disease progression compared to single-agents or sequentially following progression,” Hussain said.
Maxone73
in
Advanced Prostate Cancer
11 days ago
Research paper about T3/T4combination treatment. What happened there?
Only 11% of
combination
therapy
participants preferred the
combination
therapy
, whereas 56% of
combination
therapy
patients and 60% of placebo patients considered the
combination
therapy
to be more complicated than monotherapy.
Only 11% of
combination
therapy
participants preferred the
combination
therapy
, whereas 56% of
combination
therapy
patients and 60% of placebo patients considered the
combination
therapy
to be more complicated than monotherapy.
buddy99
in
Thyroid UK
8 months ago
Update in sustained release T3 and new paper
The recent review of treatment for hypothyroidism recommended further research to look at
combination
therapy
. A group in Iran have done the following trial looking at sustained release combination T4/T3.
The recent review of treatment for hypothyroidism recommended further research to look at
combination
therapy
. A group in Iran have done the following trial looking at sustained release combination T4/T3.
Mollyfan
in
Thyroid UK
6 months ago
Abiraterone + Olaparib: ASCO GU 2024 Highlights: BRCAAway Trial
"Highlighting the trial's results, he notes the
combination
therapy
significantly extended median radiographic progression-free survival to 39 months, far surpassing the outcomes with either treatment alone. " 39 months progression free is not bad at all...
"Highlighting the trial's results, he notes the
combination
therapy
significantly extended median radiographic progression-free survival to 39 months, far surpassing the outcomes with either treatment alone. " 39 months progression free is not bad at all...
Maxone73
in
Advanced Prostate Cancer
7 months ago
Low cortisol
My 40 year old daughter has Hashimoto's on T4 /T3
combination
therapy
for 6 years. Optimal levels plus optimal B12, folate, vit d and ferritin.Dutch test has shown very low cortisol levels throughout the day.
My 40 year old daughter has Hashimoto's on T4 /T3
combination
therapy
for 6 years. Optimal levels plus optimal B12, folate, vit d and ferritin.Dutch test has shown very low cortisol levels throughout the day.
redhead41
in
Thyroid UK
7 months ago
Got in a mess over reduction of T4
I asked for t4/t3
combination
therapy
and he said come back to see me in a month for consideration but request full bloods from GP before this.
I asked for t4/t3
combination
therapy
and he said come back to see me in a month for consideration but request full bloods from GP before this.
Sailing14
in
Thyroid UK
8 days ago
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