Hi Everyone!
I have been on Calquence for just about a month and had my first labs yesterday. Neuts were normal. Platelets were steady at 120. My absolute WBC was 106,000 from 43,000, but that was to be expected. However, my hemoglobin was 10.3 from 11.2. I know it's just a slight decrease, but has anyone else run into this, and if so, did it return to normal?
Thank you!
This is entirely expected and is why it is important to start treatment within an optimum treatment window. All CLL treatment drugs are capable of suppressing your bone marrow, so when your bone marrow is already CLL infiltrated, it's not unusual to see a temporary further drop in haemoglobin, platelets and or neutrophils while Calquence slowly begins clearing out your bone marrow. You can anticipate seeing your haemoglobin begin to improve in the near future.
Neil
Thank you, Neil!
I experience the same been on calquence for 9 months and my hemoglobin did the same as well as my other levels but wbc was 178.000 now down to 22,000. Stay positive much love and blessings
I was on a different treatment but my Hb was dipping and going up and down for the first two months...it has been fine since then.
Hi, I have been on Acalabrutinib, Aciclovir and Dapsone (was Co-trimoxazole) since January 2022 (diagnosed SLL / CLL December 2020), usual headaches at the start but all good after 3L water and coffee, now 2L a day. I had slight Lymphadenopathy in September last year that resolved itself within a month amongst other changes but they were at the start as expected.
I also have high risk variants, LEU and ATM genes.
Current situation after 18 Months the latest report from my Hematologist to my doctor was:
There was no evidence of leukemia. I advised Mr Brown to continue on Acalabrutinib 100mg twice daily and prophylactic Aciclovir 400mg twice daily and Dapsone 100mg daily
Calquence is working well for me and hopefully should with you as well, there are always a few changes in all the blood results. I have been lucky with no actual symptoms apart from very large Lymph nodes in my Neck and Groin which started the visit to the doctor in August 2020.
I also keep fit and the gym and have been on a CLL HIT programme with Surrey University and try and eat a healthy diet which all contributes to a good balance.
I hope all goes well for you, I manage to get on with things and continue to work but I am 63 so a few years to go before retirement
safe journey
I note you are on the HIT research programme at Surrey University, I live in Guildford and use the Surrey Sports Park (part of the University) for my fitness classes. I wonder whether I would be of any use to the HIT study. Could you give me a contact in the study to apprach, please?
Hi albie58 , so far you are doing better than i did on the calquence but i would still keep an eye on the hemoglobin especially ... when i started taking calquence my platelets were 100... my hemoglobin was 8.1 .. lymphocytes 16,000 . . my G.P. checked my iron and it was low so i had a couple of iron infusions the second month after i started calquence and with in a couple of months after that my hemoglobin was up to 11.6 ... but my platelets kept steadily dropping . after taking calquence for 9 months i had to stop taking it .. my hemoglobin was 6.4 my lymphocytes were 2.1 ... my platelets were 19 . i started gazyva -plus blood transfusions etc. ... my neutrophils went down to .15 ... so i had to have a shot of neulasta . which worked very rapidly with in 4 days my neutrophils were 11 an increase of 73 times the starting amount . so be vigilant the calquence worked TO WELL for me ....causing cytopenia ---- the venetoclax is working much better with less side effects ... blessings , keep looking up .. james
Imbruvica and low Hemoglobin 
Just started Calquence
Coming Off Calquence (
Calquence not really working
