Will spleen shrink after Rituximab treatment?

[Redkatt]

Just wondering if spleen will shrink after having 4 Rituximab treatments? Is this usually what happens?

[lankisterguy Volunteer]

Hi Redkatt,

Mine did, but it was slower than using a BTK or BCL2 inhibitor.

But one of your past postings indicated you have SMZL not CLL , so YRMV (your results may vary). macmillan.org.uk/cancer-inf...

healthunlocked.com/cllsuppo...

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For CLL patient results please see the box on this page labeled: " Related Posts

*Treatment after enlarged spleen and low platelets?

*Partial treatment to shrink nodes

*Treatment with Rituximab

*Spleen symptoms during treatment.

*Very enlarged spleen - reason for treatment?

And to your other posting:

*How enlarged is an enlarged spleen?

*Anyone had/have an enlarged spleen that ended up not being connected to CLL?

*Stage 0 W&W: Questions for CLL Specialist?

*Question for those with enlarged spleens…

*Watch & Wait - now enlarged spleen

Len

[Redkatt in reply to lankisterguy]

At this stage have both CLL and MZL

[mantana]

My spleen was 20+ cm, with some blood parameters low when I had my rituximab treatment - 4 weekly infusions - 2 years ago (and my diagnosis changed from CLL to SMZL a bit before that).

My spleen shrunk to around 11 cm, though it took a few months to do so.

My blood parameters returned to normal, except platelets, which are a bit below the norm.

So far, everything's stable!

[Redkatt in reply to mantana]

Thanks for your reply. What tests were done to determine you had SMZL rather than CLL?

[mantana in reply to Redkatt]

Well, they scratched their heads for long, because although I had an initial CLL diagnosis (made in a different country), they knew it doesn't really look like CLL and they struggled to name the disease correctly.

I think they agreed its SMZL once my spleen got big; I had no enlarged nodes, no mutations, no deletions, but white cell clones, worsening platelets and hemoglobin.

[W00dfin]

Mine shrank after one treatment.

[Redkatt in reply to W00dfin]

How good is that

[W00dfin]

My stomach had been so compressed by my spleen that I had no appetite. BTW I had the 3 part FCR treatment