low dose aspirin

[Silvafoxe]

My cardiologist wants me to take a baby aspirin daily but I’m on brukinsa. I wonder if there will be issues. I will call oncology before I start taking it. Wonderful if anyone had experience with these two.

[AussieNeil Partner Administrator]

Good move. BKT inhibitors unfortunately have an off-target effect on the kinase in platelets, which reduces their clotting efficiency.

[Silvafoxe in reply to AussieNeil]

Thank you AussieNeill

[julius_the_cat in reply to AussieNeil]

Here is a related review from last year: jscai.org/article/S2772-930...

The relative risk/benefit will depend on the indication you have for aspirin. It's possible the BTKi may provide sufficient anti-platelet effect (reduced clotting) so that aspirin may not be required.

Unfortunately, insufficient data at present so it's a judgment call. A cardio-oncologist would be helpful if available as many cardiologists and surgeons will have limited BTKi experience/knowledge.

[Panz]

No I don’t have any experience with that comb but I do with Calquence and Baby Aspirin. I have been on Calquence for 3 years and 18 months ago I had a TAVR (Aorta Valve Replacement) and both the cardiac surgeon and my cardiologist have me on a Baby Aspirin and there have been no issues. My platelets do run 70-105. I really think people are all so different it just depends on the individual.

I hope you are able to get this checked out. If it were me I would go straight to the pharmacy where you get your Burkinsa. I feel they know more the the doctors on drug interactions…..just a thought!

All the very best to you!!!

Panz 💕😊🤞🙏

[Silvafoxe in reply to Panz]

Thank you for your suggestion.

[Skyshark]

Avoid alcohol, it can increase risk of bleeding.

drugs.com/interactions-chec...

[akirsch973]

Hi

I have been taking Brukinsa since July 19 and an 81 mg aspirin tablet daily since June and have had no problems. I had mitral valve repair surgery last December and was initially on warfarin. I was switched to Eliquis in January for a few months and then to baby aspirin. Before I started taking Brukinsa I reviewed each medication I was taking with my oncologist’s pharmacist and my oncologist and got the green light. Good luck!

[gardener58]

I've been on both since last September with no issues.

[SERVrider]

Like a prat, I had surgery to remove a BCC and do a skin-flap and forgot to stop Acalabrutinib beforehand. Wound wouldn't stop bleeding. Then I remembered to stop taking the BTKi. The bleeding has stopped and I'm getting it redressed tomorrow. The surgery may be minor but once you make a hole in the bag that keeps the insides in and the outsides out, it matters not how "minor" the surgery is; it's just going to bleed!

[CLLinPA]

I had an aortic value replacement and I take a 325 mg Aspirin and Acalabrutinib daily. My cardiologist and oncologist are fine with that. It’s been 3.5 years on Acala, aspirin 9 yeats

[Agiledog]

While both aspirin and BTKIs impact platelet function and clotting, they do so through different pathways—aspirin through the inhibition of thromboxane A2 production and BTKIs through the inhibition of signaling pathways involved in platelet activation.

Not sure this matters, as I suppose anti -clotting is anti-clotting. But following my heart cath, my cardiologist declined an anti-clotting med since I was on acalabtutinb. Seems the picture remains cloudy as to pro/con.

Bud

[michaeledward]

I take ibrutinib and when I took daily low dose aspirin I had frequent nose bleeds. However, I don’t know if the effect would be the same with brukinsa.

[TruthJunkie]

Gosh, I am rather surprised at the number of patients taking BTKi meds and taking aspirin. I have been on Zanubrutinib for 17 months. In June, I had extreme epistaxis (a monumental nose bleed). I had never had a nose bleed in my life. Had to go to ER, and bleeding continued (despite “Rhino Rockets” being pushed into the one side of the nose, to try to stop bleeding. Painful, and ultimately unsuccessful. I had an immense amount of blood clotting in my throat, and going into stomach. At some point, all of the blood clots in stomach came flying up out of me. It was brutal, and lasted for 4.5 hours, before ENT arrived. He told me that he would have to anesthetize me and cauterize the posterior nasal cavity. Adverse effects could include: “brain damage, blindness and/or continued hemorrhage.” I hope that no one else ever has to experience this. It took a lot out of me. Then, they tried to put me on the hospital floor, with no air-conditioning or even a fan. It was easily 95F at that point. I called my husband and told him to please come get me! He did, and I was able to rest in air-conditioned bedroom at home.