My one month blood results.

[Seaway789]

I have been just a little worried about falling out of remission. But today I feel a bit better. Seeing my platelets rising. Hoping the Best to all. 🙏

[SofiaDeo]

Congrats, I wish my labs looked like this lol!

[LeoPa]

My WBC is lower (probably my lymphocyte absolute count too) but I'm not in remission. So I'm confused. How do they define remission?

[Baz209 in reply to LeoPa]

I believe remission is a lymphocyte count of below 5. The normal range is 1,000 to 4,800. No more CLL cells seen.

[LeoPa in reply to Baz209]

Isn't remission when there is no detectable sign of disease? Like mrd or umrd. When I got my diagnosis my absolute lymphocyte count was below 5000. They call it high count MBL but it is de facto an early stage of CLL.

[Baz209 in reply to LeoPa]

One of my oncologist wasn't too concerned about MBL when I had it lol, me I was flipping. The other oncologist was focused on the lymphocytes count as in layman's terms that's where CLL is and I asked I him about remission and he said normal count no more CLL seen. And if you think about it treatment is about destroying the CLL cells for a normal count. I'm on watch and wait.

[Skyshark in reply to LeoPa]

uMRD is not a criteria for remission, it's a clinical trial endpoint (primary or secondary). Everything listed under CR of Table 4 has to be met. Most are blood tests but node sizes and liver/spleen size are by CT scan and Marrow requires a bone marrow biopsy.

There are also uCR and CRi. uCR is unconfirmed CR without a BMB. CRi is CR with incomplete count recovery, the platelet and haemoglobin can be outside of normal range.

ashpublications.org/blood/a...

I was at uCR by cycle 7 of V+O. Had CT scan and BMB after cycle 12. Hope the CT still shows lymph nodes are still behaving. Ten day count down until I get BMB results.

IwCLL remission criteria

[LeoPa in reply to Skyshark]

Note the bone marrow parameter for complete remission. If there are none in the bone marrow then most likely none are anywhere else either.

Screenshot

[Skyshark in reply to LeoPa]

But it's by microscopic examination, not a count by cytometry of n in 10,000, 100,000 etc.

[LeoPa in reply to Skyshark]

Ah so, thanks.